The ABP Dendrimer, a Drug-Candidate against Inflammatory Diseases That Triggers the Activation of Interleukin-10 Producing Immune Cells

Recent progress in dendrimer-based nanomedicine development

(2018) Yejin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Three-Dimensional Directionality Is a Pivotal Structural Feature for the Bioactivity of Azabisphosphonate-Capped Poly(PhosphorHydrazone) Nanodrug Dendrimers

(2018) Myriam Hayder et al.   BIOMACROMOLECULES

Immune regulation by monocytes

(2018) Peter J. Murray   SEMINARS IN IMMUNOLOGY

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

(2017) Alexandra Zanin-Zhorov et al.   JOURNAL OF IMMUNOLOGY

Engineering Natural Killer Cells for Cancer Immunotherapy

(2017) Katayoun Rezvani et al.   MOLECULAR THERAPY

Pro-Inflammatory Versus Anti-Inflammatory Effects of Dendrimers: The Two Faces of Immuno-Modulatory Nanoparticles

(2017) Séverine Fruchon et al.   Nanomaterials

Safety and Therapeutic Potential of M2 Macrophages in Stroke Treatment

(2016) Elena R. Chernykh et al.   CELL TRANSPLANTATION

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

(2016) Jens Geginat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Success and failure of biological treatment in systemic lupus erythematosus: A critical analysis

(2016) Mariele Gatto et al.   JOURNAL OF AUTOIMMUNITY

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

(2016) Aung Naing et al.   JOURNAL OF CLINICAL ONCOLOGY

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Poly(phosphorhydrazone) dendrimers: yin and yang of monocyte activation for human NK cell amplification applied to immunotherapy against multiple myeloma

(2016) Mary Poupot et al.   Nanomedicine-Nanotechnology Biology and Medicine

Influence of PPH dendrimers' surface functions on the activation of human monocytes: a study of their interactions with pure lipid model systems

(2016) F. Ielasi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Phosphorus-Based Dendrimer ABP Treats Neuroinflammation by Promoting IL-10-Producing CD4+ T Cells

(2015) Myriam Hayder et al.   BIOMACROMOLECULES

The dendrimer paradox – high medical expectations but poor clinical translation

(2015) Sonke Svenson   CHEMICAL SOCIETY REVIEWS

Subconjunctival Injection of XG-102, a c-Jun N-Terminal Kinase Inhibitor Peptide, in the Treatment of Endotoxin-Induced Uveitis in Rats

(2015) Ikram El Zaoui et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Interaction studies reveal specific recognition of an anti-inflammatory polyphosphorhydrazone dendrimer by human monocytes

(2015) Jérémy Ledall et al.   Nanoscale

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The key role of the scaffold on the efficiency of dendrimer nanodrugs

(2015) Anne-Marie Caminade et al.   Nature Communications

Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

(2014) Yin Tang et al.   BIOMACROMOLECULES

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

(2014) Avraham Ben-Nun et al.   JOURNAL OF AUTOIMMUNITY

Repeated intravenous injections in non-human primates demonstrate preclinical safety of an anti-inflammatory phosphorus-based dendrimer

(2014) Séverine Fruchon et al.   Nanotoxicology

Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent

(2014) Yannick Degboé et al.   ARTHRITIS RESEARCH & THERAPY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

An Azabisphosphonate-Capped Poly(phosphorhydrazone) Dendrimer for the Treatment of Endotoxin-Induced Uveitis

(2013) Séverine Fruchon et al.   MOLECULES

Frequency and route of administration in the treatment of experimental arthritis by phosphorus-based dendrimer

(2012) Myriam Hayder et al.   ANNALS OF THE RHEUMATIC DISEASES

Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers

(2012) Ian Teo et al.   EMBO Molecular Medicine

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

Dendrimers To Treat Rheumatoid Arthritis

(2011) Xavier Bosch   ACS Nano

Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)

(2011) Ian McGowan et al.   AIDS

The gene expression profile of phosphoantigen-specific humanγδT lymphocytes is a blend of αβ T-cell and NK-cell signatures

(2011) Fréderic Pont et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendrimer drug mends monocytes

(2011) Emma Leah   Nature Reviews Rheumatology

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

Anti-Inflammatory Properties of Dendrimersper se

(2011) Myriam Hayder et al.   TheScientificWorldJOURNAL

Dendrimers ended by non-symmetrical azadiphosphonate groups: Synthesis and immunological properties

(2009) Patrice Marchand et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pitfalls on the roadmap to γδ T cell-based cancer immunotherapies

(2009) Ludovic Martinet et al.   IMMUNOLOGY LETTERS

Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy

(2009) Damien Portevin et al.   Journal of Translational Medicine

Efficient synthesis of phosphorus-containing dendrimers capped with isosteric functions of amino-bismethylene phosphonic acids

(2009) Olivier Rolland et al.   TETRAHEDRON LETTERS

Tailored Control and Optimisation of the Number of Phosphonic Acid Termini on Phosphorus-Containing Dendrimers for the Ex-Vivo Activation of Human Monocytes

(2008) Olivier Rolland et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trogocytosis and killing of IL-4-polarized monocytes by autologous NK cells

(2008) Mary Poupot et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anti-inflammatory and immunosuppressive activation of human monocytes by a bioactive dendrimer

(2008) Séverine Fruchon et al.   JOURNAL OF LEUKOCYTE BIOLOGY