Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

(2017) Juan F Martín et al.   JOURNAL OF ANTIBIOTICS

wblA , a pleiotropic regulatory gene modulating morphogenesis and daptomycin production in Streptomyces roseosporus

(2017) X. Huang et al.   JOURNAL OF APPLIED MICROBIOLOGY

Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces

(2017) Gao-Yi Tan et al.   ACS Synthetic Biology

Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145

(2017) Catherine Esnault et al.   Scientific Reports

Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production

(2016) Tierrafría Víctor H. et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model

(2016) Lanqing Dang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Product Discovery through Improved Functional Metagenomics in Streptomyces

(2016) Hala A. Iqbal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66

(2016) Huiming Huang et al.   Microbial Cell Factories

Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster

(2016) Oksana Bilyk et al.   PLoS One

Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin byStreptomyces globisporus

(2015) Xingxing Li et al.   MOLECULAR MICROBIOLOGY

RSAT 2015: Regulatory Sequence Analysis Tools

(2015) Alejandra Medina-Rivera et al.   NUCLEIC ACIDS RESEARCH

Pikromycin production stimulation through antibiotic down-regulatory gene disruption in Streptomyces venezuelae

(2015) Min-Woo Woo et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Insights into naturally minimised Streptomyces albus J1074 genome

(2014) Nestor Zaburannyi et al.   BMC GENOMICS

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Repression of Antibiotic Downregulator WblA by AdpA in Streptomyces coelicolor

(2013) Han-Na Lee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Carbon-Flux Distribution within Streptomyces coelicolor Metabolism: A Comparison between the Actinorhodin-Producing Strain M145 and Its Non-Producing Derivative M1146

(2013) Fabien Coze et al.   PLoS One

Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold

(2013) Zengyi Shao et al.   ACS Synthetic Biology

Genome-wide Distribution of AdpA, a Global Regulator for Secondary Metabolism and Morphological Differentiation in Streptomyces, Revealed the Extent and Complexity of the AdpA Regulatory Network

(2012) A. Higo et al.   DNA RESEARCH

Minimal polyketide pathway expression in an actinorhodin cluster-deleted and regulation-stimulated Streptomyces coelicolor

(2012) Han-Na Lee et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Negative Role of wblA in Response to Oxidative Stress in Streptomyces coelicolor

(2012) Jin-Su Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters

(2012) Dimitris Kallifidas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Streptomyces ghanaensis pleiotropic regulatory gene wblA gh influences morphogenesis and moenomycin production

(2011) Mariia Rabyk et al.   BIOTECHNOLOGY LETTERS

The actinobacteria-specific gene wblA controls major developmental transitions in Streptomyces coelicolor A3(2)

(2011) K. Fowler-Goldsworthy et al.   MICROBIOLOGY-SGM

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

(2011) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Putative TetR Family Transcriptional Regulator SCO1712 Encodes an Antibiotic Downregulator in Streptomyces coelicolor

(2010) H. N. Lee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement

(2009) Jun-Hee Noh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor

(2008) Dan Shu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Antibiotic Overproduction inStreptomyces coelicolorA3(2) Mediated by Phosphofructokinase Deletion

(2008) Irina Borodina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of the rare UUA codon to define “Expression Space” for genes involved in secondary metabolism, development and environmental adaptation in Streptomyces

(2008) Keith F. Chater et al.   JOURNAL OF MICROBIOLOGY