Review
Pharmacology & Pharmacy
Linshan Duan, Shuyu Cheng, Long Li, Yanling Liu, Dan Wang, Guoyan Liu
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by various factors, with Crohn's disease and ulcerative colitis being the two major types. Most commonly used drugs for IBD have adverse reactions and limited long-term efficacy, leading to challenges in treating patients. Research suggests that natural compounds with anti-inflammatory activities could offer potential therapeutic strategies for IBD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
John Gubatan, Derek R. Holman, Christopher J. Puntasecca, Danielle Polevoi, Samuel J. S. Rubin, Stephan Rogalla
Summary: Antimicrobial peptides play crucial roles in maintaining tolerance to gut microbiota and protecting against infections in the gastrointestinal tract, and are increasingly recognized as potential biomarkers and novel therapeutic targets in the pathogenesis of inflammatory bowel disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Rosa Direito, Joao Rocha, Bruno Sepodes, Maria Eduardo-Figueira
Summary: Non-communicable chronic diseases (NCDs) have become a leading cause of death in industrialized nations due to high fat and sugar diets, stress, and lack of physical activity. Phenolic compounds in diets have antioxidant, anti-inflammatory, and anti-proliferative activities that benefit human health. Overcoming the limited bioavailability of these compounds is important for maximizing their health benefits.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Dulce C. Macias-Ceja, Maria D. Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation is associated with excessive deposition of extracellular matrix and leads to fibrosis. Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), and deregulated autophagy is linked to fibrosis progression. Understanding the role of autophagy in fibrosis may provide new targets for antifibrotic therapy. This review focuses on the relevance of autophagy in fibrosis, with a special emphasis on IBD-related fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Review
Cell & Tissue Engineering
Yusuke Wakisaka, Shinya Sugimoto, Toshiro Sato
Summary: This review discusses the application of adult tissue-derived organoids culture technology to elucidate the pathogenesis of IBD and to develop novel therapies, including regenerative treatments.
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Infectious Diseases
Sara Federici, Denise Kviatcovsky, Rafael Valdes-Mas, Eran Elinav
Summary: Inflammatory bowel disease (IBD) is a group of auto-inflammatory disorders affecting the gastrointestinal tract and other organs. The gut microbiome and specifically bacteriophages, which can infect bacteria, play a role in IBD pathology. Phage therapy shows potential in eradicating pathobionts associated with IBD, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Endocrinology & Metabolism
Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li
Summary: Our study used bidirectional 2-sample Mendelian randomization (MR) to infer a potential causal relationship between Graves disease (GD) and inflammatory bowel disease (IBD). The results suggest that genetically predicted IBD may increase the risk of GD, while Crohn disease (CD) may increase the risk of GD and ulcerative colitis (UC) may protect against GD. However, genetically predicted GD may slightly increase the risk of CD, but there is no evidence that GD increases the risk of UC or IBD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Marina Rodrigues de Abreu, Melissa Carolina Pereira, Patricia Ucelli Simioni, Elen Fernanda Nodari, Lisiery Negrini Paiatto, Maria Izabel Camargo-Mathias
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Immunology
Tassia B. Pessato, Natalia C. de Carvalho, Daniella de Figueiredo, Talita C. Colomeu, Luis Gustavo R. Fernandes, Flavia M. Netto, Ricardo de L. Zollner
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Sidmara Bedin, Flavia Maria Netto, Neura Bragagnolo, Osvaldir P. Taranto
SEPARATION SCIENCE AND TECHNOLOGY
(2020)
Article
Engineering, Chemical
Katia Regina Kuhn, Fernanda Guimaraes Drummond e Silva, Flavia Maria Netto, Rosiane Lopes da Cunha
JOURNAL OF FOOD ENGINEERING
(2019)
Article
Food Science & Technology
Natalia Caldeira de Carvalho, Tassia Batista Pessato, Fernanda Negrao, Marcos Nogueira Eberlin, Jorge Herman Behrens, Ricardo de Lima Zollner, Flavia Maria Netto
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Food Science & Technology
Antonio Bisconsin-Junior, Heber Rodrigues, Jorge H. Behrens, Verena S. Lima, Maria Aparecida Azevedo P. da Silva, Mari Silvia R. de Oliveira, Lorena A. Januario, Rosires Deliza, Flavia Maria Netto, Lilian Regina B. Mariutti
FOOD QUALITY AND PREFERENCE
(2020)
Review
Food Science & Technology
Maria Elisa Caetano-Silva, Flavia Maria Netto, Maria Teresa Bertoldo-Pacheco, Amparo Alegria, Antonio Cilla
Summary: Bioactive peptides derived from food proteins have various bioactivities, including metal-binding capacity. Mineral chelating peptides have the potential to reduce mineral deficiencies and pro-oxidant effects of Fe.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Food Science & Technology
Francielli P. R. de Morais, Tassia B. Pessato, Eliseu Rodrigues, Luana Peixoto Mallmann, Lilian R. B. Mariutti, Flavia M. Netto
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Entomology
Melissa Carolina Pereira, Elen Fernanda Nodari, Marina Rodrigues de Abreu, Lisiery Negrini Paiatto, Patricia Ucelli Simioni, Maria Izabel Camargo-Mathias
Summary: The brown dog tick, as the primary vector of pathogens affecting dogs globally, utilizes bioactive molecules in its saliva to modulate the immune response in host organisms. In vitro experiments show that the salivary gland extract of female dog ticks can induce a decrease in nitric oxide secretion through macrophage activation, demonstrating its potential modulatory effects on the immune system.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2021)
Article
Food Science & Technology
Murilo Luiz Bazon, Luis Gustavo Romani Fernandes, Isabela Oliveira Sandrini Assugeni, Lucas Machado Pinto, Patricia Ucelli Simioni, Ricardo de Lima Zollner, Marcia Regina Brochetto Braga
Summary: The study found that rPoly p 5 does not affect NO production or the expression of co-stimulatory molecules in mouse peritoneal macrophages. However, rPoly p 5 increased IL-1 beta production in non-activated macrophages and decreased TNF-alpha and MCP-1 cytokines production in activated macrophages. The findings suggest an important role of this allergen in modulating M2 macrophage phenotypes, especially in previously activated macrophages.
Article
Biotechnology & Applied Microbiology
Daniel Barbosa Coelho, Lilian Maria Peixoto Lopes, Emerson Cruz de Oliveira, Lenice Kappes Becker, Guilherme de Paula Costa, Helen Hermana Miranda Hermsdorff, Fernanda Guimaraes Drummond e Silva, Kelerson Mauro de Castro Pinto, Andre Talvani, Julia Cristina Cardoso Carraro
Summary: This study investigated the effect of resistance training and dietary advice intervention on elderly people with chronic low-grade inflammation. The results showed that elderly individuals with poor dietary habits before intervention responded better to the program, with greater reductions in weight, BMI, and body fat percentage. Furthermore, a better diet quality, including dietary antioxidant sources, was associated with control of weight and inflammatory biomarkers in the elderly population.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Fernanda Ortolan, Karoline Urbano, Flavia Maria Netto, Caroline Joy Steel
Summary: Research on commercial vital wheat gluten revealed chemical and structural differences among different sources, showcasing variations in elasticity, extensibility, and gluten network structure.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Raquel Carolina Giarola, Roseli Aparecida Ferrari, Ana Clara Troya Raineri Fiocco, Flavia Maria Netto, Rosiane Lopes da Cunha, Elizabeth Harumi Nabeshima, Peter Eisner, Isabel Muranyi, Mitie Sonia Sadahira
Summary: This study evaluated the effects of different ratios of sunflower meal protein (SMP) and pectin (P) at different process parameters on emulsion stabilisation. At room temperature, increasing pectin concentration led to increased viscosity and gel-like behaviour of the biopolymer dispersions and emulsions. However, at a SMP:P ratio of 5:1, the emulsion showed stability regarding creaming, flocculation and/or coalescence. When heat treated, all samples showed low apparent viscosity, but the SMP:P ratio influenced the gel-like behaviour and dispersion structure of the emulsion. Sunflower meal can be used as an ingredient to obtain different food emulsion structures depending on the process parameters.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Juliany Cristiny Sonda Bordignon, Amanda Teixeira Badaro, Douglas Fernandes Barbin, Lilian Regina Barros Mariutti, Flavia Maria Netto
Summary: This study investigated the oxidative susceptibility of whey protein isolate (WPI) dispersions treated by microwave or thermal convection before freeze-drying. The results suggest that microwave heating increased the degree of protein oxidation.
