Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

Propargylamine Containing Compounds as Modulators of Proteolytic Cleavage of Amyloid Protein Precursor: Involvement of MAPK and PKC Activation

(2017) Orit Bar-Am et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs

(2012) Jacques Joubert et al.   ChemMedChem

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species

(2012) Xiaoming He et al.   DALTON TRANSACTIONS

Ironing out tau's role in parkinsonism

(2012) Jeannette N Stankowski et al.   NATURE MEDICINE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Protein–RNA interactions: new genomic technologies and perspectives

(2012) Julian König et al.   NATURE REVIEWS GENETICS

Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake

(2012) Ling Xie et al.   NEUROCHEMISTRY INTERNATIONAL

Caffeine for treatment of Parkinson disease: A randomized controlled trial

(2012) R. B. Postuma et al.   NEUROLOGY

Industrial toxicants and Parkinson's disease

(2012) W. Michael Caudle et al.   NEUROTOXICOLOGY

Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease

(2012) C. Laloux et al.   PHARMACOLOGICAL RESEARCH

Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

(2011) Alaina S. DeToma et al.   CHEMBIOCHEM

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Natural Products of Dietary Origin as Lead Compounds in Virtual Screening and Drug Design

(2011) Werner J. Geldenhuys et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Emerging adenosine receptor agonists – an update

(2011) Zhan-Guo Gao et al.   EXPERT OPINION ON EMERGING DRUGS

Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species

(2011) Joseph J. Braymer et al.   INORGANIC CHEMISTRY

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

(2011) Thomas Mendgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The emergence of designed multiple ligands for neurodegenerative disorders

(2011) Werner J. Geldenhuys et al.   PROGRESS IN NEUROBIOLOGY

Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors

(2011) Werner J. Geldenhuys et al.   MedChemComm

Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Antidiabetes Drugs

(2011) Claudia Binda et al.   ACS Medicinal Chemistry Letters

Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening

(2010) Werner J. Geldenhuys et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyamine Conjugation of Curcumin Analogues toward the Discovery of Mitochondria-Directed Neuroprotective Agents†

(2010) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Administration of thiazolidinediones for neuroprotection in ischemic stroke: a pre-clinical systematic review

(2010) Amanda T. White et al.   JOURNAL OF NEUROCHEMISTRY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

R-Deprenyl: Pharmacological Spectrum of its Activity

(2010) K. Magyar et al.   NEUROCHEMICAL RESEARCH

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

Structure–activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action

(2009) Maria Laura Bolognesi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: Synthesis, in vitro binding, and molecular modeling

(2009) Samuel D. Banister et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alzheimer's disease: new approaches to drug discovery

(2009) Maria L Bolognesi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

MTDL Design Strategy in the Context of Alzheimers Disease: From Lipocrine to Memoquin and Beyond

(2009) M. Bolognesi et al.   CURRENT PHARMACEUTICAL DESIGN

Designing Multiple Ligands – Medicinal Chemistry Strategies and Challenges

(2009) Richard Morphy et al.   CURRENT PHARMACEUTICAL DESIGN

Inhaled corticosteroids as combination therapy with β-adrenergic agonists in airways disease: present and future

(2009) Kian Fan Chung et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease

(2009) Francesca Mancini et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease

(2008) Pramod Kumar et al.   BEHAVIOURAL BRAIN RESEARCH

Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues

(2008) Judey Pretorius et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The PPARγ agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B

(2008) L P Quinn et al.   BRITISH JOURNAL OF PHARMACOLOGY

The neuroprotective mechanism of action of the multimodal drug ladostigil

(2008) Orly Weinreb   Frontiers in Bioscience-Landmark

Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging

(2008) Kwok-Tung Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

(2008) Roberta Montanari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease

(2008) Maria Laura Bolognesi et al.   Neurotherapeutics

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

(2008) Julie Blanchet et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acteylcholinesterase inhibitor rivastigmine enhances cellular defenses in neuronal and macrophage-like cell lines

(2008) Ximing Zhou et al.   Translational Research