Review
Chemistry, Medicinal
Manjinder Singh Phull, Surender Singh Jadav, Rambabu Gundla, Prathama S. Mainkar
Summary: Colorectal cancer is a major cause of carcinogenic mortality, with mutations in the APC gene playing a key role. Current research is focused on developing new anti-colorectal cancer drugs by targeting essential cellular components.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Stephen Arnovitz, Priya Mathur, Melissa Tracy, Azam Mohsin, Soumi Mondal, Jasmin Quandt, Kyle M. Hernandez, Khashayarsha Khazaie, Marei Dose, Akinola Olumide Emmanuel, Fotini Gounari
Summary: This study reveals that aberrant activation of beta-catenin in thymocytes contributes to leukemias by promoting translocations and transformation. Lymphomas resembling T-ALL are sensitive to PARP inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Cell Biology
Yong Ji, Yiqian Liu, Changchun Sun, Lijiang Yu, Zhao Wang, Xu Du, Wu Yang, Chenggong Zhang, Chunmu Tao, Jianjiang Wang, Xi Yang, Sun Di, Yufeng Huang
Summary: Mutations in the Wnt/beta-catenin signaling pathway upstream lead to abnormal activation in colon cancer, and ADCK1 plays a crucial role in promoting cancer progression by interacting with TCF4 to activate the beta-catenin/TCF pathway. This research identifies potential therapeutic targets for colon cancer treatment.
CELL DEATH & DISEASE
(2021)
Review
Medicine, General & Internal
Jun Sun
Summary: Intestinal bacteria play an important role in the development of colorectal cancer, but identifying the specific causative microorganisms remains challenging. This review focuses on the progress of bacterial infection and colorectal cancer, as well as the microbial contribution to cancer characteristics.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Bao Chai, Yarong Guo, Na Zhu, Junmei Jia, Zhuowei Zhang, Mei Ping, Kai Jia, Xiaolong Cui, Yuhong Suo
Summary: In colorectal carcinoma, the APC/beta-catenin signaling cascade transcriptionally activates PLEK2, promoting cell proliferation and colony formation, while knockdown of PLEK2 produces the opposite effects. This interaction may provide a new target for the treatment of colorectal cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Endocrinology & Metabolism
Yasaman Badakhshi, Weijuan Shao, Dinghui Liu, Lili Tian, Juan Pang, Jianqiu Gu, Jim Hu, Tianru Jin
Summary: This study reveals that hepatic FGF21 is downregulated in male LTCFDN mice compared to females, implicating the involvement of estrogen-beta-cat/TCF signaling pathway. In mouse primary hepatocytes, FGF21 transcription is positively regulated by the Wnt pathway effector beta-cat/TCF. Ovariectomized female mice show reduced hepatic FGF21 production, correlated with decreased hepatic TCF expression and beta-catenin phosphorylation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Livia Preisler, Aline Habib, Guy Shapira, Liron Kuznitsov-Yanovsky, Yoav Mayshar, Ilana Carmel-Gross, Mira Malcov, Foad Azem, Noam Shomron, Revital Kariv, Dov Hershkovitz, Dalit Ben-Yosef
Summary: The study found that embryonic stem cells with familial adenomatous polyposis (FAP) and different APC gene mutations may induce molecular defects leading to tumorigenic transformation, while genetic variations may also predict the severity of the disease.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Simon Bernard Iloki Assanga, Lidianys Maria Lewis Lujan, Mark F. McCarty
Summary: Progressive up-regulation of β-catenin signaling is common in CRC transformation. Measures like cGMP/PKG signaling and dietary factors can oppose this signaling and prevent or slow the transformation. Other strategies include selective activation of estrogen receptor β, inhibition of CK2, and assurance of adequate folate status to oppose β-catenin signaling in colorectal epithelium.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Martin R. Graf, Shruti Apte, Esteban Terzo, Simran Padhye, Shuhao Shi, Megan K. Cox, Roger B. Clark, Vijay Modur, Vasudeo Badarinarayana
Summary: Familial adenomatous polyposis (FAP) is a colorectal disease caused by mutations in the APC gene, leading to the growth of adenomatous polyps. The novel macrolide, ZKN-0013, has been shown to restore the function of the APC protein and inhibit the beta-catenin/wnt-pathway in human colon carcinoma cells and a mouse model of FAP. Treatment with ZKN-0013 reduced the number of intestinal polyps, adenomas, anemia, and improved survival.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Oncology
Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen, Chung-Liang Ho
Summary: In this study, a combined bioinformatics and experimental approach was used to identify potential target genes of the Wnt/beta-catenin signaling pathway. It was found that RMI2 is a new target gene of this pathway and that it promotes epithelial-mesenchymal transition markers, hepatocellular carcinoma cell invasion, and metastasis. These findings suggest that RMI2 could be a potential target for preventing or mitigating the progression of hepatocellular carcinoma.
Article
Chemistry, Multidisciplinary
Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue
Summary: This study reveals that transferrin receptor (TFRC) is induced by β-catenin activation driven by APC gene loss in colorectal cancer, and TFRC-mediated intratumoral iron accumulation enhances β-catenin signaling through tankyrase activation. Disruption of TFRC reduces colonic iron levels and iron-dependent tankyrase activity, leading to stabilization of AXIN2 and repression of the β-catenin/c-Myc/E2F Transcription Factor 1/DNA polymerase delta1 (POLD1) axis, causing increased DNA replication stress, DNA damage response, apoptosis, and reduced colon tumor growth. Iron chelation combined with DNA damaging agents further increases DNA damage response and reduces colon tumor cell growth. This discovery may offer new strategies for colorectal cancer therapy.
Article
Food Science & Technology
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu
Summary: This study found that bilberry anthocyanins have a modulating effect on the pathogenesis of Alzheimer's disease. They reduce amyloid plaque load and beta-amyloid 1-42 levels, improve mitochondrial morphology, and decrease NO and ROS levels. In HT22 cells, bilberry anthocyanins also protect against A beta 42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, partly through the upregulation of Mfn2. These findings suggest that bilberry anthocyanins can protect against the development of Alzheimer's disease by restoring mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Chemistry, Medicinal
Zhen Wang, Zilu Li, Haitao Ji
Summary: Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with cancer, and direct targeting of beta-catenin is a promising strategy but challenging. Research has identified potential small-molecule binding sites and summarized bioactive small molecules that target beta-catenin directly.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Multidisciplinary Sciences
Melanie Haas Kucherlapati
Summary: This study examines important mouse models in colorectal cancer (CRC) and discusses their strengths and weaknesses. It also evaluates how these models can be used by researchers in the future. The study highlights the significance of the immune system and tumor microenvironments in CRC progression and treatment.
Article
Immunology
Kevin T. Kline, Haifeng Lian, Xiaoying S. Zhong, Xiuju Luo, John H. Winston, Yingzi Cong, Tor C. Savidge, Roderick H. Dashwood, Don W. Powell, Qingjie Li
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Roderick H. Dashwood
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Jia Li, Sibo Zhao, Minjung Lee, Yue Yin, Jin Li, Yubin Zhou, Leomar Y. Ballester, Yoshua Esquenazi, Roderick H. Dashwood, Peter J. A. Davies, D. Williams Parsons, Xiao-Nan Li, Yun Huang, Deqiang Sun
Review
Biochemistry & Molecular Biology
Shamee Bhattacharjee, Roderick H. Dashwood
Article
Oncology
Ahmet M. Ulusan, Praveen Rajendran, Wan Mohaiza Dashwood, Omer F. Yavuz, Sabeeta Kapoor, Trace A. Gustafson, Michelle Savage, Powel H. Brown, Shizuko Sei, Altaf Mohammed, Eduardo Vilar, Roderick H. Dashwood
Summary: The study suggests that switching erlotinib from continuous to once-a-week dosing at one-quarter of the standard dose, combined with sulindac, effectively inhibits adenomatous polyps in the colon and small intestine, with clinical significance for patients with FAP.
CANCER PREVENTION RESEARCH
(2021)
Article
Oncology
Sabeeta Kapoor, Trace Gustafson, Mutian Zhang, Ying-Shiuan Chen, Jia Li, Nhung Nguyen, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran, Roderick H. Dashwood
Summary: The study showed that epigenetic drug combinations targeting DNA repair factors could induce programmed cell death and eliminate tumors in cancer cells, with promising results in colorectal cancer patients. The examination of ERCC2 expression levels highlighted its significant role in the prognosis of colon cancer patients.
Article
Cell Biology
Ying-Shiuan Chen, Jia Li, Sultan Neja, Sabeeta Kapoor, Jorge Enrique Tovar Perez, Chakrapani Tripathi, Rani Menon, Arul Jayaraman, Kyongbum Lee, Wan Mohaiza Dashwood, Shan Wang, Ke Zhang, Koichi Kobayashi, Praveen Rajendran, Roderick Dashwood
Summary: This study reveals the link between spinach-derived linoleate and butanoate metabolites and anticancer effects in a genetic model of colorectal cancer. Mechanistic studies demonstrate that these metabolites target HDAC activity and the IFN-gamma signaling axis. The clinical translation of these findings could have significant implications for delaying surgical interventions and drug therapies in at-risk patients.
Article
Nutrition & Dietetics
Sabeeta Kapoor, Elisabetta Damiani, Shan Wang, Ravirajan Dharmanand, Chakrapani Tripathi, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran, Roderick Hugh Dashwood
Summary: Epigenetic mechanisms, specifically the deregulation of bromodomain (BRD) functions, play a significant role in colorectal cancer (CRC) and other malignancies. This study shows that overexpression of BRD9 is associated with poor prognostic outcomes in CRC patients. Natural polyphenols such as Epigallocatechin-3-gallate (EGCG), Equol, Quercetin, and Aspalathin were identified as potential BRD9 antagonists, as they reduced colon cancer cell viability, inhibited colony formation, and increased DNA damage and apoptosis.
Article
Immunology
Ying Xiao, Haifeng Lian, Xiaoying S. Zhong, Srikruthi S. Krishnachaitanya, Yingzi Cong, Roderick H. Dashwood, Tor C. Savidge, Don W. Powell, Xiaowei Liu, Qingjie Li
Summary: This study found that MMP-7 was highly expressed in patients with ulcerative colitis and in rodents with experimental colitis. MMP-7 impairs the intestinal epithelial barrier by cleavage of Claudin-7, exacerbating inflammation. This study uncovered Claudin-7 as a novel substrate of MMP-7 in the intestinal epithelium.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shilan Zhang, Sabeeta Kapoor, Chakrapani Tripathi, Jorge Tovar Perez, Nivedhitha Mohan, Wan Mohaiza Dashwood, Ke Zhang, Praveen Rajendran, Roderick Dashwood
NPJ PRECISION ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ying-Shiuan Chen, Jia Li, Rani Menon, Arul Jayaraman, Kyongbum Lee, Yun Huang, Wan Mohaiza Dashwood, Ke Zhang, Deqiang Sun, Roderick H. Dashwood
Summary: The complex interplay between gut microbes, host, and disease outcome is governed by multiple factors, with a multi-omics approach revealing the significant anti-tumor effects of spinach (SPI) in cancer prevention. SPI led to changes in gut microbiome diversity and taxonomic composition, implicating linoleate and butanoate metabolism in cancer pathways. Tumor suppression by SPI involved reshaping of the gut microbiome and alterations in host RNA-miRNA networks. Metabolomic analysis linked anticancer outcomes to linoleate bioactives and changes in glutamate and N-acetylneuraminate associated with oncogenic signaling and immune evasion. Further research on additional factors like fiber content is needed for potential interventions in at-risk patients.
Review
Genetics & Heredity
Roderick H. Dashwood
Summary: Studies have found that chlorophylls and their derivatives can form molecular complexes with environmental heterocyclic amines, aflatoxins, and polycyclic aromatic hydrocarbons, limiting their uptake and bioavailability in vivo. Additionally, chlorophylls exhibit antimutagenic and antigenotoxic effects, leading to research on free radical scavenging, anti-inflammatory effects, immune modulation, and photodynamic therapy.
GENES AND ENVIRONMENT
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)