EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

Molecular targets of oxidative stress

(2011) Simon V. Avery   BIOCHEMICAL JOURNAL

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans

(2011) A. Segref et al.   GENETICS

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

(2011) Kirsten Kuhlbrodt et al.   NATURE CELL BIOLOGY

Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-γ, and IP3R activation

(2010) Hiroaki Iwasa et al.   AGING CELL

Growth hormone, insulin and aging: The benefits of endocrine defects

(2010) Andrzej Bartke   EXPERIMENTAL GERONTOLOGY

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

(2010) W. Niu et al.   GENOME RESEARCH

The ERK-MAPK Pathway Regulates Longevity through SKN-1 and Insulin-like Signaling inCaenorhabditis elegans

(2010) Tetsuya Okuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Identification of Carbonylated Proteins and Their Oxidation Sites

(2010) Ashraf G. Madian et al.   JOURNAL OF PROTEOME RESEARCH

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

A photoconvertible reporter of the ubiquitin-proteasome system in vivo

(2010) Geert Hamer et al.   NATURE METHODS

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins

(2009) Hassane S. Mchaourab et al.   BIOCHEMISTRY

Protein Pool Maintenance During Oxidative Stress

(2009) B. Catalgol et al.   CURRENT PHARMACEUTICAL DESIGN

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

(2009) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

(2008) Nicolle Breusing et al.   BIOLOGICAL CHEMISTRY

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Nonenzymatic posttranslational protein modifications in ageing

(2008) Vukić Šoškić et al.   EXPERIMENTAL GERONTOLOGY

The HECT Domain of TRIP12 Ubiquitinates Substrates of the Ubiquitin Fusion Degradation Pathway

(2008) Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

(2008) C. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA