Article
Plant Sciences
Carlos Eduardo Zavala-Gomez, Eloy Rodriguez-deLeon, Mamadou Moustapha Bah, Ana Angelica Feregrino-Perez, Juan Campos-Guillen, Aldo Amaro-Reyes, Jose Alberto Rodriguez-Morales, Juan Fernando Garcia-Trejo, Antonio Flores-Macias, Rodolfo Figueroa-Brito, Miguel Angel Ramos-Lopez
Summary: The study aimed to evaluate the concentration of ricinine in the bagasse of castor bean seeds elicited with exogenous SA, finding that the peak ricinine concentration occurred at 300 muM of SA. Elicitation with SA did not affect plant height or diameter, suggesting that it could be a cost-effective technique for increasing ricinine in castor bean bagasse.
Article
Agricultural Engineering
Mayra Denise Herrera, Rafael Jimenez-Ocampo, Rigoberto Rosales-Serna, Jorge Alberto Rodriguez-Gonzalez, Juan Luis Santos-De la Cruz, Raquel Karina Cruz-Bravo, Pablo Alvarado-Aguilar, Claudia Ivette Gamboa-Gomez, Fernando Guerrero-Romero
Summary: The study aimed to evaluate a thermal-detoxified method for castor bean toxic waste and determine the nutraceutical potential of castor bean cake. Results showed over 99% reduction in ricin concentration, LD50 of castor bean cake greater than 5000 mg/kg, increased protein content by 17.5%, decreased lipids by 10%, and enriched content of bioactive compounds.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Applied
Jolanta Ciesla, Magdalena Koczanska, Piotr Pieczywek, Justyna Cybulska, Artur Zdunek
Summary: The research investigated the effect of pectin concentration on gelation process, revealing that an increase in concentration leads to self-assembling and cross-linking processes, altering the physicochemical properties of pectin.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Inorganic & Nuclear
Rakesh Kumar, Ayushi Awasthi, Sikha Gupta, Raju Eerlapally, Apparao Draksharapu
Summary: In this study, a synthetic Ru-III-OCl species was reported as a structural mimic of haloperoxidase enzymes. This species can persist for a certain period of time at room temperature and perform oxygen atom transfer and hydrogen atom abstraction to organic substrates.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Applied
Nguyen Kim Tuyen Pham, Thi Thao Linh Tran, Thuc Huy Duong, Nguyen Tien Trung, Dang Cam Tu Phan, Dinh Tri Mai, Van Kieu Nguyen, Bui Linh Chi Huynh, Thi Anh Tuyet Nguyen, Trong Duc Tran, Thi Ngoc Mai Tran, Tan Phat Nguyen
Summary: A new alkaloid, ricicomin A, was identified from the leaves of Ricinus communis Linn., along with three known alkaloids. Chemical structures were confirmed using various analytical methods. Compound 4 was discovered for the first time in the genus Ricinus, and DFT-NMR calculations were used to confirm the structure of compound 1. However, compounds 1-3 did not exhibit cytotoxic effects on three human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Magnus R. Buchner, Matthias Mueller
Summary: An aluminum-based adjuvant for vaccines and beryllium ions interact with the same immune receptor. Beryllium oxocarboxylates have a Be4O core, which may be the binding species. A synthetic route to beryllium oxocarboxylates has been developed to investigate the influence of ligands on their molecular and spectroscopic properties. The ligands only slightly perturb the C-C distances, with Be-O bands observed in vibrational spectroscopy.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anadil Gul, Fozia, Asmat Shaheen, Ijaz Ahmad, Baharullah Khattak, Munir Ahmad, Riaz Ullah, Ahmed Bari, Syed Saeed Ali, Abdulrahman Alobaid, Majid M. Asmari, Hafiz M. Mahmood
Summary: This study focused on the cost-effective and environmentally friendly synthesis of Ag nanoparticles using leaf and root extracts of Ricinus communis as reducing and stabilizing agents. The synthesized nanoparticles showed promising antibacterial/fungicidal activity and stability in various pH environments. The cytotoxicity of the nanoparticles was found to be biologically compatible below a concentration of 20 μg/mL.
Article
Plant Sciences
Jinghong Wang, Xiaoyuan Peng, Yu Gao, Yingnan Wang, Jixiang Lin, Xiufeng Yan
Summary: The study found that alkaline stress inhibited seedling growth, particularly in the roots. Proline and soluble sugars increased in cotyledons, while remaining unchanged in the roots under alkaline stress. Proteomic analysis revealed 15 and 25 alkaline-responsive proteins in the cotyledons and roots, respectively.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Genetics & Heredity
Masatake Kanai, Kazumi Hikino, Shoji Mano
Summary: Castor seeds are a rich source of ricinoleic acid, which is highly valuable for the production of plant-based products. However, the presence of toxic protein ricin in the seeds hampers further expansion in castor cultivation. This study identified six U6 snRNA genes in the castor genome and examined their function in activating gene expression. The results provide useful insights into the endogenous U6 promoter sequences in castor and offer a method for verifying U6 promoter function in plants using the particle delivery system.
Article
Chemistry, Physical
Bernard Mravec, Anna Marini, Matteo Tommasini, Juraj Filo, Marek Cigan, Mariachiara Mantero, Silvano Tosi, Maurizio Canepa, Andrea Bianco
Summary: Photochromic hydrazones are of interest in the field of photochromic systems due to their P-type character. Studies have shown the presence of two distinct rotamers with different energy in their structure, with higher selectivity observed in the Z form based on IR and Raman spectra analysis. The experimental results are in good agreement with theoretical predictions, especially in the case of the Raman spectrum.
Article
Chemistry, Physical
Prathvi, S. Asha Bhandarkar, Akshayakumar Kompa, Dhananjaya Kekuda, M. S. Murari, Maksim P. Telenkov, K. K. Nagaraja, K. Mohan Rao
Summary: The study found that with increasing Zn2+ concentration, the crystallite size of anatase phase in the thin films decreased, light absorption increased, and the bandgap narrowed. FESEM revealed a homogeneous distribution of grains in the films.
SURFACES AND INTERFACES
(2021)
Article
Materials Science, Ceramics
Mioara Zagrai, Sergiu Macavei, Simona Rada, Maria Elena Pica, Stela Maria Pruneanu
Summary: The trivalent gadolinium doped lead-lead dioxide glass has been successfully fabricated and investigated for its structural, optical, and luminescence properties. The addition of Gd2O3 content affects the structural units of the glass and the environment of Gd3+ ions, leading to emissions corresponding to Gd3+ ions transitions. The glass is suggested for warm orange luminescence applications based on CIE color coordinates.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Plant Sciences
Shawkat M. Ahmed, Ahmed Noureldeen
Summary: This study conducted molecular characterization and phylogenetic analysis of Chrozophora oblongifolia and Ricinus communis using ITS, ITS2, rbcLa, and matK sequences. The rbcLa locus had more variable sites and indicated an accelerated evolution in the R. communis genome. The analyses suggested that the ITS2 mini-barcode is a universal barcode for the rapid and accurate identification of Euphorbiaceous species with medicinal importance.
PAKISTAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Applied
Yan Ling Xue, Feng Zhu, Jun Wang, Shiyu Sun, Lili Hu, Dingyuan Tang
Summary: Transparent Er:Y2O3 ceramics with sub-micron grain size were fabricated using vacuum sintering followed by hot isostatic pressing technique. The structural characteristics and spectroscopic properties of the ceramics were systematically studied.
JOURNAL OF RARE EARTHS
(2022)
Article
Chemistry, Organic
Tomas Horsten, Flip de Jong, Dries Theunissen, Mark Van der Auweraer, Wim Dehaen
Summary: This study explored the potential of 1,2,3-triazolium salts for the formation of water-soluble chromophores. The synthesis of water-soluble 1,2,3-triazolium BOPAHY dyes was achieved by a metal-free pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Hannah M. Rhoda, Alexander J. Heyer, Benjamin E. R. Snyder, Dieter Plessers, Max L. Bols, Robert A. Schoonheydt, Bert F. Sels, Edward Solomon
Summary: Second-sphere interactions play a crucial role in the high activity and selectivity of transition-metal-exchanged zeolites, despite the differences in active-site structures compared to metalloenzymes.
Article
Chemistry, Physical
Edward Solomon, Anex Jose
Summary: This paper provides an overview of the unique spectroscopic features of metal sites in biology, reflecting novel geometric and electronic structures imposed by the protein; it introduces the example of the blue copper active site and its significance in biological electron transfer; it also demonstrates the role of the protein in the geometric and electronic structure of the active site.
FARADAY DISCUSSIONS
(2022)
Article
Biochemistry & Molecular Biology
Yang Ha, Sara A. Dille, Augustin Braun, Kyle Colston, Britt Hedman, Keith O. Hodgson, Partha Basu, Edward I. Solomon
Summary: This study investigates the bonding descriptions and geometric structures of oxidized dithiolene complexes bound to low-valent late transition metal ions, such as Zn-II, Cu-I, and Cu-II, using a combination of S K-edge X-ray absorption spectroscopy and density functional theory calculations. The study quantifies the competition between ligand-ligand repulsion and changes in electronic structures in determining the final geometric structures of the complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Correction
Instruments & Instrumentation
Diego A. Huyke, Ashwin Ramachandran, Oscar Ramirez-Neri, Jose A. Guerrero-Cruz, Leland B. Gee, Augustin Braun, Dimosthenis Sokaras, Brenda Garcia-Estrada, Edward I. Solomon, Britt Hedman, Mario U. Delgado-Jaime, Daniel P. DePonte, Thomas Kroll, Juan G. Santiago
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Multidisciplinary Sciences
Ioannis Kipouros, Agnieszka Stanczak, Jake W. Ginsbach, Prokopis C. Andrikopoulos, Lubomir Rulsek, Edward I. Solomon
Summary: Melanins are important biopolymer pigments that provide photoprotection, and their biosynthesis involves the catalytic role of tyrosinase (Ty). This study combines spectroscopic, kinetic, and computational methods to investigate the mechanism of the rate-limiting step in melanin biosynthesis. The results provide insights into the O-2 activation and reactivity by the active sites of coupled binuclear copper, with implications in biocatalysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Ioannis Kipouros, Edward I. Solomon
Summary: Tyrosinase, a member of the CBC protein family, has been studied extensively. Recent research has revealed the structure of a catalytic ternary intermediate and proposed a revised mechanism for monophenol monooxygenation. These findings are significant for understanding structure-function relationships in CBC enzymes and the activation of O-2 in bioinorganic active sites.
Article
Chemistry, Inorganic & Nuclear
Wesley J. Transue, Rae Ana Snyder, Jonathan D. Caranto, Donald M. Kurtz Jr, Edward I. Solomon
Summary: This paper describes a particle swarm optimization (PSO) algorithm for fitting ground-state spin Hamiltonian parameters from variable-temperature/variable-field magnetic circular dichroism (MCD) data. The PSO algorithm is used to determine the ground state of two catalytic intermediates from a flavodiiron protein with nitric oxide reductase activity. The fits of the spin Hamiltonians provide important geometric and electronic insight into these species.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Dieter Plessers, Alexander J. Heyer, Hannah M. Rhoda, Max L. Bols, Edward I. Solomon, Robert A. Schoonheydt, Bert F. Sels
Summary: The industrial implementation of a direct methane-to-methanol process would bring about environmental and economic benefits. Copper zeolites can effectively catalyze this reaction at lower temperatures, especially mordenite zeolites which enable high methanol production. By changing the co-cation, a new method for simplifying the material is introduced, allowing for better analysis, which has implications for the study and tuning of heterogeneous catalysts in general.
Article
Chemistry, Multidisciplinary
Bohee Kim, Magdalene T. T. Brueggemeyer, Wesley J. J. Transue, Younwoo Park, Jaeheung Cho, Maxime A. A. Siegler, Edward I. I. Solomon, Kenneth D. D. Karlin
Summary: Lytic polysaccharide monooxygenases are important in converting biomass to biofuel, and recent studies show that their peroxygenase activity using H2O2 as an oxidant is more important than their monooxygenase functionality. New insights into this activity have been described, including ligand-substrate hydroxylation and Fenton-type chemistry reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jeffrey T. T. Babicz Jr, Melanie S. Rogers, Dory E. DeWeese, Kyle D. Sutherlin, Rahul Banerjee, Lars H. Bottger, Yoshitaka Yoda, Nobumoto Nagasawa, Makina Saito, Shinji Kitao, Masayuki Kurokuzu, Yasuhiro Kobayashi, Kenji Tamasaku, Makoto Seto, John D. Lipscomb, Edward I. Solomon
Summary: The extradiol dioxygenases and intradiol dioxygenases play a crucial role in the carbon cycle by catalyzing oxidative aromatic ring cleavage. This study investigates the mechanisms behind their regiospecificity in cleavage, using EDO and IDO enzymes as models. The results reveal the structural and electronic properties of key intermediates and propose a viable mechanism for intradiol cleavage.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Augustin Braun, Leland B. Gee, Michael W. Mara, Ethan A. Hill, Thomas Kroll, Dennis Nordlund, Dimosthenis Sokaras, Pieter Glatzel, Britt Hedman, Keith O. Hodgson, A. S. Borovik, Michael L. Baker, Edward I. Solomon
Summary: Fe K-edge XAS is widely used for studying high-valent iron intermediates in catalysts. The 4p-mixing into the 3d orbitals complicates the analysis, but understanding it correctly enables deeper insights into the structure and reactivity. This study reveals that the loss of inversion in the equatorial plane leads to 4p mixing into the 3dx2-y2,xy orbitals, providing structural insights for distinguishing 6- vs 5-coordinate active sites. Furthermore, the study investigates the electronic structure of Fe(IV)=O active sites and their reactivity selectivity through O K-edge XAS.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Casey Van Stappen, Huiguang Dai, Anex Jose, Shiliang Tian, Edward I. Solomon, Yi Lu
Summary: This research investigates the influence of the primary and secondary coordination sphere on CuII-catalyzed S-nitrosylation. The study reveals that kinetic competency is correlated with Cu-S bond strength, Cu spin localization, and relative S(p(s)) vs S(p(p)) contributions to the ground state.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hyeongtaek Lim, Magdalene T. Brueggemeyer, Wesley J. Transue, Katlyn K. Meier, Stephen M. Jones, Thomas Kroll, Dimosthenis Sokaras, Bradley Kelemen, Britt Hedman, Keith O. Hodgson, Edward I. Solomon
Summary: This study investigates the electronic structure of the d(10) Cu(I) active site in LPMO using Kβ X-ray emission spectroscopy (XES). The lack of inversion symmetry in the His-brace site enables the required 3d/p mixing for intensity in the Kβ valence-to-core (VtC) XES spectrum of Cu(I)-LPMO. These Kβ XES data are correlated to density functional theory (DFT) calculations to define the bonding, particularly the frontier molecular orbital (FMO) of the Cu(I) site. These experimentally validated DFT calculations are used to evaluate the reaction coordinate for homolytic cleavage of the H2O2 O-O bond and understand the activation of the geometric and electronic structure of the Cu(I)-LPMO site for rapid reactivity with H2O2.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Asmita Singha, Alina Sekretareva, Lizhi Tao, Hyeongtaek Lim, Yang Ha, Augustin Braun, Stephen M. Jones, Britt Hedman, Keith O. Hodgson, R. David Britt, Daniel J. Kosman, Edward I. Solomon
Summary: In multicopper oxidases (MCOs), the T1 Cu accepts electrons from the substrate and transfers them to the TNC, reducing O-2 to H2O. The literature fails to explain the wide range of T1 potentials in MCOs, ranging from 340 to 780 mV. This study focuses on the difference in potential of the T1 center in Fet3p and Trametes versicolor laccase (TvL) that have the same ligand set, and reveals that second-sphere H-bonding interactions and carboxylate residues significantly lower the T1 potential.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ioannis Kipouros, Agnieszka Stanczak, Martin Culka, Erik Andris, Timothy R. Machonkin, Lubomir Rulisek, Edward Solomon
Summary: This study reveals the H-bonding interactions between active-site waters and the mu-eta(2):eta(2)-peroxide of oxy-tyrosinase, and defines their effects on the Cu(ii)(2)O-2 electronic structure and O-2 activation using spectroscopic and computational methods.
CHEMICAL COMMUNICATIONS
(2022)