Microfluidic approaches for probing amyloid assembly and behaviour

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

(2018) Kadi L. Saar et al.   LAB ON A CHIP

Self-assembled Protein Fibril-metal Oxide Nanocomposites

(2017) A. Levin et al.   ISRAEL JOURNAL OF CHEMISTRY

A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation

(2017) Tyler J. Perlenfein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of Aβ(17–36) in the Presence of Naturally Occurring Phenolic Inhibitors Using Coarse-Grained Simulations

(2017) Yiming Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid fibril systems reduce, stabilize and deliver bioavailable nanosized iron

(2017) Yi Shen et al.   Nature Nanotechnology

Gradient-free determination of isoelectric points of proteins on chip

(2017) Urszula Łapińska et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Silk micrococoons for protein stabilisation and molecular encapsulation

(2017) Ulyana Shimanovich et al.   Nature Communications

Droplet Microfluidic System with On-Demand Trapping and Releasing of Droplet for Drug Screening Applications

(2016) Matthew Courtney et al.   ANALYTICAL CHEMISTRY

A novel method to predict protein aggregations using two-dimensional native protein microfluidic chip electrophoresis

(2016) Shiyong Yu et al.   Analytical Methods

A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions

(2016) Therese W. Herling et al.   BIOPHYSICAL JOURNAL

Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform

(2016) Kadi-Liis Saar et al.   BIOPHYSICAL JOURNAL

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

(2016) Thomas O. Mason et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Droplet-based magnetic bead immunoassay using microchannel-connected multiwell plates (μCHAMPs) for the detection of amyloid beta oligomers

(2016) Min Cheol Park et al.   LAB ON A CHIP

Surface Roughness Modulates Diffusion and Fibrillation of Amyloid-β Peptide

(2016) Khurram Shezad et al.   LANGMUIR

Amyloid–carbon hybrid membranes for universal water purification

(2016) Sreenath Bolisetty et al.   Nature Nanotechnology

Elastic instability-mediated actuation by a supra-molecular polymer

(2016) Aviad Levin et al.   Nature Physics

Fluctuations in the Kinetics of Linear Protein Self-Assembly

(2016) Thomas C. T. Michaels et al.   PHYSICAL REVIEW LETTERS

Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)

(2016) Fabrice Gielen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transthyretin variants with improved inhibition of β-amyloid aggregation

(2016) Parth Mangrolia et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Quantitative thermophoretic study of disease-related protein aggregates

(2016) Manuel Wolff  et al.   Scientific Reports

Micro- and nanoscale hierarchical structure of core–shell protein microgels

(2016) Lisa R. Volpatti et al.   Journal of Materials Chemistry B

Functional imaging of neuron–astrocyte interactions in a compartmentalized microfluidic device

(2016) Yandong Gao et al.   Microsystems & Nanoengineering

Superhydrophobic Surfaces Boost Fibril Self-Assembly of Amyloid β Peptides

(2015) Angelo Accardo et al.   ACS Applied Materials & Interfaces

Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry

(2015) Xiao-Ming Zhou et al.   ACS Nano

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

(2015) Paolo Arosio et al.   ACS Nano

Protein Microgels from Amyloid Fibril Networks

(2015) Ulyana Shimanovich et al.   ACS Nano

Amyloid Templated Gold Aerogels

(2015) Gustav Nyström et al.   ADVANCED MATERIALS

Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers

(2015) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

Effects of Hydrophobic Macromolecular Crowders on Amyloid β (16–22) Aggregation

(2015) David C. Latshaw et al.   BIOPHYSICAL JOURNAL

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Present state of microchip electrophoresis: State of the art and routine applications

(2015) Eric R. Castro et al.   JOURNAL OF CHROMATOGRAPHY A

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

(2015) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Biopolymers and supramolecular polymers as biomaterials for biomedical applications

(2015) Ronit Freeman et al.   MRS BULLETIN

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

(2015) Emma V. Yates et al.   Nature Chemistry

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution

(2015) Therese W. Herling et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Force generation by the growth of amyloid aggregates

(2015) Therese W. Herling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adsorption at Liquid Interfaces Induces Amyloid Fibril Bending and Ring Formation

(2014) Sophia Jordens et al.   ACS Nano

Pharmaceutical amyloidosis associated with subcutaneous insulin and enfuvirtide administration

(2014) Anita D’Souza et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

(2014) Michael Werner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered Lysozyme Amyloid Fibril Networks Support Cellular Growth and Spreading

(2014) Nicholas P. Reynolds et al.   BIOMACROMOLECULES

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoscale spatially resolved infrared spectra from single microdroplets

(2014) Thomas Müller et al.   LAB ON A CHIP

Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips

(2014) A. Ruiz et al.   LAB ON A CHIP

Multiphase Protein Microgels

(2014) Ulyana Shimanovich et al.   MACROMOLECULAR BIOSCIENCE

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatial Propagation of Protein Polymerization

(2014) S. I. A. Cohen et al.   PHYSICAL REVIEW LETTERS

Actin-dependent plastid movement is required for motive force generation in directional nuclear movement in plants

(2014) T. Higa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-assembled tunable networks of sticky colloidal particles

(2014) Arnaud Demortière et al.   Nature Communications

Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution

(2013) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step

(2013) T. W. Herling et al.   APPLIED PHYSICS LETTERS

Microfluidic immunomagnetic cell separation using integrated permanent micromagnets

(2013) O. Osman et al.   Biomicrofluidics

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

(2013) Wayne W. Poon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-dimension microchip-capillary electrophoresis device for determination of functional proteins in infant milk formula

(2013) Ruige Wu et al.   JOURNAL OF CHROMATOGRAPHY A

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Single-cell analysis and sorting using droplet-based microfluidics

(2013) Linas Mazutis et al.   Nature Protocols

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation

(2013) Hansang Cho et al.   Scientific Reports

Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow

(2013) Yoon Jung Choi et al.   Scientific Reports

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios

(2012) Fabio Bianco et al.   ANALYTICAL CHEMISTRY

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Hierarchical Supramolecular Spinning of Nanofibers in a Microfluidic Channel: Tuning Nanostructures at a Dynamic Interface

(2012) Munenori Numata et al.   CHEMISTRY-A EUROPEAN JOURNAL

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular History of the Amyloidoses

(2012) Joel N. Buxbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Microfluidics Reveals a Flow-Induced Large-Scale Polymorphism of Protein Aggregates

(2012) Vito Foderà et al.   Journal of Physical Chemistry Letters

Rapid screening of antibiotic toxicity in an automated microdroplet system

(2012) Krzysztof Churski et al.   LAB ON A CHIP

Droplet microfluidics for high-throughput biological assays

(2012) Mira T. Guo et al.   LAB ON A CHIP

Development of automated paper-based devices for sequential multistep sandwich enzyme-linked immunosorbent assays using inkjet printing

(2012) Amara Apilux et al.   LAB ON A CHIP

Simultaneous Control of pH and Ionic Strength during Interfacial Rheology of β-Lactoglobulin Fibrils Adsorbed at Liquid/Liquid Interfaces

(2012) Patrick A. Rühs et al.   LANGMUIR

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

(2011) Anat Frydman-Marom et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Nanomechanics of functional and pathological amyloid materials

(2011) Tuomas P. J. Knowles et al.   Nature Nanotechnology

Observation of spatial propagation of amyloid assembly from single nuclei

(2011) T. P. J. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free-Flow Zone Electrophoresis of Peptides and Proteins in PDMS Microchip for Narrow pI Range Sample Prefractionation Coupled with Mass Spectrometry

(2010) Yong-Ak Song et al.   ANALYTICAL CHEMISTRY

Microfluidic droplets: new integrated workflows for biological experiments

(2010) Balint Kintses et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity

(2010) Jermont Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

(2010) Alexander K. Buell et al.   PHYSICAL REVIEW LETTERS

Elongated oligomers in  2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

(2010) D. P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput injection with microfluidics using picoinjectors

(2010) A. R. Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

(2010) J. J. Agresti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Analysis of Alzheimer’s β-Amyloid Aggregation Using a Microfluidic Self-Assembly of Monomersf

(2009) Joon Seok Lee et al.   ANALYTICAL CHEMISTRY

Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices

(2009) Andres W. Martinez et al.   ANALYTICAL CHEMISTRY

Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides

(2009) Matthias Meier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On-chip technologies for multidimensional separations

(2009) Samuel Tia et al.   LAB ON A CHIP

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

β-Amyloid impairs axonal BDNF retrograde trafficking

(2009) Wayne W. Poon et al.   NEUROBIOLOGY OF AGING

Self-assembly of protein amyloids: A competition between amorphous and ordered aggregation

(2009) Chiu Fan Lee   PHYSICAL REVIEW E

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Silk Fiber Assembly Studied by Synchrotron Radiation SAXS/WAXS and Raman Spectroscopy

(2008) Anne Martel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monodisperse droplet generation and rapid trapping for single molecule detection and reaction kinetics measurement

(2008) Neil Reginald Beer et al.   LAB ON A CHIP

Microfluidic Self-Assembly of Insulin Monomers into Amyloid Fibrils on a Solid Surface

(2008) Joon Seok Lee et al.   LANGMUIR

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

(2008) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH