The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors

Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism

(2014) Karina Kjær et al.   BMC CELL BIOLOGY

Viral Phosphodiesterases That Antagonize Double-Stranded RNA Signaling to RNase L by Degrading 2-5A

(2014) Robert H. Silverman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Murine AKAP7 Has a 2',5'-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

(2014) E. Gusho et al.   mBio

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

(2013) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

(2013) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

(2013) Frédéric Sorgeloos et al.   PLoS Pathogens

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of human phosphodiesterase 12 and identification of a novel 2′-5′ oligoadenylate nuclease – The ectonucleotide pyrophosphatase/phosphodiesterase 1

(2012) Jesper B. Poulsen et al.   BIOCHIMIE

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

(2012) Ling Zhao et al.   Cell Host & Microbe

Plant Actin-binding Protein SCAB1 Is Dimeric Actin Cross-linker with Atypical Pleckstrin Homology Domain

(2012) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

(2011) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

(2011) Jesper Buchhave Poulsen et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

High yield synthesis, purification and characterisation of the RNase L activators 5′-triphosphate 2′–5′-oligoadenylates

(2010) B. Morin et al.   ANTIVIRAL RESEARCH

Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity

(2010) Hui Wang et al.   EMBO JOURNAL

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

(2010) H. Elbahesh et al.   VIROLOGY

A central role for RNA in the induction and biological activities of type 1 interferons

(2010) Xiao-Ling Li et al.   Wiley Interdisciplinary Reviews-RNA

Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

(2009) R.-J. Lin et al.   JOURNAL OF IMMUNOLOGY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY