Small-molecule inhibitors of multidrug resistance-associated protein 1 and related processes: A historic approach and recent advances

Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2)

(2017) Michael K. Krapf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pantoprazole Induces Apoptosis of Leukemic Cells by Inhibiting Expression of P-Glycoprotein/Multidrug Resistance-Associated Protein-1 Through PI3K/AKT/mTOR Signaling

(2017) Miao Liu et al.   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-Mediated Multidrug Resistance

(2017) Pranav Gupta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2)

(2017) Michael K. Krapf et al.   JOURNAL OF MEDICINAL CHEMISTRY

9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein

(2017) Katja Stefan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel Triazolonaphthalimide Derivative LSS-11 Synergizes the Anti-Proliferative Effect of Paclitaxel via STAT3-Dependent MDR1 and MRP1 Downregulation in Chemoresistant Lung Cancer Cells

(2017) Liyan Ji et al.   MOLECULES

High-content screening of clinically tested anticancer drugs identifies novel inhibitors of human MRP1 (ABCC1)

(2017) Brian G. Peterson et al.   PHARMACOLOGICAL RESEARCH

Pantoprazole Induces Apoptosis of Leukemic Cells by Inhibiting Expression of P-Glycoprotein/Multidrug Resistance-Associated Protein-1 Through PI3K/AKT/mTOR Signaling

(2017) Miao Liu et al.   Indian Journal of Hematology and Blood Transfusion

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

(2017) Himangshu Sonowal et al.   Scientific Reports

Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter

(2016) Sebastian C. Köhler et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway

(2016) JIE-RU CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2)

(2016) Michael K. Krapf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1)

(2016) Sven Marcel Schmitt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro

(2015) Daniela Cihalova et al.   BIOCHEMICAL PHARMACOLOGY

MRP1 and its role in anticancer drug resistance

(2015) Jamie F. Lu et al.   DRUG METABOLISM REVIEWS

Design of inhibitors of BCRP/ABCG2

(2015) Kapil Juvale et al.   Future Medicinal Chemistry

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells

(2015) S.F. Chen et al.   GENETICS AND MOLECULAR RESEARCH

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2)

(2015) Sebastian C. Köhler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Celecoxib sensitizes imatinib-resistant K562 cells to imatinib by inhibiting MRP1–5, ABCA2 and ABCG2 transporters via Wnt and Ras signaling pathways

(2015) Gangappa Dharmapuri et al.   LEUKEMIA RESEARCH

Lapatinib sensitizes quiescent MDA-MB-231 breast cancer cells to doxorubicin by inhibiting the expression of multidrug resistance-associated protein-1

(2015) YUN-SUK KWON et al.   ONCOLOGY REPORTS

Upregulation of Multidrug Resistance-Associated Protein 1 by Allyl Isothiocyanate in Human Bronchial Epithelial Cell: Involvement of c-Jun N-Terminal Kinase Signaling Pathway

(2015) Shujun Wang et al.   Oxidative Medicine and Cellular Longevity

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

(2014) Doriane Lorendeau et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity

(2014) Jennifer Gallus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Thieno[2,3-b]pyridines—A new class of multidrug resistance (MDR) modulators

(2014) Aivars Krauze et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro,in vivoandex vivocharacterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1

(2014) Hui Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

3β-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activity

(2014) Gleice da Graça Rocha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin

(2014) Matthew D. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2014) Shao-lin Ma et al.   MOLECULAR MEDICINE

Effect and mechanism of Src tyrosine kinase inhibitor sunitinib on the drug-resistance reversal of human A549/DDP cisplatin-resistant lung cancer cell line

(2014) KE ZHANG et al.   Molecular Medicine Reports

Flavonostilbenes fromSophora alopecuroidesL. as multidrug resistance associated protein 1 (MRP1) inhibitors

(2014) Kai Ni et al.   NATURAL PRODUCT RESEARCH

Allyl Isothiocyanate Increases MRP1 Function and Expression in a Human Bronchial Epithelial Cell Line

(2014) Dian-lei Wang et al.   Oxidative Medicine and Cellular Longevity

Targeting Multidrug Resistance Protein 1 (MRP1, ABCC1): Past, Present, and Future

(2013) Susan P.C. Cole   Annual Review of Pharmacology and Toxicology

Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2)

(2013) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

(2013) Shibo Lin et al.   Cancer Cell International

Caffeic acid phenethyl ester induces E2F-1-mediated growth inhibition and cell-cycle arrest in human cervical cancer cells

(2013) Tzu-Hui Hsu et al.   FEBS Journal

The function of the ATP-binding cassette (ABC) transporter ABCB1 is not susceptible to actin disruption

(2012) Peter Meszaros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

(2012) Nicola A. Colabufo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

4-Substituted-2-phenylquinazolines as inhibitors of BCRP

(2012) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Marilines A-C: Novel Phthalimidines from the Sponge-Derived Fungus Stachylidium sp.

(2012) Celso Almeida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tyrosine Kinase Inhibitors Influence ABCG2 Expression in EGFR-Positive MDCK BCRP Cells via the PI3K/Akt Signaling Pathway

(2012) Anne Pick et al.   ChemMedChem

Collateral sensitivity as a strategy against cancer multidrug resistance

(2012) Kristen M. Pluchino et al.   DRUG RESISTANCE UPDATES

An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1

(2012) Yu Lei et al.   FOOD CHEMISTRY

Effects of 3β-Acethyl Tormentic Acid (3ATA) on ABCC Proteins Activity

(2012) Gleice da Graça Rocha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1)

(2012) Sean P. Ebert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavopiridol, the First Cyclin-Dependent Kinase Inhibitor: Recent Advances in Combination Chemotherapy

(2012) L.-M. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Isothiocyanate–drug interactions in the human adenocarcinoma cell line Caco-2

(2012) Katarzyna Lubelska et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner

(2012) Mohammed-Amine El Azreq et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: Glutathione reduction and MRP1 downregulation

(2012) HAOLU WANG et al.   ONCOLOGY REPORTS

FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1

(2011) W. Garrido et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors

(2011) Kalam Sirisha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein

(2011) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression

(2011) Cai-Guo Ye et al.   CANCER LETTERS

Identification of Xanthones as Selective Killers of Cancer Cells Overexpressing the ABC Transporter MRP1

(2011) Estelle Genoux-Bastide et al.   ChemMedChem

Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin

(2011) Andrew S. Goldsborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Galloyl-Based Selective Modulators Targeting Multidrug Resistance Associated Protein 1 and P-glycoprotein

(2011) Raffaella Zoe Pellicani et al.   JOURNAL OF MEDICINAL CHEMISTRY

The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes

(2011) Maria Brandmann et al.   JOURNAL OF NEUROCHEMISTRY

Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells

(2011) Sen Li et al.   PHYTOMEDICINE

Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression

(2010) Sin Ho Kweon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1

(2010) Régis Barattin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP)

(2010) Anne Pick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

(2010) Y.-j. Mi et al.   CANCER RESEARCH

Specific Inhibitors of the Breast Cancer Resistance Protein (BCRP)

(2010) Anne Pick et al.   ChemMedChem

8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1

(2010) Olga Wesołowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines

(2010) W. F. W. Bierman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rofecoxib augments anticancer effects by reversing intrinsic multidrug resistance gene expression in BGC-823 gastric cancer cells

(2010) Feng Shang ZHU et al.   Journal of Digestive Diseases

Phenylsulfonylfuroxans as Modulators of Multidrug-Resistance-Associated Protein-1 and P-Glycoprotein

(2010) Roberta Fruttero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Multidrug Resistance-Related Protein 1 (MRP1) Function and Localization Depend on Cortical Actin

(2010) I. Hummel et al.   MOLECULAR PHARMACOLOGY

A Single-Arm Phase II Trial of First-Line Paclitaxel in Combination with Lapatinib in HER2-Overexpressing Metastatic Breast Cancer

(2010) Agnieszka Jagiello-Gruszfeld et al.   ONCOLOGY

Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: A report from the Children's Oncology Group

(2010) Maureen M. O'Brien et al.   PEDIATRIC BLOOD & CANCER

Identification of the Efflux Transporter of the Fluoroquinolone Antibiotic Ciprofloxacin in Murine Macrophages: Studies with Ciprofloxacin-Resistant Cells

(2009) B. Marquez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir

(2009) Omar Janneh et al.   ANTIVIRAL THERAPY

Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance

(2009) Ye-Hong Kuang et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators

(2009) Werner Klinkhammer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells

(2009) Alessandro Ascione et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function

(2009) Li-yang Tao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reversal of P-glycoprotein-Mediated Multidrug Resistance by the Murine Double Minute 2 Antagonist Nutlin-3

(2009) M. Michaelis et al.   CANCER RESEARCH

Small-Molecule Multidrug Resistance-Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

(2009) C. A. Burkhart et al.   CANCER RESEARCH

Multi-Drug-Resistance-Reverting Agents: 2-Aryloxazole and 2-Arylthiazole Derivatives as Potent BCRP or MRP1 Inhibitors

(2009) Nicola A. Colabufo et al.   ChemMedChem

Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure-Activity Relationships

(2009) Kin-Fai Chan et al.   ChemMedChem

A Multi-Institutional Phase II Study of the Efficacy and Tolerability of Lapatinib in Patients with Advanced Hepatocellular Carcinomas

(2009) T. Bekaii-Saab et al.   CLINICAL CANCER RESEARCH

Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)

(2009) K. Maeno et al.   DRUG METABOLISM AND DISPOSITION

Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Multidrug Resistance by Bivalent Apigenin Homodimers and Their Derivatives

(2009) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar

(2009) Matthias Kühnle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aromatic 2-(Thio)ureidocarboxylic Acids As a New Family of Modulators of Multidrug Resistance-Associated Protein 1: Synthesis, Biological Evaluation, and Structure−Activity Relationships

(2009) Hans-Georg Häcker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals

(2009) Tomohiro Nabekura et al.   PHARMACOLOGICAL RESEARCH

Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

(2009) Li-sheng Zheng et al.   PLoS One

Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells – Study of structure–activity relationship

(2009) I. Slaninová et al.   TOXICOLOGY IN VITRO

Is resistance useless? Multidrug resistance and collateral sensitivity

(2009) Matthew D. Hall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of human glutathioneS-transferases by curcumin and analogues

(2009) R. Appiah-Opong et al.   XENOBIOTICA

High-Throughput Flow Cytometry to Detect Selective Inhibitors of ABCB1, ABCC1, and ABCG2 Transporters

(2008) Irena Ivnitski-Steele et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1

(2008) Tomohiro Nabekura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversal of P-Glycoprotein and Multidrug Resistance-Associated Protein 1 Mediated Multidrug Resistance in Cancer Cells by HZ08 Isomers, Tetrataisohydroquinolin Derivatives

(2008) Fang Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Structure–activity relationships of new inhibitors of breast cancer resistance protein (ABCG2)

(2008) Anne Pick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins

(2008) Stefan Leyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses

(2008) David Cameron et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals

(2008) Tomohiro Nabekura et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

(2008) C.-l. Dai et al.   CANCER RESEARCH

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2

(2008) S. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Emtricitabine: Inhibitor and substrate of multidrug resistance associated protein

(2008) Laurence Bousquet et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1

(2008) Tomohiro Nabekura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phase III Study of Valspodar (PSC 833) Combined With Paclitaxel and Carboplatin Compared With Paclitaxel and Carboplatin Alone in Patients With Stage IV or Suboptimally Debulked Stage III Epithelial Ovarian Cancer or Primary Peritoneal Cancer

(2008) Catherine Lhommé et al.   JOURNAL OF CLINICAL ONCOLOGY

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer

(2008) G. Filomeni et al.   MOLECULAR CANCER THERAPEUTICS

Assessment of Golgi Apparatus versus Plasma Membrane-Localized Multi-Drug Resistance-Associated Protein 1

(2008) Allyn M. Kaufmann et al.   MOLECULAR PHARMACEUTICS

Pharmacogenomics Approach Reveals MRP1 (ABCC1)-Mediated Resistance to Geldanamycins

(2008) Anh-Nhan Pham et al.   PHARMACEUTICAL RESEARCH