TREM2 regulates innate immunity in Alzheimer’s disease

Microglia-Mediated Neuroprotection, TREM2 , and Alzheimer’s Disease: Evidence From Optical Imaging

(2018) Carlo Condello et al.   BIOLOGICAL PSYCHIATRY

Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease

(2018) M. Casati et al.   EUROPEAN JOURNAL OF NEUROLOGY

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

(2016) Honghua Zheng et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Vps35-dependent recycling of Trem2 regulates microglial function

(2016) Jie Yin et al.   TRAFFIC

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

(2016) Kristi Henjum et al.   Alzheimers Research & Therapy

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

(2016) Daniel W. Sirkis et al.   Acta Neuropathologica Communications

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

(2015) Sheng Chih Jin et al.   Molecular Neurodegeneration

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

(2015) Teng Jiang et al.   NEUROBIOLOGY OF AGING

TREM2 variants and risk of Alzheimer’s disease: a meta-analysis

(2015) Yanjun Lu et al.   NEUROLOGICAL SCIENCES

TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer’s Disease and Schizophrenia

(2015) Yoko Mori et al.   PLoS One

Evolutionary responses of innate immunity to adaptive immunity

(2014) Amanda E. Ward et al.   INFECTION GENETICS AND EVOLUTION

Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

(2014) Rachel M Bailey et al.   Molecular Neurodegeneration

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Association study ofTREM2polymorphism rs75932628 with late-onset Alzheimer’s disease in Chinese Han population

(2014) Jianfang Ma et al.   NEUROLOGICAL RESEARCH

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

(2014) Zainularifeen Abduljaleel et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 in Alzheimer’s disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled A 42 peptide receptor, in microglial cells

(2008) K. Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY