Carbohydrate-based vaccines for oncotherapy

Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody–drug conjugates

(2017) Feng Tang et al.   Nature Protocols

IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

(2017) Xu-Guang Yin et al.   ORGANIC LETTERS

Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

(2016) Alberto Fernández-Tejada et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines

(2016) Danyang Feng et al.   ACS Chemical Biology

Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates

(2016) Chengcheng Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement

(2016) Rony Dahan et al.   CANCER CELL

Delivery of foreign cytotoxic T lymphocyte epitopes to tumor tissues for effective antitumor immunotherapy against pre-established solid tumors in mice

(2016) Herbert W. Kavunja et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Synthetic MUC1 Antitumor Vaccine Candidates with Varied Glycosylation Pattern BearingR/S-configured Pam3CysSerLys4

(2016) Lei Shi et al.   CHEMBIOCHEM

Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides

(2016) Z. Y. Sun et al.   CHEMICAL COMMUNICATIONS

Synthesis and Evaluation of Glycoconjugates ComprisingN-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines

(2016) Shuang Sun et al.   ChemMedChem

A retrospective analysis of the Alzheimer's disease vaccine progress - The critical need for new development strategies

(2016) Dante J. Marciani   JOURNAL OF NEUROCHEMISTRY

Synthesis of an Aminooxy Derivative of the Tetrasaccharide Repeating Unit of Streptococcus dysgalactiae 2023 Polysaccharide for a PS A1 Conjugate Vaccine

(2016) Samir Ghosh et al.   JOURNAL OF ORGANIC CHEMISTRY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines

(2016) An Xiao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Immunological evaluation of the entirely carbohydrate-based Thomsen-Friedenreich – PS B conjugate

(2016) Kevin R. Trabbic et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

(2016) E. Stronen et al.   SCIENCE

CAR T Cell Therapy: A Game Changer in Cancer Treatment

(2016) Hilde Almåsbak et al.   Journal of Immunology Research

A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission

(2016) Roisin O’Cearbhaill et al.   Cancers

Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine

(2015) Zhaojun Yin et al.   ACS Chemical Biology

Glycopeptide Nanoconjugates Based on Multilayer Self-Assembly as an Antitumor Vaccine

(2015) Yan-Fang Liu et al.   BIOCONJUGATE CHEMISTRY

Synthesis and cell-selective antitumor properties of amino acid conjugated tumor-associated carbohydrate antigen-coated gold nanoparticles

(2015) Souvik Biswas et al.   CARBOHYDRATE RESEARCH

Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies

(2015) Zhaojun Yin et al.   CHEMBIOCHEM

Identification of potential pancreatic cancer serum markers: Increased sialyl-Lewis X on ceruloplasmin

(2015) Meritxell Balmaña et al.   CLINICA CHIMICA ACTA

Carbohydrate-based vaccine adjuvants – discovery and development

(2015) Jing Hu et al.   Expert Opinion on Drug Discovery

Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen

(2015) Xiu-Jing Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic and immunological studies of N-acyl modified S-linked STn derivatives as anticancer vaccine candidates

(2015) Chang-Xin Huo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Synthesis of Natural and Non-natural Thomsen-nouveau Antigens and Hydrazide Derivatives

(2015) Ahmad Ali Shaik et al.   ORGANIC LETTERS

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

(2015) Zhifang Zhou et al.   Chemical Science

A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells

(2015) Lei Qiu et al.   Oncotarget

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

A Cancer Therapeutic Vaccine based on Clustered Tn-Antigen Mimetics Induces Strong Antibody-Mediated Protective Immunity

(2014) Barbara Richichi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Multivalent Glycopeptide-Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells

(2014) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer Immunotherapy and Breaking Immune Tolerance: New Approaches to an Old Challenge

(2014) A. Makkouk et al.   CANCER RESEARCH

Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines

(2014) Yue Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preclinical studies with JAA-F11 anti-Thomsen-Friedenreich monoclonal antibody for human breast cancer

(2014) Kimiko Ferguson et al.   Future Oncology

Synthesis of an Aminooxy Derivative of the Trisaccharide Globotriose Gb3

(2014) Samir Ghosh et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Immunogenicity Study of Globo H Analogues with Modification at the Reducing or Nonreducing End of the Tumor Antigen

(2014) Hsin-Yu Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the tumor associative α-aminooxy disaccharide of the TF antigen and its conjugation to a polysaccharide immune stimulant

(2014) Jean Paul Bourgault et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

(2014) Zhifang Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

(2014) Y.-W. Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating structural features of an entirely carbohydrate cancer vaccine construct employing circular dichroism and fluorescent labeling

(2014) Kevin R. Trabbic et al.   MedChemComm

Immune checkpoints

(2014) Akhil Chawla et al.   OncoImmunology

Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids

(2013) Zhaojun Yin et al.   ACS Chemical Biology

Self-Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T-Cell Epitopes from Tetanus Toxoid

(2013) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Adjuvant Ganglioside GM2-KLH/QS-21 Vaccination Versus Observation After Resection of Primary Tumor > 1.5 mm in Patients With Stage II Melanoma: Results of the EORTC 18961 Randomized Phase III Trial

(2013) Alexander M.M. Eggermont et al.   JOURNAL OF CLINICAL ONCOLOGY

A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

(2013) Rebecca M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines

(2013) Alison L. Parry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer

(2013) Y.-L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response

(2012) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens

(2012) Zhaojun Yin et al.   BIOCONJUGATE CHEMISTRY

Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants

(2012) Colleen Olive   Expert Review of Vaccines

Carbohydrate-based cancer vaccines: target cancer with sugar bullets

(2012) Chang-Cheng Liu et al.   GLYCOCONJUGATE JOURNAL

Design of Fully Synthetic, Self-Adjuvanting Vaccine Incorporating the Tumor-Associated Carbohydrate Tn Antigen and Lipoamino Acid-Based Toll-like Receptor 2 Ligand

(2012) Abu-Baker M. Abdel-Aal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse

(2011) Qianli Wang et al.   ACS Chemical Biology

Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues

(2011) Nikola Gaidzik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards a Fully Synthetic MUC1-Based Anticancer Vaccine: Efficient Conjugation of Glycopeptides with Mono-, Di-, and Tetravalent Lipopeptides Using Click Chemistry

(2011) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antigen cross-presentation: extending recent laboratory findings to therapeutic intervention

(2011) T. W. H. Flinsenberg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

(2011) Govind Ragupathi et al.   Expert Review of Vaccines

Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development

(2011) Rangaiah Shashidharamurthy et al.   MEDICINAL RESEARCH REVIEWS

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

Cancer vaccines and carbohydrate epitopes

(2011) Jamie Heimburg-Molinaro et al.   VACCINE

Synthetic and Immunological Studies of sTn Derivatives Carrying Substituted Phenylacetylsialic Acids as Cancer Vaccine Candidate

(2011) Qianli Wang et al.   ACS Medicinal Chemistry Letters

Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen

(2010) Fan Yang et al.   ACS Chemical Biology

Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen-Friedenreich Antigen and a Fluorine-Substituted Analogue

(2010) Anja Hoffmann-Röder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stable GM3Lactone Mimetic Raises Antibodies Specific for the Antigens Expressed on Melanoma Cells

(2010) Annarosa Arcangeli et al.   BIOCONJUGATE CHEMISTRY

Transglucosidases as efficient tools for oligosaccharide and glucoconjugate synthesis

(2010) Pierre Monsan et al.   CURRENT OPINION IN MICROBIOLOGY

Identification and functions of pattern-recognition receptors

(2010) Yutaro Kumagai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Random Glycopeptide Bead Libraries for Seromic Biomarker Discovery

(2010) Stjepan K. Kračun et al.   JOURNAL OF PROTEOME RESEARCH

Synthesis of a Single-Moleculel-Rhamnose-Containing Three-Component Vaccine and Evaluation of Antigenicity in the Presence of Anti-l-Rhamnose Antibodies

(2010) Sourav Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

(2010) Sung You Hong et al.   NATURE MATERIALS

Control of malaria

(2010) Santwana Kar et al.   NATURE REVIEWS DRUG DISCOVERY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoparticle Delivery Systems in Cancer Vaccines

(2010) Yogita Krishnamachari et al.   PHARMACEUTICAL RESEARCH

Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity

(2010) Olivier Renaudet et al.   PLoS One

Overview of the development and current use of CRM197 conjugate vaccines for pediatric use

(2010) Henry R. Shinefield   VACCINE

A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

(2009) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems

(2009) Brad M. Rosen et al.   CHEMICAL REVIEWS

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Therapeutic vaccines in solid tumours: Can they be harmful?

(2009) Alexander M.M. Eggermont   EUROPEAN JOURNAL OF CANCER

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates

(2009) Ravindra A. De Silva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer-Based Therapeutics

(2009) Shuang Liu et al.   MACROMOLECULES

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine

(2008) Kai Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic and Immunological Studies of5′-N-Phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins

(2008) Qianli Wang et al.   BIOCONJUGATE CHEMISTRY

Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines

(2008) Tanja D. de Gruijl et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cowpea Mosaic Virus Capsid: A Promising Carrier for the Development of Carbohydrate Based Antitumor Vaccines

(2008) Adeline Miermont et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation

(2008) Ayesha Murshid et al.   Expert Review of Vaccines

Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis

(2008) W.-W. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA