Article
Nanoscience & Nanotechnology
JingWen Huang, XiaoTing Jian, MengMeng Xu, Han Wang, ZhaoHong Liao, HaiQiang Lan, LinGe Wang, JiJie Hu, QianQian Yu, Hua Liao
Summary: Carbon-based nanomaterials, with their specific surface area and controlled structures, can modulate immune responses in vivo.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Review
Engineering, Biomedical
Zimeng Zhai, Yiyun Cheng, Jiaxu Hong
Summary: Glaucoma, the leading cause of irreversible blindness worldwide, requires long-term management with drugs, but there is a shortage of effective antiglaucoma drugs due to biological barriers of the human eyes. Nanomedicines have emerged as promising alternatives to conventional ophthalmic formulations, offering improved drug delivery and potential for neuroprotective treatment of damaged nerves in glaucoma.
ACTA BIOMATERIALIA
(2021)
Review
Cardiac & Cardiovascular Systems
Edoardo Bertero, Jan Dudek, Clement Cochain, Murilo Delgobo, Gustavo Ramos, Brenda Gerull, Takahiro Higuchi, Martin Vaeth, Alma Zernecke, Stefan Frantz, Ulrich Hofmann, Christoph Maack
Summary: The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of cardiovascular diseases. This paper provides an overview of the interrelation between inflammation and metabolism, discusses the involvement of disrupted immuno-metabolic interface in cardiovascular disease, and presents new technologies and therapeutic approaches.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Changren Liu, Ruonan Wang, Ying Sun, Changfeng Yin, Zhewei Gu, Wei Wu, Xiqun Jiang
Summary: This study presents a new strategy for synthesizing scaffold-modifiable dendrons via orthogonal amino protection and solid-phase synthesis method. The dendrons exhibit super selectivity, high reactivity, and wide applicability to various reaction types, making them an ideal choice for site-specific bifunctionalization. The dendron-based prodrug, conjugated with doxorubicin (DOX) and phenylboronic acid (PBA) groups, shows extraordinary antitumor efficacy and can eradicate tumors established in mice. This work provides a practical strategy for synthesizing scaffold-modifiable dendrons and offers a promising nanoplatform for function integration in a precisely controlled manner.
ACS CENTRAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Protap Biswas, Abhishek Dutta, Parthasarathi Dastidar
Summary: A series of metallogelators designed based on structural rationale showed anticancer and antibacterial activities, indicating the potential importance of developing a self-drug-delivery system.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Judit Morla-Folch, Guillem Vargas-Nadal, Edgar Fuentes, Silvia Illa-Tuset, Mariana Koeber, Cristina Sissa, Silvia Pujals, Anna Painelli, Jaume Veciana, Jordi Faraudo, Kevin D. Belfield, Lorenzo Albertazzi, Nora Ventosa
Summary: The development of bright fluorescent nanoparticles is essential for improving the resolution and signal-to-noise ratio in fluorescence imaging techniques. In this study, we developed FRET-based nanovesicles with different dye loadings and investigated their optical properties at the nanoscopic level. The results show that the dye's molecular diffusion in fluid-like membranes can modulate the optical properties of the nanoparticles, resulting in highly efficient and stable nanoprobes.
CHEMISTRY OF MATERIALS
(2022)
Review
Medicine, General & Internal
Katarzyna Tomaszewska, Aleksandra Slodka, Bartlomiej Tarkowski, Anna Zalewska-Janowska
Summary: Urticaria is a condition characterized by itchy wheals and angioedema. The pathophysiology of chronic spontaneous urticaria (CSU) is not well understood, but there are immunological and non-immunological abnormalities that result in clinical symptoms. Latest hypotheses suggest that Mast cells (MCs) activated by autoantibodies mediate the vasoactive and neurospecific effect in CSU. Psychological stress is seen as a triggering and modulating factor in CSU, but the mechanistic background is not fully elucidated. This review highlights the neuro-immuno-psychological aspects of CSU, suggesting the use of psychological tools and non-invasive interventions to reduce psychological stress.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mkhuseli Zenze, Aliscia Daniels, Moganavelli Singh
Summary: The formulation of nanoscale systems with well-defined sizes and shapes is important for various applications, including drug and gene delivery. Dendrimers have unique characteristics that make them suitable for modifying nanoparticles for biomedical purposes. They can incorporate multiple drugs or genes and can be easily modified for targeted delivery. In this review, the properties of dendrimers and their use as modifiers of inorganic nanoparticles for enhanced therapeutic delivery are discussed.
Article
Biochemistry & Molecular Biology
Maria Perticone, Raffaele Maio, Simona Gigliotti, Franco Arturi, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Francesco Perticone
Summary: Inflammation plays a key role in atherosclerosis, and individuals with high 1-hour post-load plasma glucose have an increased risk of diabetes and target organ damage. This study aimed to investigate the differences in immune-mediated inflammatory parameters in newly-diagnosed hypertensive patients with or without 1-hour post-load hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Spectroscopy
Linus Pauling F. Peixoto, Jacqueline F. L. Santos, Gustavo F. S. Andrade
Summary: In this study, a simple and fast analysis of albumin antibody was achieved using an immuno-biosensor based on gold nanorods and surface-enhanced fluorescence. The results demonstrated the efficiency and specificity of the biosensor, with the signal intensity in the presence of anti-BSA being three times stronger compared to the absence of analyte.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Immunology
Sophie Van Linthout, Hans-Dieter Volk
Summary: This review discusses the immunological aspects connecting cancer and cardiovascular disease, and the opportunities and challenges of integrating immunotherapies and anti-inflammatory therapies in both diseases. It also discusses the use of advanced therapies like chimeric antigen receptor T cells to address the burden of cancer and cardiovascular disease. The review emphasizes the importance of using biomarkers to guide therapeutic interventions in cardiology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Kongwei Li, Kaiyue Li, Yuan He, Shan Liang, Xiaorong Shui, Wei Lei
Summary: Cardiovascular disease is the leading cause of death worldwide, with atherosclerosis being a major contributor. AhR plays an important role in atherosclerosis by regulating immuno-inflammatory responses and metabolism pathways, potentially serving as a target for controlling the disease through precise interventions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Allergy
Cristobalina Mayorga, Ezequiel Perez-Inestrosa, Javier Rojo, Marta Ferrer, Maria Isabel Montanez
Summary: Nanotechnology, conducted at the nanoscale, has led to the development of nanomaterials with wide applications in biomedicine, while facing challenges such as toxicity and hypersensitivity responses that require evaluation and resolution. The application of nanoengineered materials in allergy diagnosis and specific immunotherapy shows promising prospects for improving sensitivity and efficacy.
Article
Immunology
Pavanish Kumar, Amanda Lim, Su Li Poh, Sharifah Nur Hazirah, Camillus Jian Hui Chua, Nursyuhadah Binte Sutamam, Thaschawee Arkachaisri, Joo Guan Yeo, Theo Kofidis, Vitaly Sorokin, Carolyn S. P. Lam, Arthur Mark Richards, Salvatore Albani
Summary: This study used mass cytometry and a data-driven systems immunology approach to analyze the immune system in patients with chronic heart failure (HF). The results showed expansion of cytotoxic and inflammatory immune cell subsets in HF patients, as well as changes in the immune cell network structure. Additionally, specific immune mechanisms were found in HF patients with preserved ejection fraction, including an increase in inflammatory MAIT and CD4 T cell subsets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sejal Chauhan, Raghu Solanki, Ashok Kumar Jangid, Poonam Jain, Pranjali Pranjali, Sunita Patel, Anupam Guleria, Deep Pooja, Hitesh Kulhari
Summary: Enzyme responsive nanocarriers have the advantages of low toxicity, targeted delivery, and high therapeutic efficiency. In this study, a MMP9 enzyme responsive manganese nanocarrier was developed for site-specific delivery of anticancer drugs. The nanocarrier exhibited high encapsulation efficiency and controlled release, and showed superior anticancer activity against HCT116 human colon cancer cells compared to free drugs. It also demonstrated potential application in diagnosis through magnetic resonance imaging.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Severine Fruchon, Remy Poupot
Review
Chemistry, Physical
Remy Poupot, Dylan Bergozza, Severine Fruchon
Article
Biochemistry & Molecular Biology
Severine Fruchon, Elisabeth Bellard, Nicolas Beton, Cecile Goursat, Abdelouand Oukhrib, Anne-Marie Caminade, Muriel Blanzat, Cedric-Olivier Turrin, Muriel Golzio, Remy Poupot
Article
Biochemistry & Molecular Biology
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Muriel Blanzat, Cedric-Olivier Turrin, Anne-Marie Caminade, Eric Lacoste, Severine Fruchon, Remy Poupot
Review
Pharmacology & Pharmacy
Ranime Jebbawi, Severine Fruchon, Cedric-Olivier Turrin, Muriel Blanzat, Remy Poupot
Review
Biochemistry & Molecular Biology
Yannick Degboe, Remy Poupot, Mary Poupot
Summary: Monocytes and macrophages play a crucial role in the immune system, detecting and eradicating danger signals while maintaining tissue homeostasis. Imbalance in their response can lead to pathological disorders, and repolarization of these unbalanced macrophages shows promise as a therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)