Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

(2018) Frank K. Leusink et al.   BMC CANCER

Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome

(2018) Hua Bai et al.   EXPERIMENTAL CELL RESEARCH

Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease

(2018) Bangling Zhang et al.   FASEB JOURNAL

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon

(2018) Natalia V. Fedorova et al.   MEDIATORS OF INFLAMMATION

Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis

(2018) Martine Lambelet et al.   Cell Death & Disease

TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

(2018) Heather Flanagan-Steet et al.   Cell Reports

Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

(2018) Yaping Wang et al.   PLoS Pathogens

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

(2017) Raquel Alvarado et al.   FASEB JOURNAL

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid

(2017) Can Cai et al.   INFLAMMATION

Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid–binding protein

(2017) Simeon Thibeaux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

New trends on obesity and NAFLD in Asia

(2017) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

The role of Kupffer cells in hepatic diseases

(2017) Peizhi Li et al.   MOLECULAR IMMUNOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells

(2017) Kyung-Min Yang et al.   Cell Reports

Metabolically Healthy Obesity and the Development of Nonalcoholic Fatty Liver Disease

(2016) Yoosoo Chang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation

(2016) Álvaro de Mingo et al.   Cell Death & Disease

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation

(2015) Virginia Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Development of new fatty liver, or resolution of existing fatty liver, over five years of follow-up, and risk of incident hypertension

(2014) Ki-Chul Sung et al.   JOURNAL OF HEPATOLOGY

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

(2013) Yuka Fukuo et al.   HEPATOLOGY RESEARCH

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY