The immune suppressive function of transforming growth factor-β(TGF-β) in human diseases

Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression

(2014) Tom L. Stephen et al.   IMMUNITY

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

(2014) Mark J. McCarron et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulated Movement of CD4 In and Out of the Immunological Synapse

(2014) H. Kao et al.   JOURNAL OF IMMUNOLOGY

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Truncated Form of TGF- RII, But Not Its Absence, Induces Memory CD8+ T Cell Expansion and Lymphoproliferative Disorder in Mice

(2013) H. Ishigame et al.   JOURNAL OF IMMUNOLOGY

Excessive Th1 responses due to the absence of TGF-  signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis

(2013) H. Ishigame et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  Signaling in Myeloid Cells Is Required for Tumor Metastasis

(2013) Y. Pang et al.   Cancer Discovery

Common mechanisms of autoimmune diseases (the autoimmune tautology)

(2012) Juan-Manuel Anaya   AUTOIMMUNITY REVIEWS

B Effector Cells Activated by a Chimeric Protein Consisting of IL-2 and the Ectodomain of TGF-  Receptor II Induce Potent Antitumor Immunity

(2012) C. Penafuerte et al.   CANCER RESEARCH

Dynamics of TGF-β/Smad signaling

(2012) Zhike Zi et al.   FEBS LETTERS

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

TGF-β puts the brakes on homeostatic proliferation

(2012) Charles D Surh et al.   NATURE IMMUNOLOGY

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

TGF-β Sensitivity Restrains CD8+ T Cell Homeostatic Proliferation by Enforcing Sensitivity to IL-7 and IL-15

(2012) Lisa D. S. Johnson et al.   PLoS One

Requirements of transcription factor Smad-dependent and -independent TGF-  signaling to control discrete T-cell functions

(2012) A.-D. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma

(2011) John M. Kirkwood et al.   CANCER

A phase I study of tasisulam sodium (LY573636 sodium), a novel anticancer compound in patients with refractory solid tumors

(2011) George R. Simon et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

TGF-β in Th17 Cell Development: The Truth Is Out There

(2011) Robin D. Hatton   IMMUNITY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis

(2011) Claire Immediato Daïen et al.   JOINT BONE SPINE

Sex differences and genomics in autoimmune diseases

(2011) Shashi Amur et al.   JOURNAL OF AUTOIMMUNITY

Novel TGF-  Antagonist Inhibits Tumor Growth and Angiogenesis by Inducing IL-2 Receptor-Driven STAT1 Activation

(2011) C. Penafuerte et al.   JOURNAL OF IMMUNOLOGY

Decreased serum levels of TGF-β1 are associated with renal damage in female patients with systemic lupus erythematosus

(2011) T Jin et al.   LUPUS

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

TGF-  downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

(2011) C. A. Crane et al.   NEURO-ONCOLOGY

TGF-β/BMPs: Crucial crossroad in neural autoimmune disorders

(2011) Konstantine I. Voumvourakis et al.   NEUROCHEMISTRY INTERNATIONAL

TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK

(2010) Maren Bakkebø et al.   BMC IMMUNOLOGY

Cellular and molecular basis for the regulation of inflammation by TGF- 

(2010) A. Yoshimura et al.   JOURNAL OF BIOCHEMISTRY

The inhibitory effect of ginsan on TGF-β mediated fibrotic process

(2010) Ji-Yeon Ahn et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Levels of Transforming Growth Factor-  Are Low in Systemic Lupus Erythematosus Patients with Active Disease

(2010) A. BECKER-MEROK et al.   JOURNAL OF RHEUMATOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Quantification of regulatory T cells in peripheral blood of patients with systemic lupus erythematosus

(2010) Mojtaba Habibagahi et al.   RHEUMATOLOGY INTERNATIONAL

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Recent Advances in the Treatment of Systemic Sclerosis

(2009) Vasiliki Kalliopi K. Bournia et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis

(2008) Kazuhisa Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NK cell-activating receptors require PKC-  for sustained signaling, transcriptional activation, and IFN-  secretion

(2008) I. Tassi et al.   BLOOD

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

Systemic Blockade of Transforming Growth Factor-  Signaling Augments the Efficacy of Immunogene Therapy

(2008) S. Kim et al.   CANCER RESEARCH

Transforming Growth Factor  : Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

(2008) L. Yang et al.   CANCER RESEARCH

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

(2008) Masayuki Tsuji et al.   IMMUNITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

(2008) Mark M.W. Chong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

(2008) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

(2008) Takeshi Egawa et al.   NATURE IMMUNOLOGY

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone

(2008) Elke Scandella et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

(2008) Takeshi Egawa et al.   PLoS One

Relief of Preintegration Inhibition and Characterization of Additional Blocks for HIV Replication in Primary Mouse T Cells

(2008) Jing-xin Zhang et al.   PLoS One

Autocrine TGF-β signaling in the pathogenesis of systemic sclerosis

(2007) Hironobu Ihn   JOURNAL OF DERMATOLOGICAL SCIENCE