Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis

Associations Between Endometriosis and Gut Microbiota

(2021) Agnes Svensson et al.   Reproductive Sciences

Comparative effect of sodium butyrate and sodium propionate on proliferation, cell cycle and apoptosis in human breast cancer cells MCF-7

(2020) Josiane Semaan et al.   Breast Cancer

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice

(2020) Juneyoung Lee et al.   CIRCULATION RESEARCH

Production and Sensing of Butyrate in a Probiotic E. coli Strain

(2020) Yanfen Bai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice

(2020) Liang Bai et al.   Microbial Cell Factories

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

(2020) Zhexin Ni et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection

(2020) Hitoshi Tsugawa et al.   PLOS BIOLOGY

GPR43 REGULATES SODIUM BUTYRATE-INDUCED ANGIOGENESIS AND MATRIX REMODELING

(2020) Pollyana Ribeiro Castro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Determination and Comparison of Short-Chain Fatty Acids in Serum and Colon Content Samples: Alzheimer’s Disease Rat as a Case Study

(2020) Lin-Xiu Guo et al.   MOLECULES

Serum metabolic profiling identified a distinct metabolic signature in Bladder Cancer Smokers: A key metabolic enzymes associated with patient survival

(2019) Chandra Sekhar Amara et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Plasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis

(2019) Lindsay M. Moye et al.   Frontiers in Pediatrics

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

(2019) Nielson T. Baxter et al.   mBio

Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation

(2019) Mingming Cao et al.   Molecular Medicine Reports

Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in Bladder Cancer

(2019) Venkatrao Vantaku et al.   CLINICAL CANCER RESEARCH

Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

(2019) Sangappa B Chadchan et al.   HUMAN REPRODUCTION

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

(2019) Raphael J. F. Felizardo et al.   FASEB JOURNAL

Bidirectional regulatory potentials of short-chain fatty acids and their G-protein-coupled receptors in autoimmune neuroinflammation

(2019) Jeongho Park et al.   Scientific Reports

Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

(2019) Yaoyu Pu et al.   Aging-US

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

(2019) Hernández et al.   Nutrients

Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections

(2019) Pilar García-Peñarrubia et al.   HUMAN REPRODUCTION UPDATE

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation

(2019) Josefine Hantschel et al.   PLoS One

Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome

(2018) Monica S. Spychala et al.   ANNALS OF NEUROLOGY

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Endometriosis induces gut microbiota alterations in mice

(2018) Ming Yuan et al.   HUMAN REPRODUCTION

Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation

(2018) Brinda Bhatt et al.   JOURNAL OF IMMUNOLOGY

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

(2018) Amir Zarrinpar et al.   Nature Communications

The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

(2018) Meng Li et al.   Frontiers in Pharmacology

Implication of G Protein-Coupled Receptor 43 in Intestinal Inflammation: A Mini-Review

(2018) Guan Yang et al.   Frontiers in Immunology

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Microbial metabolite sensor GPR43 controls severity of experimental GVHD

(2018) Hideaki Fujiwara et al.   Nature Communications

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

(2018) Zhendong Li et al.   Frontiers in Cellular and Infection Microbiology

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

(2018) Zhi Y. Kho et al.   Frontiers in Microbiology

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

(2018) Stephanie A. Michalski et al.   Jove-Journal of Visualized Experiments

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

(2018) Abdul Malik Tyagi et al.   IMMUNITY

Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization

(2017) Alison J. Camden et al.   MOLECULAR HUMAN REPRODUCTION

The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

(2017) Chen Chen et al.   Nature Communications

Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine

(2017) Yukiko K. Nakamura et al.   Scientific Reports

Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome

(2017) Kazuchika Nishitsuji et al.   Scientific Reports

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

(2017) Meike Kespohl et al.   Frontiers in Immunology

Roles of Rap1 signaling in tumor cell migration and invasion

(2017) Zhang Yi-Lei et al.   Cancer Biology & Medicine

Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis

(2017) Hesham Aly Salem et al.   Scientific Reports

Surgery accelerates the development of endometriosis in mice

(2016) Qiqi Long et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Rediscovering peritoneal macrophages in a murine endometriosis model

(2016) Ming Yuan et al.   HUMAN REPRODUCTION

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

The role of Gut Microbiota in the development of obesity and Diabetes

(2016) Othman A. Baothman et al.   Lipids in Health and Disease

Increased Risk of Endometriosis in Patients With Lower Genital Tract Infection

(2016) Wu-Chou Lin et al.   MEDICINE

The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization

(2016) Ramakrishna Kommagani et al.   PLoS Genetics

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis

(2015) Sang Jun Han et al.   CELL

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

(2015) Ningwen Tai et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Pathophysiology and Immune Dysfunction in Endometriosis

(2015) Soo Hyun Ahn et al.   Biomed Research International

Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis†

(2014) Khaleque Newaz Khan et al.   HUMAN REPRODUCTION

The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis

(2014) Sang Jun Han et al.   HUMAN REPRODUCTION UPDATE

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

(2014) Mathieu Pizzonero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

The Expression of Histone Deacetylase 1, But Not Other Class I Histone Deacetylases, Is Significantly Increased in Endometriosis

(2013) Eleftherios P. Samartzis et al.   Reproductive Sciences

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

(2012) L B Bindels et al.   BRITISH JOURNAL OF CANCER

Creation of immortalised epithelial cells from ovarian endometrioma

(2012) Y Bono et al.   BRITISH JOURNAL OF CANCER

Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin

(2011) Patrick Imesch et al.   FERTILITY AND STERILITY

Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study

(2011) Tine Jess et al.   GUT

Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target

(2011) Y. Kawano et al.   HUMAN REPRODUCTION

Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression

(2011) Dag Henrik Reikvam et al.   PLoS One

Downregulation of Rap1GAP through Epigenetic Silencing and Loss of Heterozygosity Promotes Invasion and Progression of Thyroid Tumors

(2010) H. Zuo et al.   CANCER RESEARCH

Influence of the type of indigestible carbohydrate on plasma and urine short-chain fatty acid profiles in healthy human volunteers

(2010) K Verbeke et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells

(2010) Patrick Imesch et al.   FERTILITY AND STERILITY

Downregulation of Rap1GAP in Human Tumor Cells Alters Cell/Matrix and Cell/Cell Adhesion

(2010) O. M. Tsygankova et al.   MOLECULAR AND CELLULAR BIOLOGY

Endometriosis

(2010) Linda C. Giudice   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease

(2009) Monica Bacci et al.   AMERICAN JOURNAL OF PATHOLOGY

Down-regulation of Rap1GAP via Promoter Hypermethylation Promotes Melanoma Cell Proliferation, Survival, and Migration

(2009) H. Zheng et al.   CANCER RESEARCH

Activation of Rap1 Promotes Prostate Cancer Metastasis

(2009) C. L. Bailey et al.   CANCER RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Rap1GAP Promotes Invasion via Induction of Matrix Metalloproteinase 9 Secretion, Which Is Associated with Poor Survival in Low N-Stage Squamous Cell Carcinoma

(2008) R. S. Mitra et al.   CANCER RESEARCH

Loss of Rap1GAP in Papillary Thyroid Cancer

(2008) Anoma Nellore et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM