Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines

(2017) Neill J. Horley et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells

(2016) Xin Yu et al.   CELL PROLIFERATION

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells

(2016) Carlos Quintana et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis

(2016) Xueran Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes

(2016) Weiru Jiang et al.   TOXICOLOGY LETTERS

Melatonin, an inhibitory agent in breast cancer

(2016) Elaheh Nooshinfar et al.   Breast Cancer

Sulfation of melatonin: Enzymatic characterization, differences of organs, species and genders, and bioactivity variation

(2015) Xiangge Tian et al.   BIOCHEMICAL PHARMACOLOGY

Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity

(2015) Lingmin Yuan et al.   BIOCHEMICAL PHARMACOLOGY

Design and Synthesis of New α-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression

(2015) Jiahua Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

(2015) Chongxi Fan et al.   JOURNAL OF PINEAL RESEARCH

Anatomical and cellular localization of melatonin MT1and MT2receptors in the adult rat brain

(2015) Baptiste Lacoste et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction

(2014) Seema Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Melatonin Inhibits the Migration of Human Lung Adenocarcinoma A549 Cell Lines Involving JNK/MAPK Pathway

(2014) Qiaoyun Zhou et al.   PLoS One

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mechanisms Involved in the Pro-Apoptotic Effect of Melatonin in Cancer Cells

(2013) Carmen Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin

(2012) G García-Santos et al.   BRITISH JOURNAL OF CANCER

Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines

(2012) Marina Sánchez-Hidalgo et al.   JOURNAL OF PINEAL RESEARCH

A novel enzyme-dependent melatonin metabolite in humans

(2012) Chaoyue Li et al.   JOURNAL OF PINEAL RESEARCH

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model

(2012) Kil-Jung Kim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

(2010) Shi-Young Park et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY