High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin

Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

(2017) Daisuke Ariyasu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Short-Term Fructose Feeding Induces Inflammation and Oxidative Stress in the Hippocampus of Young and Adult Rats

(2017) Luisa Cigliano et al.   MOLECULAR NEUROBIOLOGY

Chronic Fructose Ingestion as a Major Health Concern: Is a Sedentary Lifestyle Making It Worse? A Review

(2017) Amy Bidwell   Nutrients

Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

(2017) Rodrigo Pereira et al.   Nutrients

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

(2017) Manuela Aragno et al.   Nutrients

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

(2016) Tiinamaija Tuomi et al.   Cell Metabolism

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

(2016) Yunan Wang et al.   Scientific Reports

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress

(2015) Miguel Baena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Diacylglycerol Signaling Pathway in Pancreatic β-Cells: An Essential Role of Diacylglycerol Kinase in the Regulation of Insulin Secretion

(2015) Yukiko K. Kaneko et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity

(2015) Robert H. Eckel et al.   CURRENT BIOLOGY

Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats

(2015) Ji Hun Park et al.   Evidence-based Complementary and Alternative Medicine

Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance

(2015) Mona S. Ottum et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Dietary glycemia as a determinant of health and longevity

(2015) Elizabeth A. Whitcomb et al.   MOLECULAR ASPECTS OF MEDICINE

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

(2014) Sergio T. Ferreira et al.   Alzheimers & Dementia

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of the Effects of Fructose on Oxidative Stress and Inflammatory Parameters in Rat Brain

(2014) Abigail Lopes et al.   MOLECULAR NEUROBIOLOGY

Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening

(2014) Patricia Rubio-Sastre et al.   SLEEP

Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women

(2013) C. J. McMullan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease

(2013) Ian A. Clark et al.   BIOCHEMICAL PHARMACOLOGY

Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

(2013) Eleni N. Tsakiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides

(2013) Meiju Äijälä et al.   Genes and Nutrition

Melatonin in Alzheimer’s Disease

(2013) Li Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats

(2013) Daniel Cardinali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance

(2012) Mark Naples et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

(2012) Zafar Rasheed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

(2012) T. Otoda et al.   DIABETES

‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition

(2012) Rahul Agrawal et al.   JOURNAL OF PHYSIOLOGY-LONDON

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance

(2012) Lu-Ping Ren et al.   PLoS One

ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease

(2012) Koji Hashida et al.   PLoS One

Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

(2011) Stephanie Seneff et al.   European Journal of Internal Medicine

Melatonin improves metabolic syndrome induced by high fructose intake in rats

(2011) Akira Kitagawa et al.   JOURNAL OF PINEAL RESEARCH

Use of hamster as a model to study diet-induced atherosclerosis

(2011) Alice Dillard et al.   Nutrition & Metabolism

Diet-induced metabolic hamster model of nonalcoholic fatty liver disease

(2011) Satya Prakash et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Evidence-Based Review on the Effect of Normal Dietary Consumption of Fructose on Blood Lipids and Body Weight of Overweight and Obese Individuals

(2010) Laurie C. Dolan et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers

(2010) David de Gonzalo-Calvo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Fructose Intake as a Risk Factor For Dementia

(2010) B. C. M. Stephan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

(2009) Yoshio Nagai et al.   Cell Metabolism

Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?

(2009) Richard J. Johnson et al.   ENDOCRINE REVIEWS

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures

(2008) Carolyn A. Rankin et al.   NEUROBIOLOGY OF DISEASE