C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis

Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes

(2018) B. Liao et al.   ALLERGY

Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment

(2017) Marta Subías Hidalgo et al.   IMMUNOBIOLOGY

Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis

(2017) Griet A. Van Roey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of mas-related G-protein–coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation

(2017) Vemuri B. Reddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A C3(H20) recycling pathway is a component of the intracellular complement system

(2017) Michelle Elvington et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of epithelial cell expressed C3 in the intestine – Relevance for the pathophysiology of inflammatory bowel disease?

(2017) Annika Sünderhauf et al.   MOLECULAR IMMUNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells

(2017) Jennifer K. Mulligan et al.   International Forum of Allergy & Rhinology

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia

(2016) Abhigyan Satyam et al.   JOURNAL OF IMMUNOLOGY

Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future

(2016) Antonio M. Risitano et al.   SEMINARS IN IMMUNOLOGY

Mucous Cytokine Levels in Chronic Rhinosinusitis–Associated Olfactory Loss

(2016) Rodney J. Schlosser et al.   JAMA Otolaryngology-Head & Neck Surgery

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

(2016) Anne Rosbjerg et al.   Frontiers in Immunology

Superoxide Dismutase Reduces the Inflammatory Response to Aspergillus and Alternaria in Human Sinonasal Epithelial Cells Derived from Patients with Chronic Rhinosinusitis

(2015) Lauren A. Lawrence et al.   American Journal of Rhinology & Allergy

Immunological profiling in chronic rhinosinusitis with nasal polyps reveals distinct VEGF and GM-CSF signatures during symptomatic exacerbations

(2015) R. D. Divekar et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Vitamin D3as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis

(2015) E. Ritter Sansoni et al.   International Forum of Allergy & Rhinology

Development of Aspergillus Protease with Ovalbumin-induced Allergic Chronic Rhinosinusitis Model in the Mouse

(2014) Ji Heui Kim et al.   American Journal of Rhinology & Allergy

Impact of Intraoperative Hydrodebrider Treatment on Postoperative Sinonasal Inflammation

(2014) Sarfaraz M. Banglawala et al.   American Journal of Rhinology & Allergy

Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis

(2014) Jennifer K. Mulligan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis

(2013) Peter Valentin Tomazic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antisomnogenic cytokines, quality of life, and chronic rhinosinusitis: A pilot study

(2013) Jeremiah A. Alt et al.   LARYNGOSCOPE

Cytokine correlation between sinus tissue and nasal secretions among chronic rhinosinusitis and controls

(2013) Samuel L. Oyer et al.   LARYNGOSCOPE

Novel roles for complement receptors in T cell regulation and beyond

(2013) Claudia Kemper et al.   MOLECULAR IMMUNOLOGY

The role of complement in CD4+ T cell homeostasis and effector functions

(2013) Martin Kolev et al.   SEMINARS IN IMMUNOLOGY

Antigen-presenting cell–derived complement modulates graft-versus-host disease

(2012) Wing-Hong Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement Defects in Patients with Chronic Rhinosinusitis

(2012) Maria Q. Gaunsbaek et al.   PLoS One

Staphylococcus Aureus Enterotoxin B Contributes to Induction of Nasal Polypoid Lesions in an Allergic Rhinosinusitis Murine Model

(2011) Dae Woo Kim et al.   American Journal of Rhinology & Allergy

High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease

(2011) David W. Denning et al.   CLINICAL INFECTIOUS DISEASES

Novel roles of complement in T effector cell regulation

(2011) Peter S. Heeger et al.   IMMUNOBIOLOGY

Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis

(2011) Benjamin S. Bleier et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

(2011) Chris M. Ayers et al.   International Forum of Allergy & Rhinology

Human sinonasal epithelial cells direct dendritic function and T-cell T helper 1/T helper 2 skewing following Aspergillus exposure

(2011) Jennifer K. Mulligan et al.   International Forum of Allergy & Rhinology

Secondhand tobacco smoke exposure and chronic rhinosinusitis: A population-based case-control study

(2010) Douglas D. Reh et al.   American Journal of Rhinology & Allergy

Alterations in Gene Expression of Complement Components in Chronic Rhinosinusitis

(2010) Rodney J. Schlosser et al.   American Journal of Rhinology & Allergy

Secondhand Smoke as a Potential Cause of Chronic Rhinosinusitis

(2010) C. Martin Tammemagi et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Allergen-specific pattern recognition receptor pathways

(2010) Marsha Wills-Karp   CURRENT OPINION IN IMMUNOLOGY

Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage

(2010) Kara S. Davis et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Primed CD8+T-Cell Responses to Allogeneic Endothelial Cells Are Controlled by Local Complement Activation

(2009) H. Raedler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Innate Immunity to Aspergillus Species

(2009) S. J. Park et al.   CLINICAL MICROBIOLOGY REVIEWS

An update on the classifications, diagnosis, and treatment of rhinosinusitis

(2009) Yvonne Chan et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Dual nature of T cell–epithelium interaction in chronic rhinosinusitis

(2009) Tomasz M. Basinski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis

(2009) David D. Tieu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Complement C3a Regulates Late Asthmatic Response and Airway Hyperresponsiveness in Mice

(2009) N. Mizutani et al.   JOURNAL OF IMMUNOLOGY

A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells

(2009) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis

(2008) Moshe Yamin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis

(2008) Sung Whan Jun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Physiologic Alterations in the Murine Model after Nasal Fungal Antigenic Exposure

(2008) Ayesha N. Khalid et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY