Gaq proteins: molecular pharmacology and therapeutic potential

G-protein inhibition profile of the reported G q/11 inhibitor UBO-QIC

(2016) Jyrki P. Kukkonen   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin

(2016) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling

(2016) PJ Little et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes

(2016) Danielle Kamato et al.   CELLULAR SIGNALLING

New paradigms in GPCR drug discovery

(2015) Kenneth A. Jacobson   BIOCHEMICAL PHARMACOLOGY

Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor

(2015) Harveen Kaur et al.   ORGANIC LETTERS

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog

(2015) Derek T. Rensing et al.   ORGANIC LETTERS

Characterization of UBO-QIC as a Gαqinhibitor in platelets

(2015) Vaishali Inamdar et al.   PLATELETS

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channelsin vitroand painin vivo

(2014) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

(2014) Danielle Kamato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biased Signaling of Protease-Activated Receptors

(2014) Peishen Zhao et al.   Frontiers in Endocrinology

Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation

(2013) Danielle Kamato et al.   CELLULAR SIGNALLING

Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells

(2013) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways

(2013) Peter J. Little   LIFE SCIENCES

ModBase, a database of annotated comparative protein structure models and associated resources

(2013) Ursula Pieper et al.   NUCLEIC ACIDS RESEARCH

Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes

(2012) Sara Pahlavan et al.   CARDIOVASCULAR RESEARCH

G protein coupled receptor transactivation: Extending the paradigm to include serine/threonine kinase receptors

(2012) Micah L. Burch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery

(2012) Kazumasa Zaima et al.   Journal of Natural Medicines

Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury

(2012) Saghir Akhtar et al.   PLoS One

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

(2011) Peter J. Little et al.   PHARMACOLOGY & THERAPEUTICS

VeryGene: linking tissue-specific genes to diseases, drugs, and beyond for knowledge discovery

(2011) Xiaoqin Yang et al.   PHYSIOLOGICAL GENOMICS

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

(2010) Micah L. Burch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor

(2010) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelin-1 Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle is Mediated by Endothelin Receptor Transactivation of the Transforming Growth Factor-β Type I Receptor

(2010) Peter J Little et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions and Regulatory Mechanisms of Gq-Signaling Pathways

(2009) Norikazu Mizuno et al.   NEUROSIGNALS

Comparative Analysis of GPCR Crystal Structures

(2009) David T. Lodowski et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

TiGER: a database for tissue-specific gene expression and regulation

(2008) Xiong Liu et al.   BMC BIOINFORMATICS

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

New Strategies in Drug Discovery for GPCRs: High Throughput Detection of Cellular ERK Phosphorylation

(2008) Michael Crouch et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

(2008) Peter J Little et al.   CURRENT OPINION IN LIPIDOLOGY

Regulation of G protein-coupled receptor signalling: Focus on the cardiovascular system and regulator of G protein signalling proteins

(2008) Mariëlle C. Hendriks-Balk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Coupling mode of receptors and G proteins

(2008) Peter Hein et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY