Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2

(2017) Lance T. Pflieger et al.   HUMAN MOLECULAR GENETICS

Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes

(2017) Biswarathan Ramani et al.   HUMAN MOLECULAR GENETICS

Huntingtin gene repeat size variations affect risk of lifetime depression

(2017) Sarah L. Gardiner et al.   Translational Psychiatry

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice

(2017) Lodewijk J.A. Toonen et al.   Molecular Therapy-Nucleic Acids

Triploid atlantic salmon (Salmo salar L.) post-smolts accumulate prevalence more slowly than diploid salmon following bath challenge with salmonid alphavirus subtype 3

(2017) Lindsey J. Moore et al.   PLoS One

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington’s disease peripheral blood samples

(2016) Anastasios Mastrokolias et al.   Metabolomics

Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow

(2016) Alexandre Seyer et al.   Metabolomics

Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels

(2016) Nesli Ece Sen et al.   NEUROBIOLOGY OF DISEASE

Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways

(2016) Melissa Ingram et al.   NEURON

Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis

(2016) Medi Kori et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

(2016) Eleni Mina et al.   Orphanet Journal of Rare Diseases

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3

(2016) Lodewijk J. A. Toonen et al.   Scientific Reports

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Huntington’s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood

(2015) Anastasios Mastrokolias et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Novel candidate blood-based transcriptional biomarkers of machado-joseph disease

(2015) Mafalda Raposo et al.   MOVEMENT DISORDERS

T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse

(2015) An-Hsun Chou et al.   NEUROPHARMACOLOGY

Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry

(2014) Samia Boudah et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Toward RNAi Therapy for the Polyglutamine Disease Machado–Joseph Disease

(2013) Maria do Carmo Costa et al.   MOLECULAR THERAPY

Association between Machado–Joseph disease and oxidative stress biomarkers

(2013) Laura Segabinazzi Pacheco et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Removing technical variability in RNA-seq data using conditional quantile normalization

(2012) K. D. Hansen et al.   BIOSTATISTICS

Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase ϵ Attenuates Mutant Huntingtin Toxicity

(2012) Ningzhe Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of Mitochondrial DNA Damage in Blood and Brain Tissues of a Transgenic Mouse Model of Machado-Joseph Disease

(2012) Nadiya Kazachkova et al.   Neurodegenerative Diseases

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Summarizing and correcting the GC content bias in high-throughput sequencing

(2012) Yuval Benjamini et al.   NUCLEIC ACIDS RESEARCH

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

(2011) V. G. Shakkottai et al.   JOURNAL OF NEUROSCIENCE

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

(2011) Warwick B Dunn et al.   Nature Protocols

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination

(2011) Mangala M. Soundarapandian et al.   Scientific Reports

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Altered cholesterol and fatty acid metabolism in Huntington disease

(2009) Robert C. Block et al.   Journal of Clinical Lipidology

Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington’s disease

(2009) Caroline M. Forrest et al.   JOURNAL OF NEUROCHEMISTRY

Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease

(2009) Ya-Chun Yu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation

(2009) An-Hsun Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

(2008) Gonzalo Arboleda et al.   BRAIN RESEARCH REVIEWS

SCA3: Neurological features, pathogenesis and animal models

(2008) Olaf Riess et al.   CEREBELLUM

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation

(2008) An-Hsun Chou et al.   NEUROBIOLOGY OF DISEASE