Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm

Recurrence and Survival After Resection of Small Intraductal Papillary Mucinous Neoplasm-associated Carcinomas (≤20-mm Invasive Component)

(2016) Jordan M. Winter et al.   ANNALS OF SURGERY

Validation of the 2012 International Consensus Guidelines Using Computed Tomography and Magnetic Resonance Imaging

(2016) Nieun Seo et al.   ANNALS OF SURGERY

Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract

(2016) Volkan Adsay et al.   ANNALS OF SURGERY

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS

(2016) Wanglong Qiu et al.   GASTROENTEROLOGY

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

(2016) Changqing Ma et al.   HUMAN PATHOLOGY

Prediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival

(2016) Chen Yuan et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer

(2016) Chen Yuan et al.   JNCI-Journal of the National Cancer Institute

The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes

(2016) Olca Basturk et al.   MODERN PATHOLOGY

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Distinction of Invasive Carcinoma Derived From Intraductal Papillary Mucinous Neoplasms From Concomitant Ductal Adenocarcinoma of the Pancreas Using Molecular Biomarkers

(2016) Koji Tamura et al.   PANCREAS

Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas

(2016) Suguru Matsuzaka et al.   PANCREAS

Assessment of Malignant Potential in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Comparison between Multidetector CT and MR Imaging with MR Cholangiopancreatography

(2016) Hyo-Jin Kang et al.   RADIOLOGY

Epac Activation Regulates Human Mesenchymal Stem Cells Migration and Adhesion

(2016) Jiao-Le Yu et al.   STEM CELLS

Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas

(2016) Olca Basturk et al.   VIRCHOWS ARCHIV

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer

(2016) Chen Yuan et al.   JNCI-Journal of the National Cancer Institute

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Presence of pancreatic intraepithelial neoplasia-3 in a background of chronic pancreatitis in pancreatic cancer patients

(2015) In Kyeom Hwang et al.   CANCER SCIENCE

Molecular Characterization and Pathogenesis of Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2015) Julia Benzel et al.   EUROPEAN SURGICAL RESEARCH

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model

(2015) Patricia Alamo et al.   FASEB JOURNAL

Management of Pancreatic Cysts: The Evidence Is Not Here Yet

(2015) Carlos Fernández-del Castillo et al.   GASTROENTEROLOGY

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

(2015) Simeon Springer et al.   GASTROENTEROLOGY

American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

(2015) Santhi Swaroop Vege et al.   GASTROENTEROLOGY

Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway

(2015) Eui-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accuracy of 18F-FDG PET/CT, Multidetector CT, and MR Imaging in the Diagnosis of Pancreatic Cysts: A Prospective Single-Center Study

(2015) S. Kauhanen et al.   JOURNAL OF NUCLEAR MEDICINE

Oncocytic-Type Intraductal Papillary Mucinous Neoplasms: A Unique Malignant Pancreatic Tumor with Good Long-Term Prognosis

(2015) Giovanni Marchegiani et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma

(2015) Marcus C. Tan et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

GNAS R201H and Kras G12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm

(2015) K Taki et al.   ONCOGENE

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

Brg-1 targeting of novel miR550a-5p/RNF43/Wnt signaling axis regulates colorectal cancer metastasis

(2015) G Wang et al.   ONCOGENE

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Molecular Biomarkers for Progression of Intraductal Papillary Mucinous Neoplasm of the Pancreas

(2015) Yuko Kuboki et al.   PANCREAS

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

(2015) Mark Sausen et al.   Nature Communications

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as “Incipient IPMNs”

(2014) Hanno Matthaei et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Clinical Implication of Morphological Subtypes in Management of Intraductal Papillary Mucinous Neoplasm

(2014) Suguru Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

Peritoneal seeding in intraductal papillary mucinous neoplasm of the pancreas patients who underwent endoscopic ultrasound-guided fine-needle aspiration: The PIPE Study

(2014) Won Yoon et al.   ENDOSCOPY

Through-the-skin ERCP and endoscopic ultrasound-guided cystogastrostomy in a patient with a Roux-en-Y gastric bypass

(2014) Joshua Max et al.   ENDOSCOPY

Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor

(2014) Yasunori Oda et al.   HISTOPATHOLOGY

Invasive carcinoma derived from “flat type” branch duct intraductal papillary mucinous neoplasms of the pancreas: impact of classification according to the height of mural nodule on endoscopic ultrasonography

(2014) Shinsuke Koshita et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas

(2014) Hitomi Sakamoto et al.   MODERN PATHOLOGY

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Absence of Pancreatic Intraepithelial Neoplasia Predicts Poor Survival After Resection of Pancreatic Cancer

(2014) Benjamin G. Hassid et al.   PANCREAS

Deep Sequencing of Cancer-Related Genes Revealed GNAS Mutations to Be Associated with Intraductal Papillary Mucinous Neoplasms and Its Main Pancreatic Duct Dilation

(2014) Shinichi Takano et al.   PLoS One

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Intraductal Papillary Mucinous Neoplasms of the Pancreas With Distinct Pancreatic Ductal Adenocarcinomas Are Frequently of Gastric Subtype

(2013) Noboru Ideno et al.   ANNALS OF SURGERY

Imaging Features to Distinguish Malignant and Benign Branch-Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2013) Kyung Won Kim et al.   ANNALS OF SURGERY

Incidentally Discovered Pancreatic Intraepithelial Neoplasia: What Is Its Clinical Significance?

(2013) Ioannis T. Konstantinidis et al.   ANNALS OF SURGICAL ONCOLOGY

Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

(2013) Marco Dal Molin et al.   ANNALS OF SURGICAL ONCOLOGY

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC

(2013) Alex Burdyga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel Serum Metabolomics-Based Diagnostic Approach to Pancreatic Cancer

(2013) T. Kobayashi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

European experts consensus statement on cystic tumours of the pancreas

(2013) Marco Del Chiaro et al.   DIGESTIVE AND LIVER DISEASE

Role of endoscopic ultrasonography in pancreatic cystic neoplasms: Where do we stand and where will we go?

(2013) Yousuke Nakai et al.   Digestive Endoscopy

Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

(2013) Stephen J. Murphy et al.   GASTROENTEROLOGY

Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas

(2013) Manish K. Gala et al.   GASTROENTEROLOGY

mAb Das-1 is specific for high-risk and malignant intraductal papillary mucinous neoplasm (IPMN)

(2013) Koushik K Das et al.   GUT

Hepatobiliary and Pancreatic Neoplasms in Patients With McCune-Albright Syndrome

(2013) Sébastien Gaujoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

(2013) Masao Tanaka et al.   PANCREATOLOGY

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dysplasia at the surgical margin is associated with recurrence after resection of non‐invasive intraductal papillary mucinous neoplasms

(2013) Timothy L. Frankel et al.   HPB

Searching for Indicators of Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasms: The Value of 18FDG–PET Confirmed

(2012) Gian Luca Baiocchi et al.   ANNALS OF SURGICAL ONCOLOGY

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Multiple small “imaging” branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?

(2012) D. K. Bartsch et al.   Familial Cancer

What We Have Learned About Pancreatic Cancer From Mouse Models

(2012) Pedro A. Pérez–Mancera et al.   GASTROENTEROLOGY

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

(2012) Mitsuro Kanda et al.   GASTROENTEROLOGY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

(2012) A. H. Shain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invasive Carcinoma Arising in Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2011) Adam C. Yopp et al.   ANNALS OF SURGERY

Clinicopathological Characteristics and Molecular Analyses of Multifocal Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2011) Hanno Matthaei et al.   ANNALS OF SURGERY

Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic Cancer

(2011) Hanno Matthaei et al.   ANNALS OF SURGICAL ONCOLOGY

Cyst Fluid Interleukin-1β (IL1β) Levels Predict the Risk of Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2011) Ajay V. Maker et al.   CLINICAL CANCER RESEARCH

The Clinical Relevance of the Increasing Incidence of Intraductal Papillary Mucinous Neoplasm

(2011) David A. Klibansky et al.   Clinical Gastroenterology and Hepatology

Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas

(2011) Isabelle Houbracken et al.   GASTROENTEROLOGY

Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes

(2011) M. Mino-Kenudson et al.   GUT

Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas

(2011) Marco Dal Molin et al.   HUMAN PATHOLOGY

GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation

(2011) Jean Charles Nault et al.   JOURNAL OF HEPATOLOGY

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues

(2011) Michaela Aichler et al.   JOURNAL OF PATHOLOGY

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Cystic precursors to invasive pancreatic cancer

(2011) Hanno Matthaei et al.   Nature Reviews Gastroenterology & Hepatology

Localization of the Most Severely Dysplastic/Invasive Lesions and Mucin Phenotypes in Intraductal Papillary Mucinous Neoplasm of the Pancreas

(2011) Hidenori Karasaki et al.   PANCREAS

Natural History of Branch Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2011) Hiroyuki Maguchi et al.   PANCREAS

Pancreatic Ductal Adenocarcinoma Derived From IPMN and Pancreatic Ductal Adenocarcinoma Concomitant With IPMN

(2011) Koji Yamaguchi et al.   PANCREAS

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

(2011) L. S. Jacob et al.   Science Signaling

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

Primary pancreatic cystic neoplasms revisited: Part II. Mucinous cystic neoplasms

(2011) George H. Sakorafas et al.   SURGICAL ONCOLOGY-OXFORD

Imaging IPMN: Take home messages and news

(2011) M.P. Vullierme et al.   Clinics and Research in Hepatology and Gastroenterology

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

(2011) Toru Furukawa et al.   Scientific Reports

Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer

(2010) Jun Sakamoto et al.   Cancer Epidemiology

Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2010) Carlos Fernández–del Castillo et al.   GASTROENTEROLOGY

Size of mural nodule as an indicator of surgery for branch duct intraductal papillary mucinous neoplasm of the pancreas during follow-up

(2010) Hiroyuki Uehara et al.   JOURNAL OF GASTROENTEROLOGY

In vivo and in vitro propagation of intraductal papillary mucinous neoplasms

(2010) Hirohiko Kamiyama et al.   LABORATORY INVESTIGATION

GNAS imprinting and pituitary tumors

(2010) G. Mantovani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Novel Xenograft and Cell Line Derived From an Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Give New Insights Into Molecular Mechanisms

(2010) Stefan Fritz et al.   PANCREAS

Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma

(2010) Kenji Yamao et al.   PANCREAS

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Serum Fatty Acid Synthase as a Marker of Pancreatic Neoplasia

(2009) K. Walter et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients

(2009) C. Shi et al.   CLINICAL CANCER RESEARCH

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

(2009) David F. Vincent et al.   PLoS Genetics

Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results

(2007) S Tanno et al.   GUT