Article
Chemistry, Medicinal
I-Ting Wu, Chan-Yen Kuo, Ching-Hui Su, Yu-Hsuan Lan, Chin-Chuan Hung
Summary: This study investigated the inhibitory effects of pinostrobin and tectochrysin on P-gp in MDR cancer cells and the underlying mechanisms. The results showed that these compounds were not substrates of P-gp and did not affect its expression, but they noncompetitively inhibited the efflux of rhodamine 123 and doxorubicin through P-gp, leading to the resensitization of MDR cancer cells. Therefore, pinostrobin and tectochrysin are effective P-gp inhibitors and potential candidates for resensitizing MDR cancer cells.
Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sofija Jovanovic Stojanov, Epole N. Ntungwe, Jelena Dinic, Ana Podolski-Renic, Milica Pajovic, Patricia Rijo, Milica Pesic
Summary: Coleon U, a natural compound not recognized as a substrate of P-glycoprotein, has equal efficacy against sensitive and multidrug-resistant cancer cells. It delays the decrease in P-glycoprotein activity by decreasing mitochondrial membrane potential and inhibiting P-glycoprotein expression.
Article
Chemistry, Physical
Damian Krzyzanowski, Marcin Kruszewski, Agnieszka Grzelak
Summary: Silver nanoparticles (AgNPs) have unique properties that have attracted significant attention, showing antibacterial, antifungal, and anticancer properties. However, they can also exhibit cytotoxic effects and modulate the activity and expression of ABC transporters.
Retraction
Oncology
S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan, D. Velmurugan
Summary: A correction to this paper has been published and is accessible through the original article.
Review
Biochemistry & Molecular Biology
Manuela Labbozzetta, Paola Poma, Monica Notarbartolo
Summary: Acute myeloid leukemia (AML) is difficult to treat due to the development of resistance to both traditional chemotherapy and new drugs in some patients. Multidrug resistance (MDR) in AML is often caused by the overexpression of P-glycoprotein (P-gp), which is an efflux pump. This mini-review focuses on the advantages of using natural substances as inhibitors of P-gp, including phytol, curcumin, lupeol, and heptacosane, and their mechanisms of action in AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pradhapsingh Bharathiraja, David S. P. Cardoso, N. Rajendra Prasad, Silva Mulhovo, Deepa S. Lakra, Maria-Jose U. Ferreira
Summary: This study found that derivatives of N-alkylated monoterpene indole alkaloids, particularly N-(para-bromobenzyl) (NBBT), can reverse P-gp-mediated multidrug resistance in cancer cells. NBBT exhibited the highest P-gp inhibitory activity and reduced P-gp overexpression by inhibiting the nuclear translocation of the nuclear factor kappa B p-50 subunit. Additionally, NBBT showed synergistic effects with doxorubicin, decreasing the cellular migration and increasing apoptotic incidence in drug-resistant cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Oncology
Yichen Tian, Yongrong Lei, Yani Wang, Jiejuan Lai, Jianhua Wang, Feng Xia
Summary: This review summarizes the mechanisms of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp), including the regulation of efflux activity, the inhibition of P-gp expression, and the knockout of the ABCB1 gene. Inhibiting P-gp through screening and designing suitable compounds and techniques can overcome P-gp-mediated MDR, providing a reference for studying the reversal of P-gp-mediated MDR.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
M. Ganesan, G. Kanimozhi, B. Pradhapsingh, Haseeb A. Khan, Abdullah S. Alhomida, Aishah Ekhzaimy, G. R. Brindha, N. Rajendra Prasad
Summary: The review discusses the role of natural phytochemicals in modulating ABCB1 gene expression through various signal transduction pathways in MDR cancer cells, suggesting an alternative approach to reversing MDR by downregulating P-glycoprotein expression in tumor tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Harlan L. Pietz, Ata Abbas, Zachary Lee Johnson, Michael L. Oldham, Hiroaki Suga, Jue Chen
Summary: This study identifies a macrocyclic peptide CPI1 that inhibits the function of MRP1 and blocks substrate transport. The findings suggest that CPI1 could be a potential therapeutic candidate.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Khalid Hussain Wali Sait, Bilal Bin Hafeez, Manish Kumar Tripathi, Badrah Saeed Alghamdi, Hani S. H. Mohammed Ali, Mahmood Rasool
Summary: This study determined the binding affinity and potential interaction sites of the multidrug resistance protein 1 (MRP1) with various anticancer drugs using homology modelling and molecular docking analysis. The results suggested that Carboplatin could be an appropriate therapeutic choice against MRP1 in ovarian cancer, and combining Carboplatin with Gemcitabine may overcome multidrug resistance phenotype.
Article
Agronomy
Tan Dai, Zhiwen Wang, Xingkai Cheng, Huige Gao, Li Liang, Pengfei Liu, Xili Liu
Summary: Both fungicide efflux and detoxification metabolism are involved in the resistance mechanisms of Phytophthora capsici to SYP-14288.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Oncology
Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh Ambudkar
Summary: In this study, we investigate the role of P-glycoprotein (P-gp) in the reduced sensitivity of cancer cells to the anaplastic lymphoma kinase (ALK) inhibitor ensartinib. Our results demonstrate that P-gp overexpression decreases the intracellular accumulation and cytotoxic activity of ensartinib in cancer cells. These findings highlight the importance of understanding the mechanisms of ensartinib resistance mediated by P-gp.
Article
Biochemistry & Molecular Biology
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: The research demonstrates that treating media with CAPP for 180 seconds significantly reduces cell viability and migration of MDA-MB-231 cells, while also disrupting the life processes of MCF7 cells. Furthermore, CAPP-activated media leads to the apoptosis of the analyzed cell lines, especially the metastatic MDA-MB-231 cell line. This suggests that the application of the CAPP system may serve as a potential therapeutic strategy for managing highly metastatic human breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Palko-Labuz, Anna Gliszczynska, Magdalena Skonieczna, Andrzej Pola, Olga Wesolowska, Kamila Sroda-Pomianek
Summary: The study found that conjugates of anisic and veratric acid with phosphatidylcholine could enhance their anticancer effects and selectively target melanoma cells, while also increasing their antioxidant activity. Conjugates substituted by phenolic acid at both the sn-1 and sn-2 positions of phosphatidylcholine appeared to be the most promising.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Palko-Labuz, Maria Blaszczyk, Kamila Sroda-Pomianek, Olga Wesolowska
Summary: Isobavachalcone (IBC) is an active substance from the medicinal plant Psoralea corylifolia with antioxidative, anti-inflammatory, antibacterial, and anticancer activities. Studies have shown that IBC can benefit MDR cancer cells by interfering with the lipid phase of cellular membrane and ABCB1 transporter.
Article
Biochemistry & Molecular Biology
Andrzej Pola, Anna Palko-Labuz, Kamila Sroda-Pomianek
Summary: Phenothiazines are synthetic antipsychotic drugs with diverse biological effects, where the chemical structure and quantum properties play a significant role in drug behavior. Quantum chemical calculations are valuable in predicting the activity of phenothiazines and other drugs with heterocyclic systems. In addition, theoretical analysis revealed the ability of compounds to scavenge free radicals and identified intramolecular hydrogen bonds within the investigated compounds.
Article
Oncology
Anna Palko-Labuz, Jerzy Maksymowicz, Beata Sobieszczanska, Agnieszka Wikiera, Magdalena Skonieczna, Olga Wesolowska, Kamila Sroda-Pomianek
Summary: Colorectal cancer (CRC) is the second leading cause of cancer mortality globally. Irinotecan, commonly used in CRC treatment, can be metabolized by colonic bacteria back to its active form, leading to severe side effects. This study found that novel apple pectin (PC) enhanced the anticancer effects of irinotecan while reducing bacterial enzyme activity that causes side effects, making PC a promising adjunct to irinotecan therapy.
Article
Biochemistry & Molecular Biology
Honorata Kraskiewicz, Piotr Hinc, Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Danuta Witkowska, Isma Liza Mohd Isa, Abhay Pandit, Aleksandra Klimczak
Summary: A potential treatment for chronic wounds using a hydrogel loaded with secretome from adipose tissue mesenchymal stem cells has been proposed. The biocompatibility and pro-angiogenic activity of the hydrogel-released factors were investigated, showing positive effects on skin-origin cell proliferation and endothelial cell angiogenic properties. Additionally, antimicrobial activity was observed in the secretome, indicating its potential use as an advanced wound-healing dressing in combination with the hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Paprocka, Honorata Kraskiewicz, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Leszek Maslowski, Agnieszka Czyzewska-Buczynska, Wojciech Witkiewicz, Danuta Dus, Anna Czarnecka
Summary: The immortalized MSCs line derived from human adipose tissue (HATMSC1) was found to produce biologically active factors that enhance cell proliferation, adhesion, and endothelial cell function. These factors produced under different culture conditions could be used for various medical conditions, suggesting their potential applications in regenerative medicine and inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczenko, Aleksandra Klimczak
Summary: MSCs, known for their regenerative and immunomodulatory properties, are typically isolated from bone marrow and adipose tissue. This review focuses on MSCs derived from adipose tissue and their secretome in regeneration processes, with a special emphasis on their contribution to angiogenic processes. Various clinical trials have been registered to explore the application of AT-MSCs and their secretome in treating different medical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Jerzy Maksymowicz, Anna Palko-Labuz, Beata Sobieszczanska, Mateusz Chmielarz, Miroslawa Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesolowska, Kamila Sroda-Pomianek
Summary: This study investigated the anti-cancer and anti-inflammatory activities of two modified pectins isolated from apple pomace. The pectins exhibited anti-cancer effects by reducing cell viability, inducing apoptosis, and increasing reactive oxygen species. They also showed synergy with SN-38, a common component of colon cancer treatment. Furthermore, the pectins demonstrated significant anti-inflammatory activity and their interaction with galectin-3 and TLR4 was suggested to be responsible for their effects.
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.