Article
Multidisciplinary Sciences
Vicente Herranz-Perez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel Garcia-Verdugo, Shinya Ohata
Summary: This study found the peak expression of ZFTA in mouse embryos and observed that ZFTA may be regulated by ciliary transcription factors. However, ZFTA is not essential for the development or flow of supratentorial ependymoma.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
David Lopez-Rodriguez, Antoine Rohrbach, Marc Lanzillo, Manon Gervais, Sophie Croizier, Fanny Langlet
Summary: In this study, the development of ependymal cells in the mouse mediobasal hypothalamus was examined using the BrdU approach and publicly available single-cell RNAseq datasets. The results showed that typical ependymal cells are mainly generated at E13, while the generation of tanycytes depends on time and subtypes and lasts until P8. The study also revealed a dorsoventral and rostral-to-caudal pattern in the generation of ependymal cells along the third ventricle.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Victor Baeza, Manuel Cifuentes, Fernando Martinez, Eder Ramirez, Francisco Nualart, Luciano Ferrada, Maria Jose Oviedo, Isabelle De Lima, Ninoschka Troncoso, Natalia Saldivia, Katterine Salazar
Summary: Ependymal cells with multiple apical cilia are important for brain function, and the protein IIIG9 plays a crucial role in maintaining their adherens junctions. Loss of ependymal cell polarity can lead to tumor formation, particularly in children, and understanding the function of IIIG9 may provide insights into potential therapies for conditions such as hydrocephalus or neoplastic transformation.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Biological
Rafik Dali, Judith Estrada-Meza, Fanny Langlet
Summary: Reciprocal communication between neurons and glia is crucial for normal brain functioning and energy balance regulation. Tanycytes, a type of ependymoglial cells, play a multifunctional role in the physiological mechanisms of appetite control, primarily by modulating orexigenic and anorexigenic neurons within neural networks in the hypothalamus and brainstem. Recent studies have highlighted the impact of tanycytes on hypothalamic neuronal activity, particularly in arcuate neurons.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Xiaoqing Zhu, Yicheng Guo, Chu Chu, Dahai Liu, Kui Duan, Yu Yin, Chenyang Si, Yu Kang, Junjun Yao, Xuewei Du, Junliang Li, Shumei Zhao, Zongyong Ai, Qingyuan Zhu, Weizhi Ji, Yuyu Niu, Tianqing Li
Summary: This study found that BRN2 is a conserved gene that plays a key role in primate brain development. Through gene knockout experiments in cynomolgus monkeys, it was found that the absence of BRN2 leads to embryonic death before midgestation and has negative effects on brain development. Further analysis revealed that BRN2 is responsible for controlling the specification and differentiation of ganglionic eminences. Additionally, the study also found that BRN2 has a similar function in retinal ganglion cells of cynomolgus monkeys and humans.
Article
Cell Biology
Maia Uriarte, Pablo N. De Francesco, Gimena Fernandez, Daniel Castrogiovanni, Micaela D'Arcangelo, Monica Imbernon, Sonia Cantel, Severine Denoyelle, Jean-Alain Fehrentz, Jeppe Praetorius, Vincent Prevot, Mario Perello
Summary: The study revealed that circulating ghrelin crosses the blood-CSF barrier mainly through a mechanism involving GHSR, and possibly via a GHSR-independent mechanism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Neurosciences
Harmony Fong, Deborah M. Kurrasch
Summary: The hypothalamus is an important regulator of various homeostatic processes, including circadian rhythms, energy balance, thirst, and thermoregulation. Recent research has revealed the presence of neurogenesis and gliogenesis in the hypothalamic third ventricle, mediated by a population of cells known as tanycytes. These tanycytes resemble radial glia and are located in the floor and ventrolateral walls of the third ventricle, extending into the hypothalamic parenchyma. This review focuses on the developmental origin of tanycytes from embryonic radial glia and their role in the adult neural stem cell niche, which is still not well understood.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Brenda Rocamonde, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Emmanuelle Huillard
Summary: Ependymal cells, derived from radial glia, are crucial for proper cerebrospinal fluid flow and neurogenesis modulation. The transcriptional regulator ID4 plays a significant role in the development and maturation of ependymal cells.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Roxane Pasquettaz, Irina Kolotuev, Antoine Rohrbach, Cathy Gouelle, Luc Pellerin, Fanny Langlet
Summary: The study investigates the neuroanatomical associations between tanycytes and neural cells, particularly in the arcuate nucleus. Tanycytes were found to have subcellular protrusions contacting different neural cells, including NPY and POMC neurons in the arcuate nucleus. The protrusions were observed to contain ribosomes, mitochondria, vesicles, and transporters, indicating dense communications between tanycytes, neurons, and blood vessels.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Medicine, General & Internal
Anne-Laure Barbotin, Nour El Houda Mimouni, Gregory Kuchcinski, Renaud Lopes, Romain Viard, Sowmyalakshmi Rasika, Daniele Mazur, Mauro S. B. Silva, Virginie Simon, Angele Boursier, Jean-Pierre Pruvo, Qiang Yu, Michael Candlish, Ulrich Boehm, Federica Dal Bello, Claudio Medana, Pascal Pigny, Didier Dewailly, Vincent Prevot, Sophie Catteau-Jonard, Paolo Giacobinia
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive-endocrine disorder. This study investigates the brain structure and function in PCOS patients and reveals the role of AMH in regulating fertility and neuroendocrine dysfunction.
Review
Endocrinology & Metabolism
Richard W. Clayton, Robin Lovell-Badge, Christophe Galichet
Summary: The median eminence acts as a vital interface between the hypothalamus and pituitary gland, and contains various non-neuronal cell types that may play a role in regulating neuroendocrine system function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Laura Fontenas, Sarah Kucenas
Summary: MEP glia are derived from lateral floor plate precursors and require foxd3 for delamination and migration out of the spinal cord. Their development also depends on axonally derived neuregulin1, and overexpressing axonal cues can generate additional MEP glia in the spinal cord.
Review
Neurosciences
Yamil Miranda-Negron, Jose E. Garcia-Arraras
Summary: Radial glia-like cells, traditionally associated with the developing nervous system, are also found in the adult central nervous system where they function as neurogenic progenitors in normal homeostasis and injury response. Molecular tools have been used to probe the heterogeneity of these cells and similar cells have been identified in non-vertebrate organisms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Alexandro E. Trevino, Fabian Mueller, Jimena Andersen, Laksshman Sundaram, Arwa Kathiria, Anna Shcherbina, Kyle Farh, Howard Y. Chang, Anca M. Pasca, Anshul Kundaje, Sergiu P. Pasca, William J. Greenleaf
Summary: Genetic perturbations of cortical development can lead to neurodevelopmental disease like autism spectrum disorder (ASD). Mapping the activity of gene-regulatory elements generating a single-cell atlas of gene expression and chromatin accessibility reveals gene regulation by key transcription factors, differentiates glial lineages' expression programs, and identifies lineage-determining TFs. High connection genes in early differentiating cells exhibit an active chromatin state consistent with lineage commitment. Neural network models pinpoint cell-type-specific enrichment of noncoding mutations associated with ASD in individuals and frequently disrupted TF binding sites. This highlights how cell-type-specific mapping can unveil insights into human development and disease programs.
Review
Medicine, General & Internal
Linda Frintrop, Stefanie Trinh, Jochen Seitz, Markus Kipp
Summary: Eating behavior is regulated by hypothalamic circuits, with glia cells potentially playing a role in this process. Recent studies have shown a reduction in the number of astrocytes in an experimental anorexia nervosa model. Anorexia nervosa is associated with brain volume loss and neuropsychological deficits, and the underlying pathophysiology is still unknown. Understanding the role of glia cells in eating disorders, including anorexia nervosa, may lead to the identification of new drug targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anatomy & Morphology
M. P. Madrigal, B. Ballester-Lurbe, O. Gomez, J. A. Moreno-Bravo, E. Puelles, S. Jurado, J. M. Garcia-Verdugo, I. Perez-Roger, Jose Terrado
Summary: Rnd3 is a protein involved in oligodendrocyte maturation, with potential roles in the development of the central nervous system and demyelinating diseases. Its absence leads to hypomyelination, reduced oligodendrocyte numbers, and thinner myelin sheaths in mice, indicating its crucial role in myelination.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Carmen Alcala, Carlos Quintanilla-Bordas, Francisco Gascon, Angel Perez Sempere, Laura Navarro, Maria Carcelen-Gadea, Lamberto Landete, Javier Mallada, Emmanuel Canizares, Antonio Belenguer, Sara Carratala, Jose Andres Dominguez, Francisco Carlos Perez-Miralles, Sara Gil-Perotin, Raquel Gasque, Laura Cubas, Jessica Castillo, Bonaventura Casanova
Summary: This study compared the effectiveness of rituximab and ocrelizumab in patients with primary progressive multiple sclerosis (pwPPMS) under real-life conditions. The findings showed no differences in time to confirmed disability progression between the two treatments. However, further clinical trials are needed to confirm these results.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
C. Alcala, L. Cubas, S. Carratala, F. Gascon, C. Quintanilla-Bordas, S. Gil-Perotin, D. Gorriz, F. Perez-Miralles, R. Gasque, J. Castillo, B. Casanova
Summary: This study confirms the value of NFL levels in monitoring asymptomatic inflammatory activity in the brain caused by GEL, but NFL concentration is not as useful when inflammation occurs only in the spinal cord.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Paula Garcia-Belda, Helena Prima-Garcia, Alicia Aliena-Valero, Maria Castello-Ruiz, Maria Jose Ulloa-Navas, Amadeo Ten-Esteve, Luis Marti-Bonmati, Juan B. Salom, Jose Manuel Garcia-Verdugo, Sara Gil-Perotin
Summary: Mesenchymal stem cell therapy after stroke shows promise, but the viability of cells may be compromised.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mercedes F. Paredes, Cristina Mora, Quetzal Flores-Ramirez, Arantxa Cebrian-Silla, Ashley Del Dosso, Phil Larimer, Jiapei Chen, Gugene Kang, Susana Gonzalez Granero, Eric Garcia, Julia Chu, Ryan Delgado, Jennifer A. Cotter, Vivian Tang, Julien Spatazza, Kirsten Obernier, Jaime Ferrer Lozano, Maximo Vento, Julia Scott, Colin Studholme, Tomasz J. Nowakowski, Arnold R. Kriegstein, Michael C. Oldham, Andrea Hasenstaub, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Eric J. Huang
Summary: Research has revealed that the human embryonic ventral forebrain contains nests of proliferative neuroblasts which play a crucial role in generating a sufficient number of functional interneurons for the human brain.
Editorial Material
Multidisciplinary Sciences
Arturo Alvarez-Buylla, Arantxa Cebrian-Silla, Shawn F. Sorrells, Marcos Assis Nascimento, Mercedes F. Paredes, Jose Manuel Garcia-Verdugo, Zhengang Yang, Eric J. Huang
Summary: This study lacks evidence to support the link between proliferating cells and neurogenesis, the role of multipolar nestin(+) astrocytes as progenitors, and the identity of mature-looking doublecortin+ neurons as adult-born. The histology-marker expression observed differs from species with well-documented adult hippocampal neurogenesis.
Article
Clinical Neurology
Raquel Baviera-Munoz, Lidon Carretero-Vilarroig, Nuria Muelas, Rafael Sivera, Pablo Sopena-Novales, Begona Martinez-Sanchis, Isabel Sastre-Bataller, Marina Campins-Romeu, Irene Martinez-Torres, Jose Manuel Garcia-Verdugo, Jose M. Millan, Teresa Jaijo, Elena Aller, Luis Bataller
Summary: SCA36 is a common cause of hereditary ataxia in Eastern Spain, with a strong founder effect. Its clinical features include hypoacusis, pyramidal signs, lingual fasciculations/atrophy, dystonia, and parkinsonism. SCA36 analysis should be considered as a priority in the study of hereditary ataxia, especially in patients with late onset.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, Research & Experimental
Laura Martinez-Ruiz, Javier Florido, Cesar Rodriguez-Santana, Alba Lopez-Rodrigueza, Ana Guerra-Librero, Beatriz I. Fernandez-Gild, Patricia Garcia-Tarraga, Jose Manuel Garcia-Verdugo, Felix Oppel, Holger Sudhoff, David Sanchez-Porras, Amadeo Ten-Steve, Jose Fernandez-Martinez, Pilar Gonzalez-Garcia, Iryna Rusanova, Dario Acuna-Castroviejoa, Victor Carriel, Germaine Escames
Summary: The study investigates the mechanisms for increasing melatonin bioavailability in head and neck squamous cell carcinoma (HNSCC) and its potential as an adjuvant to improve cisplatin therapeutic efficacy. The results demonstrate that intratumoral injection of melatonin significantly inhibits tumor progression and enhances the effects of cisplatin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Alba Ortega-Gasco, Antoni Parcerisas, Keiko Hino, Vicente Herranz-Perez, Fausto Ulloa, Alba Elias-Tersa, Miquel Bosch, Jose Manuel Garcia-Verdugo, Sergi Simo, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2 plays a significant role in the regulation of RGPs during adult neurogenesis and corticogenesis.
Article
Biochemistry & Molecular Biology
Alejandra Suarez-Carrillo, Monica Alvarez-Cordoba, Ana Romero-Gonzalez, Marta Talaveron-Rey, Suleva Povea-Cabello, Paula Cilleros-Holgado, Rocio Pinero-Perez, Diana Reche-Lopez, David Gomez-Fernandez, Jose Manuel Romero-Dominguez, Manuel Munuera-Cabeza, Antonio Diaz, Susana Gonzalez-Granero, Jose Manuel Garcia-Verdugo, Jose A. Sanchez-Alcazar
Summary: In this study, autophagic defects and secondary pathological consequences were demonstrated in cellular models derived from patients with WDR45 mutations in beta-propeller protein-associated neurodegeneration (BPAN). The study showed that WDR45 mutations impaired autophagy, iron metabolism, and cell bioenergetics. While antioxidants partially improved cellular physiopathology, autophagy and cell bioenergetics remained affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrian-Silla, Susana Gonzalez-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric J. Huang, Ethan A. Winkler, Mercedes F. Paredes, Rothem Kovner, Nenad Sestan, Alex A. Pollen, Pengyuan Liu, Jingjing Li, Xianhua Piao, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Zhandong Liu, Arnold R. Kriegstein
Summary: This study generates a cross-species proteomic map of synapse development in the neocortex of human, macaque and mouse. The results show that human PSDs mature slower than other species and contain higher levels of Rho guanine nucleotide exchange factors in the perinatal period. In addition, PSD proteins can be divided into four modules that exert stage- and cell-type-specific functions. The findings provide insights into the molecular basis and evolutionary changes of synapse maturation.
Article
Cell Biology
Kimberly K. Hoi, Wenlong Xia, Ming Ming Wei, Maria Jose Ulloa Navas, Jose-Manuel Garcia Verdugo, Maxence Nachury, Jeremy F. Reiter, Stephen P. J. Fancy
Summary: Remyelination after white matter injury (WMI) often fails in diseases like multiple sclerosis due to improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions. Primary cilia play a crucial role in the OPC response to WMI through the GPCR/cAMP/CREB signaling axis.
Article
Biology
Daniel A. Lee, Grigorios Oikonomou, David A. Prober
Summary: Zebrafish is a valuable model for studying vertebrate sleep behavior, as it shows behavioral, genetic, and pharmacological similarities with mammals. Researchers have developed a protocol for conducting sleep behavioral experiments in zebrafish larvae, providing guidelines for experiment setup and data analysis. This method is simple, cost-effective, and can be used for genetic and pharmacological screens to gain insights into the genetic and neurological mechanisms underlying sleep regulation.
Article
Multidisciplinary Sciences
Vicente Herranz-Perez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel Garcia-Verdugo, Shinya Ohata
Summary: This study found the peak expression of ZFTA in mouse embryos and observed that ZFTA may be regulated by ciliary transcription factors. However, ZFTA is not essential for the development or flow of supratentorial ependymoma.
SCIENTIFIC REPORTS
(2022)