In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts

(2017) Sabrina Fechtner et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-Cancer Effects of Green Tea by Either Anti- or Pro-Oxidative Mechanisms

(2016) Sumio Hayakawa et al.   Asian Pacific Journal of Cancer Prevention

Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis

(2016) Jaganmay Sarkar et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of pro-/active MMP-2 by green tea catechins and prediction of their interaction by molecular docking studies

(2016) Animesh Chowdhury et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cancer Preventive Activities of Tea Catechins

(2016) Chung Yang et al.   MOLECULES

Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity

(2016) Takuji Suzuki et al.   MOLECULES

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

(2016) Jianglin Zhang et al.   Oncotarget

Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein

(2016) Nurul Azira Ismail et al.   Interdisciplinary Sciences-Computational Life Sciences

Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6

(2016) Anil K. Singh et al.   Arthritis & Rheumatology

Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds

(2016) Patrick Cherubin et al.   PLoS One

The Heat Shock Protein 90 Inhibitor, (-)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

(2015) M. A. Moses et al.   Cancer Prevention Research

Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma

(2015) Rituparna Bhattacharjee et al.   JOURNAL OF MOLECULAR MODELING

Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro

(2015) Pushpendra Singh et al.   MEDICAL ONCOLOGY

Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis

(2015) Christina W. A. Moyle et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of body weight reduction and metabolic syndrome alleviation by tea

(2015) Chung S. Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

(−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

(2015) MUNAWWAR ALI KHAN et al.   ONCOLOGY REPORTS

Anchor-based classification and type-C inhibitors for tyrosine kinases

(2015) Kai-Cheng Hsu et al.   Scientific Reports

Investigate the Binding of Catechins to Trypsin Using Docking and Molecular Dynamics Simulation

(2015) Fengchao Cui et al.   PLoS One

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

(2014) Jordi Rodon et al.   CLINICAL CANCER RESEARCH

Identifying a C-terminal ATP binding sites-based novel Hsp90-Inhibitor in silico: A plausible therapeutic approach in Alzheimer’s disease

(2014) Shumaila Khalid et al.   MEDICAL HYPOTHESES

Epigallocatechin gallate prevents inflammation by reducing macrophage infiltration and inhibiting tumor necrosis factor-α signaling in the pancreas of rats on a high-fat diet

(2014) Yanli Cao et al.   NUTRITION RESEARCH

Green Tea and One of Its Constituents, Epigallocatechine-3-gallate, Are Potent Inhibitors of Human 11β-hydroxysteroid Dehydrogenase Type 1

(2014) Jan Hintzpeter et al.   PLoS One

Inhibition of Catalase by Tea Catechins in Free and Cellular State: A Biophysical Approach

(2014) Sandip Pal et al.   PLoS One

Molecular Interactions between (−)-Epigallocatechin Gallate Analogs and Pancreatic Lipase

(2014) Shihui Wang et al.   PLoS One

Binding interaction between (−)-epigallocatechin gallate causes impaired spreading of cancer cells on fibrinogen

(2013) Yasuo SUZUKI et al.   BIOMEDICAL RESEARCH-TOKYO

Direct interaction of natural and synthetic catechins with signal transducer activator of transcription 1 affects both its phosphorylation and activity

(2013) Marta Menegazzi et al.   FEBS Journal

Characterization of Binding Interactions of (−)-Epigallocatechin-3-gallate from Green Tea and Lipase

(2013) Xuli Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Design and Synthesis of Dual-Action Inhibitors Targeting Histone Deacetylases and 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase for Cancer Treatment

(2013) Jhih-Bin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of the inhibition of the STAT3 signaling pathway by EGCG

(2013) YANG WANG et al.   ONCOLOGY REPORTS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Molecular Simulations in the Development of Inhibitors of Amyloid β-Peptide Aggregation for the Treatment of Alzheimer’s Disease

(2012) Justin A. Lemkul et al.   ACS Chemical Neuroscience

Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells

(2012) Shuntaro Tsukamoto et al.   BIOCHEMICAL JOURNAL

Inhibitory Mechanism of Pancreatic Amyloid Fibril Formation: Formation of the Complex between Tea Catechins and the Fragment of Residues 22–27

(2012) Miya Kamihira-Ishijima et al.   BIOCHEMISTRY

Green tea catechins can bind and modify ERp57/PDIA3 activity

(2012) Lucie Trnková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The green tea polyphenol (−)-epigallocatechin gallate precipitates salivary proteins including alpha-amylase: biochemical implications for oral health

(2012) Kumiko Hara et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Epigallocatechin-3-gallate and penta-O-galloyl-β-d-glucose inhibit protein phosphatase-1

(2012) Andrea Kiss et al.   FEBS Journal

Structures of Aβ17–42 Trimers in Isolation and with Five Small-Molecule Drugs Using a Hierarchical Computational Procedure

(2012) Yassmine Chebaro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Green Tea Polyphenol EGCG Sensing Motif on the 67-kDa Laminin Receptor

(2012) Yoshinori Fujimura et al.   PLoS One

Health-promoting effects of green tea

(2012) Yasuo SUZUKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Acute neurocognitive effects of epigallocatechin gallate (EGCG)

(2011) Andrew Scholey et al.   APPETITE

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

(2011) Glenn S. Van Aller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

(2011) D. V. Urusova et al.   Cancer Prevention Research

(−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68

(2011) Tomoko Tanaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Comparative Reverse Docking Strategy to Identify Potential Antineoplastic Targets of Tea Functional Components and Binding Mode

(2011) Rong Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site

(2011) Changhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Epigallocatechin-3-Gallate Reduces Airway Inflammation in Mice through Binding to Proinflammatory Chemokines and Inhibiting Inflammatory Cell Recruitment

(2011) S. Qin et al.   JOURNAL OF IMMUNOLOGY

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

(2011) Massimiliano Cuccioloni et al.   JOURNAL OF LIPID RESEARCH

Influence of the Galloyl Moiety in Tea Catechins on Binding Affinity for Human Serum Albumin

(2011) Kanako MINODA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Tea catechins and their applications as supplements and pharmaceutics

(2011) Yukihiko Hara   PHARMACOLOGICAL RESEARCH

Green tea polyphenol sensing

(2011) Hirofumi TACHIBANA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The Crystal Structure of the Green Tea Polyphenol (−)-Epigallocatechin Gallate−Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site,

(2010) Masanori Miyata et al.   BIOCHEMISTRY

Biological actions of green tea catechins on cardiac troponin C

(2010) Naoto Tadano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigallocatechin Gallate Suppresses Lung Cancer Cell Growth through Ras-GTPase-Activating Protein SH3 Domain-Binding Protein 1

(2010) J. H. Shim et al.   Cancer Prevention Research

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase

(2009) Luís Sánchez-del-Campo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase

(2008) Jung-Hyun Shim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fyn is a novel target of (−)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation

(2007) Zhiwei He et al.   MOLECULAR CARCINOGENESIS