Diiron monooxygenases in natural product biosynthesis

Convergent Theoretical Prediction of Reactive Oxidant Structures in Diiron Arylamine Oxygenases AurF and CmlI: Peroxo or Hydroperoxo?

(2017) Chao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF

(2017) Kiyoung Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

(2017) Andrew J. Jasniewski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

(2016) Andrew J. Jasniewski et al.   BIOCHEMISTRY

A growing family of O2 activating dinuclear iron enzymes with key catalytic diiron(III)-peroxo intermediates: Biological systems and chemical models

(2016) Alexandre Trehoux et al.   COORDINATION CHEMISTRY REVIEWS

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

(2016) Cory J. Knoot et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structure/function correlations over binuclear non-heme iron active sites

(2016) Edward I. Solomon et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

(2016) Anna J. Komor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expression and characterization of an N-oxygenase from Rhodococcus jostii RHAI

(2015) Karl J. Indest et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway

(2015) Thomas M. Makris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the key species in the enzymatic oxidation of methane to methanol

(2015) Rahul Banerjee et al.   NATURE

Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination

(2015) Zhenggang Han et al.   STRUCTURE

Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena

(2014) Liwei Liu et al.   ACS Chemical Biology

A two-electron-shell game: intermediates of the extradiol-cleaving catechol dioxygenases

(2014) Andrew J. Fielding et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structure of a Dinuclear Iron Cluster-Containing β-Hydroxylase Active in Antibiotic Biosynthesis

(2013) Thomas M. Makris et al.   BIOCHEMISTRY

Intermediate P* from Soluble Methane Monooxygenase Contains a Diferrous Cluster

(2013) Rahul Banerjee et al.   BIOCHEMISTRY

Sc3+-Triggered Oxoiron(IV) Formation from O2 and its Non-Heme Iron(II) Precursor via a Sc3+–Peroxo–Fe3+ Intermediate

(2013) Feifei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Annotation of the Modular Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in the Genome of Streptomyces tsukubaensis NRRL18488

(2012) Marko Blažič et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and Spectroscopic Properties of the Peroxodiferric Intermediate of Ricinus communis Soluble Δ9 Desaturase

(2012) Martin Srnec et al.   INORGANIC CHEMISTRY

Protonation of a Peroxodiiron(III) Complex and Conversion to a Diiron(III/IV) Intermediate: Implications for Proton-Assisted O–O Bond Cleavage in Nonheme Diiron Enzymes

(2012) Matthew A. Cranswick et al.   INORGANIC CHEMISTRY

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

CmlI is an N-oxygenase in the biosynthesis of chloramphenicol

(2012) Haige Lu et al.   TETRAHEDRON

Dioxygen Activation in Soluble Methane Monooxygenase

(2011) Christine E. Tinberg et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of a non-ribosomal peptide synthetase-associated diiron arylamine N-oxygenase from Pseudomonas syringae pv. phaseolicola

(2011) Erin Platter et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification and Characterization of the Lysobactin Biosynthetic Gene Cluster Reveals Mechanistic Insights into an Unusual Termination Module Architecture

(2011) Jie Hou et al.   CHEMISTRY & BIOLOGY

The Nonribosomal Peptide Synthetase Enzyme DdaD TethersNβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis

(2011) Marie A. Hollenhorst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active-Site Structure of a β-Hydroxylase in Antibiotic Biosynthesis

(2011) Van V. Vu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF

(2010) Alexander Fries et al.   CHEMICAL COMMUNICATIONS

Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus

(2010) N. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

(2010) T. M. Makris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b

(2010) Nates An Elango et al.   PROTEIN SCIENCE

Crystallographic and Catalytic Studies of the Peroxide-Shunt Reaction in a Diiron Hydroxylase

(2009) Lucas J. Bailey et al.   BIOCHEMISTRY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Physiological traits of the symbiotic bacterium Teredinibacter turnerae isolated from the mangrove shipworm Neoteredo reynei

(2009) Amaro E. Trindade-Silva et al.   GENETICS AND MOLECULAR BIOLOGY

Characterization of Two Distinct Adducts in the Reaction of a Nonheme Diiron(II) Complex with O2

(2009) Jonathan R. Frisch et al.   INORGANIC CHEMISTRY

A Long-Lived, Substrate-Hydroxylating Peroxodiiron(III/III) Intermediate in the Amine Oxygenase, AurF, fromStreptomyces thioluteus

(2009) Victoria Korneeva Korboukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center

(2009) V. V. Vu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

myo-Inositol oxygenase: a radical new pathway for O2and C–H activation at a nonheme diiron cluster

(2008) J. Martin Bollinger et al.   DALTON TRANSACTIONS

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

(2008) Y. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA