Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development

Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens

(2018) Davide Oldrini et al.   ACS Chemical Biology

Conformations of Neisseria meningitidis serogroup A and X polysaccharides: The effects of chain length and O-acetylation

(2018) Jason Hlozek et al.   CARBOHYDRATE RESEARCH

Synthesis and Immunological Studies of Oligosaccharides that Consist of the Repeating Unit of Streptococcus pneumoniae Serotype 3 Capsular Polysaccharide

(2018) Chenghe Xiong et al.   CHEMISTRY-A EUROPEAN JOURNAL

The conformation of the mannopyranosyl phosphate repeating unit of the capsular polysaccharide of Neisseria meningitidis serogroup A and its carba-mimetic

(2018) Jesus Jimenez-Barbero et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Actoxumab + bezlotoxumab combination: what promise for Clostridium difficile treatment?

(2018) Brunella Posteraro et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chemical Synthesis of the Repeating Unit of Type II Group B Streptococcus Capsular Polysaccharide

(2018) Liming Shao et al.   JOURNAL OF ORGANIC CHEMISTRY

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

(2018) Francesco Berti et al.   MOLECULES

Synthesis of oligosaccharides related to galactomannans from Aspergillus fumigatus and their NMR spectral data

(2018) V. B. Krylov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel mouse monoclonal antibodies specifically recognize Aspergillus fumigatus galactomannan

(2018) Andrey L. Matveev et al.   PLoS One

A modular synthetic route to size-defined immunogenic Haemophilus influenzae b antigens is key to the identification of an octasaccharide lead vaccine candidate

(2018) J. Y. Baek et al.   Chemical Science

Applications and perspectives of nanomaterials in novel vaccine development

(2018) Yingbin Shen et al.   MedChemComm

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

(2018) Benjamin Schumann et al.   ACS Central Science

Emerging monoclonal antibodies against Clostridium difficile infection

(2017) Séverine Péchiné et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Capsule switching of Neisseria meningitidis sequence type 7 serogroup A to serogroup X

(2017) Xuemeng Ji et al.   JOURNAL OF INFECTION

Synthesis and Immunological Comparison of Differently Linked Lipoarabinomannan Oligosaccharide–Monophosphoryl Lipid A Conjugates as Antituberculosis Vaccines

(2017) Lizhen Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease

(2017) Madhu Emmadi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

(2017) Celina Jin et al.   LANCET

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

(2017) Juliana Alves Parente-Rocha et al.   MEDIATORS OF INFLAMMATION

Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model

(2017) Maria Vetro et al.   Nanomedicine

Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5

(2017) Marilda P. Lisboa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the synthesis of fungal antigenic oligosaccharides

(2017) Vadim B. Krylov et al.   PURE AND APPLIED CHEMISTRY

Synthesis of Group B Streptococcus type III polysaccharide fragments for evaluation of their interactions with monoclonal antibodies

(2017) Vittorio Cattaneo et al.   PURE AND APPLIED CHEMISTRY

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

(2017) Benjamin Schumann et al.   Science Translational Medicine

Memory B cell response to a PCV-13 booster in 3.5 year old children primed with either PCV-7 or PCV-13

(2017) Johannes Trück et al.   VACCINE

Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units

(2017) Yong Wu et al.   Nature Communications

Novel Solutions for Vaccines and Diagnostics To Combat Brucellosis

(2017) Satadru Sekhar Mandal et al.   ACS Central Science

Twenty Years of Mycobacterial Glycans: Furanosides and Beyond

(2016) Todd L. Lowary   ACCOUNTS OF CHEMICAL RESEARCH

Deciphering Antigenic Determinants of Streptococcus pneumoniae Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides

(2016) Andreas Geissner et al.   ACS Chemical Biology

Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate

(2016) Andrew E. Scott et al.   BIOCONJUGATE CHEMISTRY

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

(2016) Robert M. F. van der Put et al.   BIOCONJUGATE CHEMISTRY

A Second, Druggable Binding Site in UDP-Galactopyranose Mutase fromMycobacterium tuberculosis?

(2016) Yun Shi et al.   CHEMBIOCHEM

Vi capsular polysaccharide: Synthesis, virulence, and application

(2016) Xiaomei Hu et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response

(2016) Ermin Schadich et al.   CURRENT PHARMACEUTICAL DESIGN

Chemical Synthesis of the Repeating Unit of Type V Group B Streptococcus Capsular Polysaccharide

(2016) Jian Gao et al.   ORGANIC LETTERS

The Use of Pyranoside-into-Furanoside Rearrangement and Controlled O(5) → O(6) Benzoyl Migration as the Basis of a Synthetic Strategy To Assemble (1→5)- and (1→6)-Linked Galactofuranosyl Chains

(2016) Dmitry A. Argunov et al.   ORGANIC LETTERS

Pediatric Invasive Pneumococcal Disease in Guatemala City

(2016) James T. Gaensbauer et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Meningococcal disease in the Asia-Pacific region: Findings and recommendations from the Global Meningococcal Initiative

(2016) Ray Borrow et al.   VACCINE

Status of vaccine research and development for Shigella

(2016) Sachin Mani et al.   VACCINE

Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

(2016) Felix Broecker et al.   Nature Communications

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

Anti-Group B Streptococcus Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation

(2015) Alberto Nilo et al.   ACS Chemical Biology

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide ofStreptococcus pneumoniaeSerotype 4

(2015) Claney L. Pereira et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Immunological Studies of Linear Oligosaccharides of β-Glucan As Antigens for Antifungal Vaccine Development

(2015) Guochao Liao et al.   BIOCONJUGATE CHEMISTRY

Synthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues

(2015) Matteo Fusari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of nonionic substrate mimics of UDP-Galp as candidate inhibitors of UDP galactopyranose mutase (UGM)

(2015) Ramakrishna Kuppala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

(2015) Guochao Liao et al.   CHEMICAL COMMUNICATIONS

Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

(2015) Alberto Fernández-Tejada et al.   CHEMISTRY-A EUROPEAN JOURNAL

Monoclonal Antibody-Defined Specific C Epitope of Brucella O-Polysaccharide Revisited

(2015) Michel S. Zygmunt et al.   Clinical and Vaccine Immunology

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

(2015) John A. Crump et al.   CLINICAL MICROBIOLOGY REVIEWS

Improved Serodiagnosis of Bovine Brucellosis by Novel Synthetic Oligosaccharide Antigens Representing the Capping M Epitope Elements of Brucella O-Polysaccharide

(2015) John McGiven et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Pseudomonas aeruginosaBacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide

(2015) Joshua T. Thaden et al.   JOURNAL OF INFECTIOUS DISEASES

Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates

(2015) Lizhen Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of an Orthogonal Protection Strategy for the Synthesis of Mycobacterial Arabinomannan Fragments

(2015) Kamar Sahloul et al.   JOURNAL OF ORGANIC CHEMISTRY

Convergent synthesis of isomeric heterosaccharides related to the fragments of galactomannan from Aspergillus fumigatus

(2015) D. A. Argunov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemical Synthesis of the Repeating Unit of Type Ia Group B Streptococcus Capsular Polysaccharide

(2015) Prolay K. Mondal et al.   ORGANIC LETTERS

Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity

(2015) Pratap S. Patil et al.   Nature Communications

A Synthetic Disaccharide Analogue from Neisseria meningitidis A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated

(2015) Silvia Fallarini et al.   ACS Infectious Diseases

6-O-Branched Oligo-β-glucan-Based Antifungal Glycoconjugate Vaccines

(2015) Guochao Liao et al.   ACS Infectious Diseases

Health and Economic Outcomes of Introducing the New MenB Vaccine (Bexsero) into the Italian Routine Infant Immunisation Programme

(2015) Marcello Tirani et al.   PLoS One

Synthesis and immunological evaluation of protein conjugates ofNeisseria meningitidisX capsular polysaccharide fragments

(2014) Laura Morelli et al.   Beilstein Journal of Organic Chemistry

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

(2014) Nina M. van Sorge et al.   Cell Host & Microbe

Synthesis of a Pentasaccharide and Neoglycoconjugates Related to Fungal α-(1→3)-Glucan and Their Use in the Generation of Antibodies to TraceAspergillus fumigatusCell Wall

(2014) Bozhena S. Komarova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

(2014) M. J. Walker et al.   CLINICAL MICROBIOLOGY REVIEWS

A Strategy for Multivalent Presentation of Carba Analogues fromN. meningitidisA Capsular Polysaccharide

(2014) Daniela Ramella et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Significant structural change in both O- and N-linked carbohydrate moieties of the antigenic galactomannan from Aspergillus fumigatus grown under different culture conditions

(2014) Atsushi Kudoh et al.   GLYCOBIOLOGY

Treatment and prophylaxis of melioidosis

(2014) David Dance   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Virulence Polysaccharide Vi Released by Salmonella Typhi Targets Membrane Prohibitin to Inhibit T-Cell Activation

(2014) Srikanth K. Santhanam et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Recognition of Brucella A and M Antigens Dissected by Synthetic Oligosaccharide Glycoconjugates Leads to a Disaccharide Diagnostic for Brucellosis

(2014) N. Vijaya Ganesh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

(2014) Charles Gauthier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review

(2014) Nishant Jaiswal et al.   PLoS One

Synthesis of conjugation-ready zwitterionic oligosaccharides by chemoselective thioglycoside activation

(2014) B. Schumann et al.   Chemical Science

Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide

(2013) Qi Gao et al.   ACS Chemical Biology

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Synthesis ofNeisseria meningitidisSerogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development

(2013) Chia-Hung Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of a Universal Antigen to Detect Brucellosis

(2013) Julie Guiard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and immunological activity of an oligosaccharide-conjugate as a vaccine candidate against Group A Streptococcus

(2013) France-Isabelle Auzanneau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reinvestigation of the structure of Brucella O-antigens

(2013) Joanna Kubler-Kielb et al.   CARBOHYDRATE RESEARCH

Epitope Mapping of Monoclonal Antibodies using Synthetic Oligosaccharides Uncovers Novel Aspects of Immune Recognition of the Psl Exopolysaccharide ofPseudomonas aeruginosa

(2013) Huiqing Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor

(2013) Felix Wojcik et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conjugation of Polysaccharide 6B from Streptococcus pneumoniae with Pneumococcal Surface Protein A: PspA Conformation and Its Effect on the Immune Response

(2013) Catia T. Perciani et al.   Clinical and Vaccine Immunology

Development of Vi conjugate – a new generation of typhoid vaccine

(2013) Shousun Chen Szu   Expert Review of Vaccines

Immunological Evaluation of a Synthetic Clostridium difficile Oligosaccharide Conjugate Vaccine Candidate and Identification of a Minimal Epitope

(2013) Christopher E. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X

(2013) F. Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetically defined glycoprotein vaccines: current status and future directions

(2013) Roberto Adamo et al.   Chemical Science

Development of Burkholderia mallei and pseudomallei vaccines

(2013) Ediane B. Silva et al.   Frontiers in Cellular and Infection Microbiology

Design of a Candida albicans Disaccharide Conjugate Vaccine by Reverse Engineering a Protective Monoclonal Antibody

(2012) David R. Bundle et al.   ACS Chemical Biology

Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide

(2012) Roberto Adamo et al.   ACS Chemical Biology

Anti-bacterial monoclonal antibodies: Back to the future?

(2012) Martin B. Oleksiewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis and Biological Investigation of PIM Mimics Carrying Biotin or a Fluorescent Label for Cellular Imaging

(2012) Sophie Front et al.   BIOCONJUGATE CHEMISTRY

Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation

(2012) Hiroshi Tanaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Serotype-independent pneumococcal vaccines

(2012) Eliane Namie Miyaji et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immunization strategies forClostridium difficileinfections

(2012) Fabien Rebeaud et al.   Expert Review of Vaccines

The roles of biofilm matrix polysaccharide Psl in mucoidPseudomonas aeruginosabiofilms

(2012) Luyan Ma et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Molecular Recognition ofCandida albicans(1→2)-β-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues

(2012) Margaret A. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The challenges and promises of new therapies for cystic fibrosis: Figure 1.

(2012) Gerald B. Pier   JOURNAL OF EXPERIMENTAL MEDICINE

Surface Coatings Shape the Protein Corona of SPIONs with Relevance to Their Application in Vivo

(2012) Angéla Jedlovszky-Hajdú et al.   LANGMUIR

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles

(2012) Silvia Fallarini et al.   Nanoscale

Synthesis and preliminary biological evaluation of carba analogues from Neisseria meningitidis A capsular polysaccharide

(2012) Qi Gao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A β-mannan trisaccharide conjugate vaccine aids clearance of Candida albicans in immunocompromised rabbits

(2012) Tomasz Lipinski et al.   VACCINE

Characterization of size, structure and purity of serogroup X Neisseria meningitidis polysaccharide, and development of an assay for quantification of human antibodies

(2012) Ouli Xie et al.   VACCINE

Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: A cluster randomized trial in Karachi, Pakistan

(2012) M. Imran Khan et al.   VACCINE

Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids: From Monomers to Dodecamers

(2011) Kuo-Ching Chu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prevnar 13, the New 13-Valent Pneumococcal Conjugate Vaccine

(2011) Allana J Sucher et al.   ANNALS OF PHARMACOTHERAPY

Synthesis of glycoconjugate fragments of mycobacterial phosphatidylinositol mannosides and lipomannan

(2011) Benjamin Cao et al.   Beilstein Journal of Organic Chemistry

A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile Is Antigenic and Immunogenic

(2011) Matthias A. Oberli et al.   CHEMISTRY & BIOLOGY

A Highly α-Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities

(2011) Lin Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clinical Features and Epidemiology of Melioidosis Pneumonia: Results From a 21-Year Study and Review of the Literature

(2011) E. M. Meumann et al.   CLINICAL INFECTIOUS DISEASES

Multidrug-resistant pneumococci (serotype 8) causing invasive disease in HIV+ patients

(2011) J.C. Sanz et al.   CLINICAL MICROBIOLOGY AND INFECTION

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles

(2011) Xilian Bai et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines

(2011) Jan Poolman et al.   Expert Review of Vaccines

Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197Conjugate as Vaccine Candidate againstCandida albicans

(2011) Roberto Adamo et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

(2011) Aarti Agrawal et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Galacturonic Acid Lactones in the Synthesis of All Trisaccharide Repeating Units of the Zwitterionic Polysaccharide Sp1

(2011) Alphert E. Christina et al.   JOURNAL OF ORGANIC CHEMISTRY

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Emergence of Epidemic Neisseria meningitidis Serogroup X Meningitis in Togo and Burkina Faso

(2011) Isabelle Delrieu et al.   PLoS One

Phosphatidylinositol di-mannoside and derivates modulate the immune response to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection

(2011) Natalie A. Parlane et al.   VACCINE

Development of Vaccines Against Burkholderia Pseudomallei

(2011) Natasha Patel et al.   Frontiers in Microbiology

β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1

(2010) Hiroshi Tanaka et al.   CHEMICAL COMMUNICATIONS

Synthesis of Monomeric and Dimeric Repeating Units of the Zwitterionic Type 1 Capsular Polysaccharide fromStreptococcus pneumoniae

(2010) Xiangyang Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Emerging Resistant Gram-Negative Aerobic Bacilli in Hospital-Acquired Infections

(2010) Anjali N. Kunz et al.   CHEMOTHERAPY

Characterization of Gene Use and Efficacy of Mouse Monoclonal Antibodies toStreptococcus pneumoniaeSerotype 8

(2010) Masahide Yano et al.   Clinical and Vaccine Immunology

The Changing Epidemiology of Clostridium difficile Infections

(2010) J. Freeman et al.   CLINICAL MICROBIOLOGY REVIEWS

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol

(2010) Pratap S. Patil et al.   ORGANIC LETTERS

First Synthesis ofC. difficilePS-II Cell Wall Polysaccharide Repeating Unit

(2010) Elisa Danieli et al.   ORGANIC LETTERS

Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate

(2010) Anna Kabanova et al.   VACCINE

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

(2010) Carla Bromuro et al.   VACCINE

Vi-CRM197 as a new conjugate vaccine against Salmonella Typhi

(2010) F. Micoli et al.   VACCINE

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

Chemistry and Biology of Galactofuranose-Containing Polysaccharides

(2009) Michele R. Richards et al.   CHEMBIOCHEM

Increasing Burden of Invasive Group B Streptococcal Disease in Nonpregnant Adults, 1990–2007

(2009) Tami H. Skoff et al.   CLINICAL INFECTIOUS DISEASES

Inactivated and subunit vaccines to prevent shigellosis

(2009) Robert W Kaminski et al.   Expert Review of Vaccines

Pseudomonas aeruginosa: a formidable and ever-present adversary

(2009) K.G. Kerr et al.   JOURNAL OF HOSPITAL INFECTION

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: England and Wales, 1996–2006

(2009) Caroline L. Trotter et al.   JOURNAL OF INFECTION

Modeling of synthetic phosphono and carba analogues of N-acetyl-α-d-mannosamine 1-phosphate, the repeating unit of the capsular polysaccharide from Neisseria meningitidis serovar A

(2009) Lucio Toma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide

(2009) Laura Legnani et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Principles, Techniques, and Applications of T2*-based MR Imaging and Its Special Applications

(2009) Govind B. Chavhan et al.   RADIOGRAPHICS

Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

(2009) Asif Ali et al.   TETRAHEDRON LETTERS

Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics

(2009) Jan Poolman et al.   VACCINE

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

(2009) Luyan Ma et al.   PLoS Pathogens

Multivalent, Saccharide-Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type ANeisseria meningitidisAntigens

(2008) Flavio Manea et al.   ADVANCED MATERIALS

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

(2008) Daniele Castagnolo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of monodeoxy and mono-O-methyl congeners of methyl β-d-mannopyranosyl-(1→2)-β-d-mannopyranoside for epitope mapping of anti-Candida albicans antibodies

(2008) Corwin M. Nycholat et al.   CARBOHYDRATE RESEARCH

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Chemical Synthesis of All Phosphatidylinositol Mannoside (PIM) Glycans fromMycobacterium tuberculosis

(2008) Siwarutt Boonyarattanakalin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors of UDP-Galactopyranose Mutase Thwart Mycobacterial Growth

(2008) Emily C. Dykhuizen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrated model of the recognition of Candida albicans by the innate immune system

(2007) Mihai G. Netea et al.   NATURE REVIEWS MICROBIOLOGY