Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Pathophysiology of Migraine: A Disorder of Sensory Processing

(2017) Peter J. Goadsby et al.   PHYSIOLOGICAL REVIEWS

A nontoxic pain killer designed by modeling of pathological receptor conformations

(2017) V. Spahn et al.   SCIENCE

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time

(2017) Dimitry Ofengeim et al.   TRENDS IN MOLECULAR MEDICINE

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

(2017) Chun-Hua Liu et al.   Nature Communications

A new target for G protein signaling

(2017) László Csanády   eLife

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

(2017) Sara González-Rodríguez et al.   eLife

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

(2017) Talisia Quallo et al.   eLife

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

(2017) Doreen Badheka et al.   eLife

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing

(2017) Minh Q. Nguyen et al.   PLoS One

Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P

(2016) Dongyang Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Gaq proteins: molecular pharmacology and therapeutic potential

(2016) Danielle Kamato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

(2016) Hu Zhu et al.   GENESIS

Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function

(2016) A. A. Pradhan et al.   JOURNAL OF NEUROSCIENCE

Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons

(2016) Jami L. Saloman et al.   JOURNAL OF NEUROSCIENCE

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms

(2016) Fang Qiu et al.   NEUROCHEMICAL RESEARCH

Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic

(2016) Phil Skolnick et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca 2+ -activated chloride channels

(2016) Isabella Salzer et al.   NEUROPHARMACOLOGY

Adenosine receptor targets for pain

(2016) J. Sawynok   NEUROSCIENCE

Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

(2016) Steve Davidson et al.   PAIN

Gi-protein–coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming

(2016) Dioneia Araldi et al.   PAIN

Spotlight on pain

(2016) Bryan A. Copits et al.   PAIN

Nociceptin/orphanin FQ receptor expression in clinical pain disorders and functional effects in cultured neurons

(2016) Praveen Anand et al.   PAIN

Adenosine-A1 receptor agonist induced hyperalgesic priming type II

(2016) Dioneia Araldi et al.   PAIN

Optogenetic and chemogenetic strategies for sustained inhibition of pain

(2016) Shrivats M. Iyer et al.   Scientific Reports

Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons

(2016) Ganlu Hu et al.   Scientific Reports

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

(2015) Xin Chen et al.   ACS Chemical Neuroscience

GABAB receptors inhibit low-voltage activated and high-voltage activated Ca2+ channels in sensory neurons via distinct mechanisms

(2015) Dongyang Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

(2015) Christina Hanack et al.   CELL

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

(2015) Chang-Lin Li et al.   CELL RESEARCH

Gαi/o-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later

(2015) Tarsis F. Brust et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization

(2015) Akihiko Ozawa et al.   JOURNAL OF NEUROSCIENCE

Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain

(2015) D. Araldi et al.   JOURNAL OF NEUROSCIENCE

Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release

(2015) Katharina Held et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function

(2015) Amaury François et al.   Cell Reports

Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons

(2014) Louise Gorham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Signatures of Mouse TRPV1-Lineage Neurons Revealed by RNA-Seq Transcriptome Analysis

(2014) Samridhi C. Goswami et al.   JOURNAL OF PAIN

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain

(2014) Yu Shin Kim et al.   NEURON

Somatostatin 4 receptor activation modulates TPRV1 currents in dorsal root ganglion neurons

(2014) Louise Gorham et al.   NEUROSCIENCE LETTERS

Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: Potential roles in acute inflammatory pain

(2014) Mathias Leinders et al.   PAIN

Calcium-Permeable Ion Channels in Pain Signaling

(2014) Emmanuel Bourinet et al.   PHYSIOLOGICAL REVIEWS

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The functional and anatomical dissection of somatosensory subpopulations using mouse genetics

(2014) Claire E. Le Pichon et al.   Frontiers in Neuroanatomy

Defining the nociceptor transcriptome

(2014) Matthew Thakur et al.   Frontiers in Molecular Neuroscience

The K+channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

(2013) Dinah Nockemann et al.   EMBO Molecular Medicine

Design and functional evaluation of an optically active μ-opioid receptor

(2013) Philip A. Barish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An Unusual Cause of Flaccid Paralysis and Coma

(2013) Elena Caron et al.   JOURNAL OF CHILD NEUROLOGY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse

(2013) K.E. Rose et al.   NEUROSCIENCE

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

(2013) Nitish Mittal et al.   Cell Reports

A finer tuning of G-protein signaling through regulated control of RGS proteins

(2012) Jacob Kach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuropeptide Y is analgesic in rats after plantar incision

(2012) Suraj M. Yalamuri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons

(2012) Miles Steven Evans et al.   HEADACHE

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors

(2012) R.M. Govea et al.   NEUROSCIENCE

Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons

(2012) Jian-You Li et al.   NEUROSCIENCE LETTERS

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

(2012) Gábor Pethő et al.   PHYSIOLOGICAL REVIEWS

Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons

(2012) J. E. Linley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dorsal root ganglion – a potential new therapeutic target for neuropathic pain

(2012) Damir Sapunar et al.   Journal of Pain Research

The blood-spinal cord barrier: Morphology and Clinical Implications

(2011) Viktor Bartanusz et al.   ANNALS OF NEUROLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of the Function of TRPV1-Expressing Nociceptive Sensory Neurons by Somatostatin 4 Receptor Agonism: echanism and Therapeutical Implications

(2011) Janos Szolcsanyi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Serotonin Receptor 5-HT2B Mediates Serotonin-Induced Mechanical Hyperalgesia

(2011) S.-Y. Lin et al.   JOURNAL OF NEUROSCIENCE

The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a G  -Dependent Mechanism

(2011) M. Belkouch et al.   JOURNAL OF NEUROSCIENCE

Group II/III Metabotropic Glutamate Receptors Exert Endogenous Activity-Dependent Modulation of TRPV1 Receptors on Peripheral Nociceptors

(2011) S. M. Carlton et al.   JOURNAL OF NEUROSCIENCE

Loperamide

(2011) Claud Regnard et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation

(2011) Shao-Qiu He et al.   NEURON

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors

(2011) Dayna R. Loyd et al.   PAIN

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

(2011) M. Julio-Pieper et al.   PHARMACOLOGICAL REVIEWS

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

An antinociceptive role for substance P in acid-induced chronic muscle pain

(2011) C.-C. J. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels

(2010) Boyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain

(2010) Harry Klimis et al.   PAIN

Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

(2010) John E. Linley et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Coexpression of  - and  -opioid receptors in nociceptive sensory neurons

(2010) H.-B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration

(2010) A. Gupta et al.   Science Signaling

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

(2009) Grégory Scherrer et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

In Search of Analgesia: Emerging Poles of GPCRs in Pain

(2009) L. S. Stone et al.   MOLECULAR INTERVENTIONS

PKC∊-Dependent Potentiation of TTX-Resistant NaV1.8 Current by Neurokinin-1 Receptor Activation in Rat Dorsal Root Ganglion Neurons

(2009) Chun-Lei Cang et al.   Molecular Pain

Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice

(2009) Z. Helyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON