Article
Nanoscience & Nanotechnology
Xiangle Zeng, Hairong Wang, Yawen Zhang, Xue Xu, Xinyi Yuan, Jianchun Li
Summary: This study developed a nanomicelle formulation (HDO-NPs) by combining dasatinib and olaparib, which exhibited synergistic effects on triple negative breast cancer by inducing DNA damage and inhibiting DNA damage repair. HDO-NPs were able to effectively target tumor tissues, improve drug bioavailability, and demonstrate excellent therapeutic effects both in vitro and in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Ningning Song, Bo Li, Dandan Li, Yunwen Yan
Summary: In this study, a Zr-based metal-organic framework (MOF) modified with hyaluronic acid (HA) was developed for two-photon activated photodynamic therapy (PDT) in triple negative breast cancer (TNBC). The composite ZrTc@HA exhibited significant two-photon activity and excellent light-triggered reactive oxygen species generation ability. It can serve as a diagnostic probe for fluorescence imaging and a therapeutic agent for PDT, showing great potential for monotherapy and synergistic phototherapy in TNBC.
Article
Multidisciplinary Sciences
Wanfu Wu, Margaret Warner, Li Wang, Wei-Wei He, Ruipeng Zhao, Xiaoxiang Guan, Cindy Botero, Bo Huang, Charlotte Ion, Charles Coombes, Jan-Ake Gustafsson
Summary: Comparing gene expression profiles of malignant parts and normal adjacent parts of TNBC breasts revealed that CYP-mediated pathways may drive TNBC. However, despite being expressed in TNBC, ER13 is unlikely to be a tumor suppressor as its absence of main tethering partners renders it ineffective on genes related to proliferation and inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Yingpeng Li, Liang Liu, Hongtao Shang, Xuchen Feng, Ni Fan, Jingyu Wang, Yuqi Wu, Yatong Chen, Xinhong Chu, Min Zhong, Yujiao Sun, Hui Fu, Wei Huang, Yunfei Li
Summary: This study reports a chitosan-based hyaluronic acid nanoparticle that self-assembles and effectively treats triple-negative breast cancer in vivo. The nanoparticle targets tumor cells and improves the bioavailability of the drug, offering a new strategy for the treatment of triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Vellingiri Yasothamani, Laxmanan Karthikeyan, Selvaraj Shyamsivappan, Yuvaraj Haldorai, Dayakar Seetha, Raju Vivek
Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.
Article
Biochemistry & Molecular Biology
Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J. Cowley, Kristin K. Brown, Nigel Turner, Andrew J. Hoy, Jeff Holst
Summary: This study reveals that glutamine-indispensable triple-negative breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, which increases TCA cycle fluxes and replenishes TCA cycle intermediates. The coupling of glucose and glutamine catabolism hampers TNBC cells' ability to oxidize glucose when glutamine is limiting.
Letter
Medicine, General & Internal
Ryan Sun, Lee-Jen Wei
Summary: This article discusses the clinical benefits of pembrolizumab combined with chemotherapy in patients with triple-negative breast cancer. The authors suggest that both hazard values and ratios should be considered when evaluating clinical benefits.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hung-Wei Cheng, Chih-Sheng Chiang, Hsin-Yao Ho, Syun-Hong Chou, Yen-Ho Lai, Woei-Cherng Shyu, San-Yuan Chen
Summary: Precision cancer nanomedicine based on natural therapeutic materials has been developed to tackle serious side effects from chemotherapies. A novel nanomedicine, CuQDA/IO@HA, composed of hyaluronic acid (HA) / copper ion (Cu(II))-chelated dextran-aldehyde (DA)-quercetin (Q) with dual targeting for synthetic lethal therapy, has shown promising results in specifically targeting and inducing cytotoxicity in BRCA-mutant cancer cells.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Sofia Valla, Nourhan Hassan, Daiana Lujan Vitale, Daniela Madanes, Fiorella Mercedes Spinelli, Felipe C. O. B. Teixeira, Burkhard Greve, Nancy Adriana Espinoza-Sanchez, Carolina Cristina, Laura Alaniz, Martin Goette
Summary: The study focused on the impact of Sdc-1 knockdown and HA treatment on breast cancer cell behavior, showing differential effects on HA metabolism in luminal and triple-negative breast cancer model cell lines. Sdc-1 depletion influenced cell survival, stem phenotype, and angiogenic factors through altered gene expression and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Yuanjiang Wang, Zhaodan Lv, Feihong Chen, Xing Wang, Shaohua Gou
Summary: A new compound 3a was synthesized to inhibit TNBC stem cells and reverse drug resistance in MDA-MB-231 cells induced by lapatinib. It effectively suppressed tumor invasion and migration by inhibiting relevant signaling pathways and protein expression, proving to be a potential dual inhibitor for EGFR and CSC in TNBC treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala, Yao Tang, Ji Qi, Yun-Sheng Chen, Zhou Gao, Kerriann M. Casey, Arkadiy A. Bazhin, Min Chen, Leeann Hu, Jinghang Xie, Mingxi Fang, Cissy Zhang, Qihua Zhu, Zhiyuan Wang, Amato J. Giaccia, Sanjiv Sam Gambhir, Weiping Zhu, Dean W. Felsher, Mark D. Pegram, Elena A. Goun, Anne Le, Jianghong Rao
Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.
NATURE BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Maisa Siddiq Abduh
Summary: This study developed a novel drug delivery technique based on a polymeric nanoformulation to improve the delivery and efficacy of Cyclosporine in cancer treatment. The results showed that the formulated nanoparticles had good particle size and stability, and demonstrated strong inhibitory effects on breast cancer cells in vitro.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Arijita Basu, Priyanka Upadhyay, Avijit Ghosh, Aparajita Bose, Payal Gupta, Sreya Chattopadhyay, Dipankar Chattopadhyay, Arghya Adhikary
Summary: HA-GO-Met nanoparticles exhibit significant anti-cancer efficacy in triple negative breast cancer, inducing apoptosis and inhibiting cell migration by targeting the miR-10b/PTEN axis via NFkB-p65. They also reduce tumor load and overall toxicity, inhibit epithelial mesenchymal transition and stemness, addressing the issue of cancer recurrence.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Nanoscience & Nanotechnology
Xiangpeng Wang, Yurong Song, Liuchunyang Yu, Xiaoxia Xue, Mingshi Pang, Yang Li, Xinyi Luo, Zhenglai Hua, Cheng Lu, Aiping Lu, Yuanyan Liu
Summary: This study developed a modified drug delivery system called CDDP-HA-Lip/Hes for the treatment of triple-negative breast cancer (TNBC). The system effectively targeted TNBC and its metastasis, while also reducing systemic toxicity. It was found that the system inhibited inflammation and epithelial-mesenchymal transition (EMT), improving chemosensitivity and inhibiting tumor metastasis. Additionally, the system showed minimal side effects on normal tissues.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xiaoxiao Chen, Wenqiang Du, Ze Cai, Shengyun Ji, Monika Dwivedi, Jianfeng Chen, Gang Zhao, Jiaru Chu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Correction
Materials Science, Biomaterials
Pankaj Dwivedi, Shuya Han, Farhana Mangrio, Rong Fan, Monika Dwivedi, Zhiqiang Zhu, Fangsheng Huang, Qiang Wu, Renuka Khatik, David E. Cohn, Ting Si, Shuiying Hu, Alex Sparreboom, Ronald X. Xu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Pankaj Dwivedi, Sonia Kiran, Shuya Han, Monika Dwivedi, Renuka Khatik, Rong Fan, Farhana Akbar Mangrio, Kun Du, Zhiqiang Zhu, Chaoyu Yang, Fangsheng Huang, Aslam Ejaz, Renzhi Han, Ting Si, Ronald Xu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Pharmacology & Pharmacy
Poonam Parashar, Surabhi Pal, Monika Dwivedi, Shubhini A. Saraf
Article
Cell Biology
Upendra Kumar Soni, Sangappa Basanna Chadchan, Anubha Joshi, Vijay Kumar, Vineet Kumar Maurya, Raj Kumar Verma, Rajesh Kumar Jha
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Cell Biology
Sangappa B. Chadchan, Vineet K. Maurya, Gwendalyn L. Krekeler, Emily S. Jungheim, Ramakrishna Kommagani
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Reproductive Biology
Sangappa B. Chadchan, Pooja Popli, Vineet K. Maurya, Ramakrishna Kommagani
Summary: ACE2 protein expression in the endometrium varies during the menstrual cycle and plays a crucial role in uterine physiology. This suggests that SARS-CoV-2 may affect endometrial stromal cells and potentially lead to pathological manifestations in women with COVID-19.
BIOLOGY OF REPRODUCTION
(2021)
Article
Developmental Biology
Upendra Kumar Soni, Sangappa Basanna Chadchan, Rakesh Kumar Gupta, Vijay Kumar, Rajesh Kumar Jha
Summary: miR-149 plays a crucial role in regulating endometrial receptivity and decidualization for trophoblast implantation by targeting PARP-2 and caspase-8 proteins in endometrial cells.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Raj Kumar Verma, Upendra Kumar Soni, Sangappa Basanna Chadchan, Vineet Kumar Maurya, Mohini Soni, Sudarsan Sarkar, J. Venkatesh Pratap, Rajesh Kumar Jha
Summary: E-cadherin is predominantly expressed during the pre-receptive stage of endometrial receptivity and is promoted by PARP-2, which is regulated by miR-149. On the other hand, N-cadherin is only detected at the early stages and decreases thereafter.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma
Summary: Functional retinoic acid (RA) signaling is crucial for female fertility, especially implantation and decidualization, as shown by genetic mouse models and human endometrial stromal cell studies. Disruption of uterine RA signaling leads to compromised fertility due to failure of uterine receptivity and decidualization.
Article
Chemistry, Organic
Jyotsana Dwivedi, Monika Dwivedi, Swati Gupta, Vishwajeet Jadaun, Babita Yadav, Poonam Parashar, Priyanka Dhar, Pankaj Dwivedi, Hafsa Ahmed, Priyam Singh, Anirban Pal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Ajay Kumar Singh Rawat
Summary: Diabetes mellitus is a metabolic threat leading to various complications, and the synthesis of plant molecular hybrids from potent biomarkers has shown potential in combating diabetes, hyperlipidemia, and oxidative stress, with PMH4 standing out as particularly effective.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biology
Sangappa B. Chadchan, Pooja Popli, Chandrasekhar R. Ambati, Eric Tycksen, Sang Jun Han, Serdar E. Bulun, Nagireddy Putluri, Scott W. Biest, Ramakrishna Kommagani
Summary: Endometriosis is a painful disease affecting millions worldwide, with studies showing that gut microbiota plays a role in its development - some bacteria promote lesion growth while others produce short-chain fatty acids to counteract it. Treatment with n-butyrate has been found to reduce the growth of lesions in both mouse and human endometriosis cases, offering potential for future diagnostic tests and treatment strategies.
LIFE SCIENCE ALLIANCE
(2021)
Review
Endocrinology & Metabolism
Sangappa B. Chadchan, Vertika Singh, Ramakrishna Kommagani
Summary: This review provides an updated overview of the relationship between the gut microbiome and female reproductive diseases. Recent studies have revealed associations between altered gut microbial compositions and gynecological pathologies such as polycystic ovarian syndrome, endometriosis, and endometrial cancer. Future research should focus on determining the molecular mechanisms underlying these associations.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sangappa B. Chadchan, Sumanta K. Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R. Ambati, Michael A. Lint, Andrew L. Kau, Christina L. Stallings, Ramakrishna Kommagani
Summary: Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites. Current methods for detecting endometriosis are invasive and ineffective in preventing recurrences. The causal role of gut microbiota and microbiota-derived metabolites in endometriosis progression is largely unknown.
CELL DEATH DISCOVERY
(2023)
Article
Chemistry, Multidisciplinary
Sonia Kiran, Pankaj Dwivedi, Renuka Khatik, Sadaf Hameed, Monika Dwivedi, Fangsheng Huang, Ronald X. Xu
CHEMICAL COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
