Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer’s Disease?

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

(2018) Nadeeja Wijesekara et al.   FASEB JOURNAL

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and gray mouse lemur (Microcebus murinus )

(2018) Giuliana Pellegrino et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review

(2018) Konstantinos Ioannis Avgerinos et al.   JOURNAL OF NEUROLOGY

Type 2 diabetes in adolescents and young adults

(2018) Nadia Lascar et al.   Lancet Diabetes & Endocrinology

A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes

(2017) Heather Benford et al.   GLIA

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation

(2017) Joshua D. Stover et al.   MOLECULAR THERAPY

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Bidirectional interactions between diabetes and Alzheimer's disease

(2017) Mitsuru Shinohara et al.   NEUROCHEMISTRY INTERNATIONAL

Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

(2017) Wenhan Yu et al.   Nature Communications

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice

(2017) Tsukasa Ohmori et al.   Scientific Reports

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

(2017) Kelsey E. Jarrett et al.   Scientific Reports

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

(2017) Romina María Uranga et al.   Scientific Reports

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

(2016) Jarrad M Scarlett et al.   NATURE MEDICINE

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

(2016) Zayna Chaker et al.   NEUROBIOLOGY OF AGING

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector

(2016) Giridhar Murlidharan et al.   Molecular Therapy-Nucleic Acids

Prss56, a novel marker of adult neurogenesis in the mouse brain

(2015) Alexandre Jourdon et al.   Brain Structure & Function

Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

(2015) Ming-San Ma et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice

(2015) Sudhanshu P. Raikwar et al.   PLoS One

The LIM Homeodomain Factor Lhx2 Is Required for Hypothalamic Tanycyte Specification and Differentiation

(2014) J. Salvatierra et al.   JOURNAL OF NEUROSCIENCE

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes

(2014) Magdiel Salgado et al.   PLoS One

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus

(2013) N. Haan et al.   JOURNAL OF NEUROSCIENCE

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

(2013) S.C. Robins et al.   Nature Communications

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

(2013) Geneviève Marcelin et al.   Molecular Metabolism

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

(2011) Juan A. Orellana et al.   GLIA

ATP-mediated glucosensing by hypothalamic tanycytes

(2011) Cameron Frayling et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Spontaneous In Vivo Differentiation of Embryonic Stem Cell-Derived Pancreatic Endoderm-Like Cells Corrects Hyperglycemia in Diabetic Mice

(2010) Sudhanshu P. Raikwar et al.   TRANSPLANTATION

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin producing cells derived from embryonic stem cells: Are we there yet?

(2008) Sudhanshu P. Raikwar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING