Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells

E6AP promotes prostate cancer by reducing p27 expression

(2017) Dinesh Raghu et al.   Oncotarget

Impact of Alternative Splicing on the Human Proteome

(2017) Yansheng Liu et al.   Cell Reports

Clusterin: full-length protein and one of its chains show opposing effects on cellular lipid accumulation

(2017) Suvarsha Rao Matukumalli et al.   Scientific Reports

Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells

(2016) Andrei P. Drabovich et al.   MOLECULAR & CELLULAR PROTEOMICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

(2016) P J Paul et al.   ONCOGENE

SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer

(2016) Yingying Cheng et al.   TUMOR BIOLOGY

Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers

(2016) Anja M. Billing et al.   Scientific Reports

The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors

(2015) Edgar R. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer

(2015) Chunyu Wang et al.   NUCLEIC ACIDS RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome

(2015) V Tomaić et al.   Cell Death & Disease

Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death

(2014) S. E. Birch et al.   ANNALS OF ONCOLOGY

Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and Gβγ-dependent pathways

(2014) Byeong-Ho Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleotide Excision Repair-dependent DNA Double-strand Break Formation and ATM Signaling Activation in Mammalian Quiescent Cells

(2014) Mitsuo Wakasugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Inducible Factor-1α Directly Regulates Nuclear Clusterin Transcription by Interacting with Hypoxia Response Elements in the Clusterin Promoter

(2014) Jeongsook Park et al.   MOLECULES AND CELLS

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

(2013) Karoline Kollmann et al.   CANCER CELL

Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10

(2013) So Young Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteomic Profiling in Drosophila Reveals Potential Dube3a Regulation of the Actin Cytoskeleton and Neuronal Homeostasis

(2013) Laura Jensen et al.   PLoS One

E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha

(2013) Pooja Pal et al.   PLoS One

E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation

(2013) P Pal et al.   Cell Death & Disease

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

(2012) K. Wolyniec et al.   BLOOD

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Multiple Functions of Sushi Domain Containing 2 (SUSD2) in Breast Tumorigenesis

(2012) A. P. Watson et al.   MOLECULAR CANCER RESEARCH

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress

(2012) K Wolyniec et al.   ONCOGENE

Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis

(2011) Xian Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Combination therapy of recurrent prostate cancer with the proteasome inhibitor bortezomib plus hormone blockade

(2011) Andrew S. Kraft et al.   CANCER BIOLOGY & THERAPY

Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression

(2011) Sabina Pucci et al.   CELL CYCLE

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene

(2011) Jessica DelBove et al.   Epigenetics

Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer

(2011) M. Shiota et al.   MOLECULAR CANCER RESEARCH

E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts

(2011) Y Levav-Cohen et al.   ONCOGENE

E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth

(2010) Sathish Srinivasan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Clusterin Facilitates COMMD1 and I- B Degradation to Enhance NF- B Activity in Prostate Cancer Cells

(2010) A. Zoubeidi et al.   MOLECULAR CANCER RESEARCH

Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line

(2010) Christine Vogel et al.   Molecular Systems Biology

Smarcc1 expression: A significant predictor of disease-specific survival in patients with clinically localized prostate cancer treated with no intention to cure

(2010) Rehne Lessman Hansen et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

The ubiquitin-proteasome system in prostate cancer and its transition to castration resistance

(2010) Ioannis A. Voutsadakis et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

The clusterin paradigm in prostate and breast carcinogenesis

(2009) Federica Rizzi et al.   ENDOCRINE-RELATED CANCER

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells

(2009) Federica Rizzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture

(2009) Raja Jothi et al.   Molecular Systems Biology

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

(2009) Amit Mishra et al.   NEUROBIOLOGY OF DISEASE

Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread

(2009) S Bettuzzi et al.   ONCOGENE

Proteomic Interrogation of Androgen Action in Prostate Cancer Cells Reveals Roles of Aminoacyl tRNA Synthetases

(2009) Adaikkalam Vellaichamy et al.   PLoS One

Ubiquitin ligase E6-AP and its role in human disease

(2008) Konstantin Matentzoglu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6

(2008) Li Zheng et al.   GENES TO CELLS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Aminoacyl tRNA synthetases and their connections to disease

(2008) S. G. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA