Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision

Characterization of Clinical Cases of Advanced Papillary Renal Cell Carcinoma via Comprehensive Genomic Profiling

(2018) Sumanta K. Pal et al.   EUROPEAN UROLOGY

Recommendations for the Management of Rare Kidney Cancers

(2017) Rachel H. Giles et al.   EUROPEAN UROLOGY

Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma

(2017) James J. Hsieh et al.   EUROPEAN UROLOGY

Exceptional Response to Temsirolimus in a Metastatic Clear Cell Renal Cell Carcinoma With an Early Novel MTOR -Activating Mutation

(2017) Juan Francisco Rodríguez-Moreno et al.   Journal of the National Comprehensive Cancer Network

Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

(2017) Robert J. Motzer et al.   Journal of the National Comprehensive Cancer Network

Preservation of truncal genomic alterations in clear cell and papillary renal cell carcinomas with sarcomatoid features: An intra- and intertumoral, multifocal fluorescence in situ hybridization analysis reveals limited genetic heterogeneity

(2017) Joseph M. Sanfrancesco et al.   MOLECULAR CARCINOGENESIS

Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model

(2017) Guillermo de Velasco et al.   ONCOLOGIST

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/−clear cell renal carcinoma

(2017) Wenhua Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer

(2017) James J. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Renal cell carcinoma: a critical analysis of metabolomic biomarkers emerging from current model systems

(2017) Daniela Rodrigues et al.   Translational Research

Characterizing recurrent and lethal small renal masses in clear cell renal cell carcinoma using recurrent somatic mutations

(2017) Brandon J. Manley et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Pan-urologic cancer genomic subtypes that transcend tissue of origin

(2017) Fengju Chen et al.   Nature Communications

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

(2017) Amrita M. Nargund et al.   Cell Reports

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors

(2017) Takatsugu Okegawa et al.   EBioMedicine

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

(2016) A. Ari Hakimi et al.   CANCER CELL

Therapeutic Guide for mTOuRing through the Braided Kidney Cancer Genomic River

(2016) M. H. Voss et al.   CLINICAL CANCER RESEARCH

Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma

(2016) D. J. Kwiatkowski et al.   CLINICAL CANCER RESEARCH

SMARCB1/INI1 Genetic Alterations in Renal Medullary Carcinomas

(2016) Antonio Lopez-Beltran et al.   EUROPEAN UROLOGY

Natural History of Renal Angiomyolipoma (AML): Most Patients with Large AMLs >4 cm Can Be Offered Active Surveillance as an Initial Management Strategy

(2016) Jaimin R. Bhatt et al.   EUROPEAN UROLOGY

Balanced Translocations Disrupting SMARCB1 Are Hallmark Recurrent Genetic Alterations in Renal Medullary Carcinomas

(2016) Julien Calderaro et al.   EUROPEAN UROLOGY

Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling

(2016) Sumanta K. Pal et al.   EUROPEAN UROLOGY

Everolimus Versus Sunitinib Prospective Evaluation in Metastatic Non–Clear Cell Renal Cell Carcinoma (ESPN): A Randomized Multicenter Phase 2 Trial

(2016) Nizar M. Tannir et al.   EUROPEAN UROLOGY

Genomic Characterization of Renal Cell Carcinoma with Sarcomatoid Dedifferentiation Pinpoints Recurrent Genomic Alterations

(2016) Gabriel G. Malouf et al.   EUROPEAN UROLOGY

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

(2016) Jianing Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase II Trial and Correlative Genomic Analysis of Everolimus Plus Bevacizumab in Advanced Non–Clear Cell Renal Cell Carcinoma

(2016) Martin H. Voss et al.   JOURNAL OF CLINICAL ONCOLOGY

MP71-06 THE IMPACT OF TERT PROMOTER REGION MUTATIONS IN RENAL CELL CARCINOMA

(2016) Jozefina Casuscelli et al.   JOURNAL OF UROLOGY

MP71-07 GENETIC CONCORDANCE RATES OF MATCHED-PAIR RENAL CELL CARCINOMA SAMPLES PROVIDE EVIDENCE OF CLONAL EVOLUTION

(2016) Daniel M. Tennenbaum et al.   JOURNAL OF UROLOGY

Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial

(2016) Andrew J Armstrong et al.   LANCET ONCOLOGY

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma

(2016) Mark Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

(2016) Ying-Bei Chen et al.   Nature Communications

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

(2016) Fengju Chen et al.   Cell Reports

Tumor Mutational Load and Immune Parameters across Metastatic Renal Cell Carcinoma Risk Groups

(2016) G. de Velasco et al.   Cancer Immunology Research

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

(2016) Brandon J. Manley et al.   Translational Cancer Research

Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis

(2015) H. I. Wettersten et al.   CANCER RESEARCH

Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting

(2015) B. Beuselinck et al.   CLINICAL CANCER RESEARCH

Oncologic Surveillance After Surgical Resection for Renal Cell Carcinoma: A Novel Risk-Based Approach

(2015) Suzanne B. Stewart-Merrill et al.   JOURNAL OF CLINICAL ONCOLOGY

A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies

(2015) Brian Rini et al.   LANCET ONCOLOGY

TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype

(2015) A Ari Hakimi et al.   MODERN PATHOLOGY

A river model to map convergent cancer evolution and guide therapy in RCC

(2015) Elizabeth Y. Wei et al.   Nature Reviews Urology

Molecular genetics and clinical features of Birt–Hogg–Dubé syndrome

(2015) Laura S. Schmidt et al.   Nature Reviews Urology

MiT family translocation renal cell carcinoma

(2015) Pedram Argani   SEMINARS IN DIAGNOSTIC PATHOLOGY

Percentage of sarcomatoid component as a prognostic indicator for survival in renal cell carcinoma with sarcomatoid dedifferentiation

(2015) Mehrad Adibi et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

(2015) Michal Kovac et al.   Nature Communications

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

(2015) Shilpy Joshi et al.   Cell Reports

Metastatic Non-Clear Cell Renal Cell Carcinoma: An Evidence Based Review of Current Treatment Strategies

(2015) Alexander Sankin et al.   Frontiers in Oncology

Collecting Duct Carcinoma Versus Renal Medullary Carcinoma

(2014) Mahul B. Amin et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Treatment outcome with mTOR inhibitors for metastatic renal cell carcinoma with nonclear and sarcomatoid histologies

(2014) M. H. Voss et al.   ANNALS OF ONCOLOGY

A novel prognostic model for patients with sarcomatoid renal cell carcinoma

(2014) Ben Y. Zhang et al.   BJU INTERNATIONAL

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

(2014) Caleb F. Davis et al.   CANCER CELL

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy

(2014) M. H. Voss et al.   CLINICAL CANCER RESEARCH

Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

(2014) G. G. Malouf et al.   CLINICAL CANCER RESEARCH

ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma

(2014) Samira A. Brooks et al.   EUROPEAN UROLOGY

Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment

(2014) Fred H. Menko et al.   Familial Cancer

Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma

(2014) Robert J. Motzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of the National Comprehensive Cancer Network and American Urological Association Renal Cell Carcinoma Surveillance Guidelines

(2014) Suzanne B. Stewart et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

(2014) Eric C. Kauffman et al.   Nature Reviews Urology

Cancer of Unknown Primary Site

(2014) Gauri R. Varadhachary et al.   NEW ENGLAND JOURNAL OF MEDICINE

The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling

(2014) Alexander Sankin et al.   Cancer Medicine

Hereditary Kidney Cancer Syndromes

(2013) Naomi B. Haas et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

(2013) John R. Srigley et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Metastatic non-clear cell renal cell carcinoma treated with targeted therapy agents: Characterization of survival outcome and application of the International mRCC Database Consortium criteria

(2013) Nils Kroeger et al.   CANCER

SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer

(2013) Lianjie Li et al.   CANCER CELL

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: A Report by MSKCC and the KIRC TCGA Research Network

(2013) A. A. Hakimi et al.   CLINICAL CANCER RESEARCH

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation

(2013) Payal Kapur et al.   LANCET ONCOLOGY

External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based study

(2013) Daniel YC Heng et al.   LANCET ONCOLOGY

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

A clear picture of renal cell carcinoma

(2013) A Ari Hakimi et al.   NATURE GENETICS

Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations

(2013) Christoph A. Karlo et al.   RADIOLOGY

The Genetic Basis of Kidney Cancer: Implications for Management and Use of Targeted Therapeutic Approaches

(2012) W. Marston Linehan   EUROPEAN UROLOGY

Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma

(2012) A. Ari Hakimi et al.   EUROPEAN UROLOGY

Phase II and Biomarker Study of the Dual MET/VEGFR2 Inhibitor Foretinib in Patients With Papillary Renal Cell Carcinoma

(2012) Toni K. Choueiri et al.   JOURNAL OF CLINICAL ONCOLOGY

Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer

(2012) Christopher J. Ricketts et al.   JOURNAL OF UROLOGY

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sarcomatoid Renal Cell Carcinoma: A Comprehensive Review of the Biology and Current Treatment Strategies

(2012) B. Shuch et al.   ONCOLOGIST

Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia

(2012) Anthony J. Gill   PATHOLOGY

An overview of renal cell cancer: Pathology and genetics

(2012) Holger Moch   SEMINARS IN CANCER BIOLOGY

Differential Diagnosis of Renal Tumors With Papillary Architecture

(2011) Satish K. Tickoo et al.   ADVANCES IN ANATOMIC PATHOLOGY

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Current Pathology Keys of Renal Cell Carcinoma

(2011) Ferran Algaba et al.   EUROPEAN UROLOGY

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

(2011) Guangwu Guo et al.   NATURE GENETICS

Sarcomatoid-variant Renal Cell Carcinoma

(2010) Ana M. Molina et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Unclassified Renal Cell Carcinoma: Impact on Survival Following Nephrectomy

(2010) Paul L. Crispen et al.   UROLOGY

The VHL tumor suppressor and HIF: insights from genetic studies in mice

(2008) P P Kapitsinou et al.   CELL DEATH AND DIFFERENTIATION

Germline SDHB Mutations and Familial Renal Cell Carcinoma

(2008) C. Ricketts et al.   JNCI-Journal of the National Cancer Institute