The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

A Nontoxic Concentration of Cisplatin Induces Autophagy in Cervical Cancer

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Autophagy promotesBrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism

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Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

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Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells

(2014) Ming-Feng Wei et al.   Autophagy

Ras in digestive oncology

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Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

(2014) Ramya Lakshminarayan et al.   NATURE CELL BIOLOGY

KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers

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Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

(2013) Hugo Lavoie et al.   Nature Chemical Biology

Galectin-9 Activates and Expands Human T-Helper 1 Cells

(2013) Marloes J. M. Gooden et al.   PLoS One

pH-Dependent Recycling of Galectin-3 at the Apical Membrane of Epithelial Cells

(2013) Tamara Straube et al.   TRAFFIC

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

(2012) X. Liao et al.   CLINICAL CANCER RESEARCH

K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc

(2012) Kirti Magudia et al.   JOURNAL OF CELL BIOLOGY

The Glycan-Binding Protein Galectin-9 Has Direct Apoptotic Activity toward Melanoma Cells

(2012) Valerie R. Wiersma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

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Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9–dependent mechanism

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Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

(2011) Rafael B. Blasco et al.   CANCER CELL

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

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Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic potential of Galectin-9 in human disease

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C-Raf Is Required for the Initiation of Lung Cancer by K-Ras G12D

(2011) Florian A. Karreth et al.   Cancer Discovery

Autophagy is a therapeutic target in anticancer drug resistance

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Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells

(2010) Dominik Schneider et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF

(2010) Nityanand Maddodi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

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Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells

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Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

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Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice

(2008) Atsuya Nobumoto et al.   CLINICAL IMMUNOLOGY

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

(2008) A. Nobumoto et al.   GLYCOBIOLOGY

Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers

(2008) Ludovic Barault et al.   INTERNATIONAL JOURNAL OF CANCER

Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma

(2008) Meiyan Liang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Structural Analysis of the Human Galectin-9 N-terminal Carbohydrate Recognition Domain Reveals Unexpected Properties that Differ from the Mouse Orthologue

(2007) Masamichi Nagae et al.   JOURNAL OF MOLECULAR BIOLOGY