DNA nanotechnology from the test tube to the cell

Enzymatic Synthesis of Periodic DNA Nanoribbons for Intracellular pH Sensing and Gene Silencing

(2015) Gang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami

(2015) Benjamin Kick et al.   NANO LETTERS

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

Virus-Inspired Membrane Encapsulation of DNA Nanostructures To Achieve In Vivo Stability

(2014) Steven D. Perrault et al.   ACS Nano

Addressing the Instability of DNA Nanostructures in Tissue Culture

(2014) Jaeseung Hahn et al.   ACS Nano

Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability

(2014) Harry M. T. Choi et al.   ACS Nano

Catalytic 1,4-Rhodium(III) Migration Enables 1,3-Enynes to Function as One-Carbon Oxidative Annulation Partners in CH Functionalizations

(2014) David J. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells

(2014) Le Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toehold Switches: De-Novo-Designed Regulators of Gene Expression

(2014) Alexander A. Green et al.   CELL

Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy

(2014) Mingxu You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery

(2014) Joona Mikkilä et al.   NANO LETTERS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

(2014) Ralf Jungmann et al.   NATURE METHODS

Universal computing by DNA origami robots in a living animal

(2014) Yaniv Amir et al.   Nature Nanotechnology

In vivoco-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner

(2014) Gairik Sachdeva et al.   NUCLEIC ACIDS RESEARCH

Design and application of cotranscriptional non-enzymatic RNA circuits and signal transducers

(2014) Sanchita Bhadra et al.   NUCLEIC ACIDS RESEARCH

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

(2014) Tiffany L. Halo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-stranded architecture for cotranscriptional folding of RNA nanostructures

(2014) C. Geary et al.   SCIENCE

Genomically encoded analog memory with precise in vivo DNA writing in living cell populations

(2014) F. Farzadfard et al.   SCIENCE

Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor

(2013) Jonathan R. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

(2013) Kyoung-Ran Kim et al.   CHEMICAL COMMUNICATIONS

Conditional Dicer Substrate Formation via Shape and Sequence Transduction with Small Conditional RNAs

(2013) Lisa M. Hochrein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Computation in Mammalian Cells: MicroRNA Logic Operations

(2013) James Hemphill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA “Nano-Claw”: Logic-Based Autonomous Cancer Targeting and Therapy

(2013) Mingxu You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA

(2013) Sherry Xi Chen et al.   Nature Chemistry

Visualizing SNVs to quantify allele-specific expression in single cells

(2013) Marshall J Levesque et al.   NATURE METHODS

Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides

(2013) Cosimo Ducani et al.   NATURE METHODS

Programmable chemical controllers made from DNA

(2013) Yuan-Jyue Chen et al.   Nature Nanotechnology

Activation of different split functionalities on re-association of RNA–DNA hybrids

(2013) Kirill A. Afonin et al.   Nature Nanotechnology

Autonomous molecular cascades for evaluation of cell surfaces

(2013) Maria Rudchenko et al.   Nature Nanotechnology

Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell

(2013) Souvik Modi et al.   Nature Nanotechnology

Quantitative assessment of ratiometric bimolecular beacons as a tool for imaging single engineered RNA transcripts and measuring gene expression in living cells

(2013) Xuemei Zhang et al.   NUCLEIC ACIDS RESEARCH

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

(2013) G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents

(2013) Ali H. Alhasan et al.   Small

A library of programmable DNAzymes that operate in a cellular environment

(2013) Maya Kahan-Hanum et al.   Scientific Reports

Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

(2012) Kohta Mohri et al.   ACS Nano

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Reconfigurable Three-Dimensional DNA Nanostructures for the Construction of Intracellular Logic Sensors

(2012) Hao Pei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA nanostructure serum stability: greater than the sum of its parts

(2012) Justin W. Conway et al.   CHEMICAL COMMUNICATIONS

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines

(2012) Xiaowei Liu et al.   NANO LETTERS

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

A DNA-based molecular motor that can navigate a network of tracks

(2012) Shelley F. J. Wickham et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures

(2012) M. Langecker et al.   SCIENCE

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Programmed Cell-to-Cell Variability in Ras Activity Triggers Emergent Behaviors during Mammary Epithelial Morphogenesis

(2012) Jennifer S. Liu et al.   Cell Reports

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures

(2011) Verena J. Schüller et al.   ACS Nano

DNA Cage Delivery to Mammalian Cells

(2011) Anthony S. Walsh et al.   ACS Nano

Aptamer-Conjugated DNA Icosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy

(2011) Microsugar Chang et al.   ACS Nano

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Combinatorially Inducible RNA Interference Triggered by Chemically Modified Oligonucleotides

(2011) Deepak Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Programmable Molecular Robot

(2011) Richard A. Muscat et al.   NANO LETTERS

Stability of DNA Origami Nanoarrays in Cell Lysate

(2011) Qian Mei et al.   NANO LETTERS

Neural network computation with DNA strand displacement cascades

(2011) Lulu Qian et al.   NATURE

A primer to scaffolded DNA origami

(2011) Carlos Ernesto Castro et al.   NATURE METHODS

Synthetic RNA–protein complex shaped like an equilateral triangle

(2011) Hirohisa Ohno et al.   Nature Nanotechnology

Configuring robust DNA strand displacement reactions for in situ molecular analyses

(2011) Dzifa Y. Duose et al.   NUCLEIC ACIDS RESEARCH

Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

(2011) C. J. Delebecque et al.   SCIENCE

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

(2011) L. Qian et al.   SCIENCE

Design, Assembly, and Activity of Antisense DNA Nanostructures

(2011) Jung-Won Keum et al.   Small

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Single-Molecule Kinetics and Super-Resolution Microscopy by Fluorescence Imaging of Transient Binding on DNA Origami

(2010) Ralf Jungmann et al.   NANO LETTERS

Molecular robots guided by prescriptive landscapes

(2010) Kyle Lund et al.   NATURE

Programmable in situ amplification for multiplexed imaging of mRNA expression

(2010) Harry M T Choi et al.   NATURE BIOTECHNOLOGY

A polyhedron made of tRNAs

(2010) Isil Severcan et al.   Nature Chemistry

In vitro assembly of cubic RNA-based scaffolds designed in silico

(2010) Kirill A. Afonin et al.   Nature Nanotechnology

Training a molecular automaton to play a game

(2010) Renjun Pei et al.   Nature Nanotechnology

DNA computing circuits using libraries of DNAzyme subunits

(2010) Johann Elbaz et al.   Nature Nanotechnology

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells

(2010) Antony K. Chen et al.   NUCLEIC ACIDS RESEARCH

Logic integration of mRNA signals by an RNAi-based molecular computer

(2010) Zhen Xie et al.   NUCLEIC ACIDS RESEARCH

Nano-flares for mRNA Regulation and Detection

(2009) Andrew E. Prigodich et al.   ACS Nano

Fluorescent Probes for Live-Cell RNA Detection

(2009) Gang Bao et al.   Annual Review of Biomedical Engineering

The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity

(2009) Sakulrat Rattanakiat et al.   BIOMATERIALS

Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

(2009) Yonggang Ke et al.   NANO LETTERS

Self-assembly of DNA into nanoscale three-dimensional shapes

(2009) Shawn M. Douglas et al.   NATURE

From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal

(2009) Jianping Zheng et al.   NATURE

Self-assembly of a nanoscale DNA box with a controllable lid

(2009) Ebbe S. Andersen et al.   NATURE

The changing economics of DNA synthesis

(2009) Robert Carlson   NATURE BIOTECHNOLOGY

Single molecule–sensitive probes for imaging RNA in live cells

(2009) Philip J Santangelo et al.   NATURE METHODS

A DNA nanomachine that maps spatial and temporal pH changes inside living cells

(2009) Souvik Modi et al.   Nature Nanotechnology

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Hybridization kinetics is different inside cells

(2009) I. Schoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

(2009) Z. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folding DNA into Twisted and Curved Nanoscale Shapes

(2009) H. Dietz et al.   SCIENCE

A Bipedal DNA Brownian Motor with Coordinated Legs

(2009) Tosan Omabegho et al.   SCIENCE

DNA Nanotubes as Combinatorial Vehicles for Cellular Delivery

(2008) SeungHyeon Ko et al.   BIOMACROMOLECULES

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation

(2008) Makiya Nishikawa et al.   IMMUNOLOGY

Dynamic Allosteric Control of Noncovalent DNA Catalysis Reactions

(2008) David Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

(2008) Yu He et al.   NATURE

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY