Understanding the role of steroids in typical and atypical brain development: Advantages of using a “brain in a dish” approach

Human induced pluripotent stem cells for modelling neurodevelopmental disorders

(2017) Karthikeyan Ardhanareeswaran et al.   Nature Reviews Neurology

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAAreceptors at inhibitory synapses

(2017) Jayanta Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rodent Models of Non-classical Progesterone Action Regulating Ovulation

(2017) Melinda A. Mittelman-Smith et al.   Frontiers in Endocrinology

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Potential Role of Oestrogen Modulation in the Treatment of Neurocognitive Deficits in Schizophrenia

(2016) Thomas W. Weickert et al.   CNS DRUGS

Neuroprotection by Estrogen and Progesterone in Traumatic Brain Injury and Spinal Cord Injury

(2016) Evgeni Brotfain et al.   Current Neuropharmacology

Modeling psychiatric disorders with patient-derived iPSCs

(2016) Zhexing Wen et al.   CURRENT OPINION IN NEUROBIOLOGY

On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis

(2016) Francisco Jesús Martinez-Murcia et al.   HUMAN BRAIN MAPPING

Actions of Steroids: New Neurotransmitters

(2016) Lauren M. Rudolph et al.   JOURNAL OF NEUROSCIENCE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1

(2016) Kaneyasu Nishimura et al.   Stem Cell Reports

Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons

(2015) Carole Shum et al.   HORMONES AND BEHAVIOR

Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection

(2015) R. Guennoun et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia

(2015) T W Weickert et al.   MOLECULAR PSYCHIATRY

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

(2015) Jiho Choi et al.   NATURE BIOTECHNOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Mechanisms of stress in the brain

(2015) Bruce S McEwen et al.   NATURE NEUROSCIENCE

The role of progesterone in memory: An overview of three decades

(2015) L.A. Barros et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons

(2015) Katherine J. Sellers et al.   Frontiers in Cellular Neuroscience

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

(2015) Kristen J. Brennand et al.   Stem Cell Reports

Cell death in the central division of the medial preoptic nucleus of male and female lamb fetuses

(2014) Radhika C. Reddy et al.   BRAIN RESEARCH

Human Induced Pluripotent Stem Cells: Now Open to Discovery

(2014) Omer Durak et al.   Cell Stem Cell

GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus

(2014) Obin Kwon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age

(2014) J Kulkarni et al.   MOLECULAR PSYCHIATRY

Glucocorticoids and fetal programming part 1: outcomes

(2014) Vasilis G. Moisiadis et al.   Nature Reviews Endocrinology

Quantitative Analysis of Long-Form Aromatase mRNA in the Male and Female Rat Brain

(2014) Nino Tabatadze et al.   PLoS One

The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

(2014) Negar M Ghahramani et al.   Biology of Sex Differences

Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease

(2013) Meharvan Singh et al.   BRAIN RESEARCH

Progesterone's role in neuroprotection, a review of the evidence

(2013) Eric R. Deutsch et al.   BRAIN RESEARCH

Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons

(2013) Jeng-Rung Chen et al.   Brain Structure & Function

Therapeutic Translation of iPSCs for Treating Neurological Disease

(2013) Diana X. Yu et al.   Cell Stem Cell

Epigenetic Contributions to Hormonally-Mediated Sexual Differentiation of the Brain

(2013) M. M. McCarthy et al.   JOURNAL OF NEUROENDOCRINOLOGY

G-Protein Oestrogen Receptor 1: Trials and Tribulations of a Membrane Oestrogen Receptor

(2013) D. P. Srivastava et al.   JOURNAL OF NEUROENDOCRINOLOGY

Interactive Effects of Dehydroepiandrosterone and Testosterone on Cortical Thickness during Early Brain Development

(2013) T.-V. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Neurosteroids as regenerative agents in the brain: therapeutic implications

(2013) Roberta D. Brinton   Nature Reviews Endocrinology

Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: A key role for progesterone receptors and steroidal modulators of GABAA receptors

(2013) Florencia Labombarda et al.   NEUROPHARMACOLOGY

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

(2013) A. Serio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders

(2013) Graham Cocks et al.   PSYCHOPHARMACOLOGY

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening

(2013) C Boissart et al.   Translational Psychiatry

Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.

(2012) Bruce S. McEwen et al.   BEHAVIORAL NEUROSCIENCE

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse

(2012) Benoit Labonte et al.   BIOLOGICAL PSYCHIATRY

Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area

(2012) Meihua Li et al.   BRAIN RESEARCH

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective

(2012) Gaoyang Liang et al.   CELL RESEARCH

Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on

(2012) P. M. Maki et al.   CLIMACTERIC

Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke

(2012) Ailing Liu et al.   ENDOCRINOLOGY

Characterization, Neurosteroid Binding and Brain Distribution of Human Membrane Progesterone Receptors δ and ϵ (mPRδ and mPRϵ) and mPRδ Involvement in Neurosteroid Inhibition of Apoptosis

(2012) Yefei Pang et al.   ENDOCRINOLOGY

Progesterone and neuroprotection

(2012) Meharvan Singh et al.   HORMONES AND BEHAVIOR

Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain

(2012) M. V. Lombardo et al.   JOURNAL OF NEUROSCIENCE

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

(2012) S.-b. Liu et al.   JOURNAL OF NEUROSCIENCE

Modeling psychiatric disorders at the cellular and network levels

(2012) K J Brennand et al.   MOLECULAR PSYCHIATRY

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism

(2012) Guang Zhe Huang et al.   NEURON

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

(2012) Tie Yuan Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Sex Matters during Adolescence: Testosterone-Related Cortical Thickness Maturation Differs between Boys and Girls

(2012) Jennifer E. Bramen et al.   PLoS One

Effects of Antenatal Glucocorticoid Therapy on Hippocampal Histology of Preterm Infants

(2012) Deodata Tijsseling et al.   PLoS One

Testosterone levels in healthy men are related to amygdala reactivity and memory performance

(2012) Sandra Ackermann et al.   PSYCHONEUROENDOCRINOLOGY

GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus

(2012) C.E. McAllister et al.   PSYCHONEUROENDOCRINOLOGY

Glucocorticoid excess and the developmental origins of disease: Two decades of testing the hypothesis – 2012 Curt Richter Award Winner

(2012) Rebecca M. Reynolds   PSYCHONEUROENDOCRINOLOGY

Gender Development and the Human Brain

(2011) Melissa Hines   Annual Review of Neuroscience

Basic reserach A preliminary study on progesterone antioxidation in promoting learning and memory of young ovariectomized mice

(2011) Lu He et al.   Archives of Medical Science

Allopregnanolone prevents memory impairment: Effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase

(2011) Carla Escudero et al.   BRAIN RESEARCH BULLETIN

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

Constitutive heterochromatin reorganization during somatic cell reprogramming

(2011) Eden Fussner et al.   EMBO JOURNAL

Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders

(2011) Ai-Min Bao et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Reframing sexual differentiation of the brain

(2011) Margaret M McCarthy et al.   NATURE NEUROSCIENCE

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Low dose Estrogen Prevents Neuronal Degeneration and Microglial Reactivity in an Acute Model of Spinal Cord Injury: Effect of Dosing, Route of Administration, and Therapy Delay

(2011) Supriti Samantaray et al.   NEUROCHEMICAL RESEARCH

Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism

(2011) Michael V. Lombardo et al.   NEUROIMAGE

Estradiol synthesis within the human brain

(2011) I. Azcoitia et al.   NEUROSCIENCE

Stress effects on memory: An update and integration

(2011) Lars Schwabe et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats

(2011) Sebastián Casas et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio

(2011) J. van Honk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identity, Fate and Potential of Cells Grown as Neurospheres: Species Matters

(2011) Carolin Steffenhagen et al.   Stem Cell Reviews and Reports

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells

(2011) Christopher J. Bissonnette et al.   STEM CELLS

Neuroprotective actions of estradiol revisited

(2011) Iñigo Azcoitia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Global epigenetic changes during somatic cell reprogramming to iPS cells

(2011) Anna Mattout et al.   Journal of Molecular Cell Biology

The von economo neurons in apes and humans

(2010) John M. Allman et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Z-Bisdehydrodoisynolic acid (Z-BDDA): An estrogenic seco-steroid that enhances behavioral recovery following moderate fluid percussion brain injury in male rats

(2010) Steven L. Neese et al.   BRAIN RESEARCH

From stem cells to neural networks: recent advances and perspectives for neurodevelopmental disorders

(2010) NICOLAS GASPARD et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Morning Cortisol Levels and Cognitive Abilities in People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study

(2010) R. M. Reynolds et al.   DIABETES CARE

Sex Differences in Epigenetic Regulation of the Estrogen Receptor-α Promoter within the Developing Preoptic Area

(2010) Joseph R. Kurian et al.   ENDOCRINOLOGY

Sex differences in histone modifications in the neonatal mouse brain

(2010) Houng-Wei Tsai et al.   Epigenetics

Acute estrogen treatment facilitates recognition memory consolidation and alters monoamine levels in memory-related brain areas

(2010) T. Inagaki et al.   HORMONES AND BEHAVIOR

Renewed focus on the developing human neocortex

(2010) Gavin Clowry et al.   JOURNAL OF ANATOMY

Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice

(2010) Cheryl A. Frye et al.   NEUROSCIENCE LETTERS

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

(2010) G. E. Gillies et al.   PHARMACOLOGICAL REVIEWS

Association of Increased Prenatal Estrogen With Risk Factors for Schizophrenia

(2010) James S. Brown   SCHIZOPHRENIA BULLETIN

Sex-related variation in human behavior and the brain

(2010) Melissa Hines   TRENDS IN COGNITIVE SCIENCES

Sex differences in brain epigenetics

(2010) Yannick Menger et al.   Epigenomics

Frontiers proposal. National Institute on Aging “bench to bedside: estrogen as a case study”

(2009) Sanjay Asthana et al.   AGE

Modulation of synaptic plasticity by brain estrogen in the hippocampus

(2009) Hideo Mukai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Generation of induced pluripotent stem cells from human blood

(2009) Y.-H. Loh et al.   BLOOD

Epigenetic Regulation of Estrogen Receptor α Gene Expression in the Mouse Cortex during Early Postnatal Development

(2009) Jenne M. Westberry et al.   ENDOCRINOLOGY

Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord

(2009) N. G. Forger   JOURNAL OF NEUROENDOCRINOLOGY

Gonadal Steroid Action and Brain Sex Differentiation in the Rat

(2009) Y. Sakuma   JOURNAL OF NEUROENDOCRINOLOGY

Sex Differences and the Roles of Sex Steroids in Apoptosis of Sexually Dimorphic Nuclei of the Preoptic Area in Postnatal Rats

(2009) S. Tsukahara   JOURNAL OF NEUROENDOCRINOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Differentiation of human oligodendrocytes from pluripotent stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

Differentiation of spinal motor neurons from pluripotent human stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

(2009) Shawn F. Sorrells et al.   NEURON

Regulation of Neural Specification from Human Embryonic Stem Cells by BMP and FGF

(2009) Timothy M. LaVaute et al.   STEM CELLS

A role for the spine apparatus in LTP and spatial learning

(2008) Peter Jedlicka et al.   BEHAVIOURAL BRAIN RESEARCH

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Androgen action in the brain and spinal cord for the regulation of male sexual behaviors

(2008) K MATSUDA et al.   CURRENT OPINION IN PHARMACOLOGY

Stress Impairs Reconsolidation of Drug Memory via Glucocorticoid Receptors in the Basolateral Amygdala

(2008) X.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

(2008) Trond Aasen et al.   NATURE BIOTECHNOLOGY

The adult human brain in preclinical drug development

(2008) Mike Dragunow   NATURE REVIEWS DRUG DISCOVERY

Effects of pre-learning stress on memory for neutral, positive and negative words: Different roles of cortisol and autonomic arousal

(2008) Lars Schwabe et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus

(2008) H. Xu et al.   NEUROSCIENCE

Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats

(2008) Dafne García-Chávez et al.   NEUROSCIENCE LETTERS

Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats

(2008) Shinji Tsukahara et al.   NEUROSCIENCE LETTERS

Estradiol and the Developing Brain

(2008) MARGARET M. McCARTHY   PHYSIOLOGICAL REVIEWS

True or false? Memory is differentially affected by stress-induced cortisol elevations and sympathetic activity at consolidation and retrieval

(2008) Tom Smeets et al.   PSYCHONEUROENDOCRINOLOGY

Regenerative potential of allopregnanolone

(2007) Jun Ming Wang et al.   BRAIN RESEARCH REVIEWS

Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids

(2007) Amita Kapoor et al.   BRAIN RESEARCH REVIEWS

Non-genomic actions of androgens

(2007) C.D. Foradori et al.   FRONTIERS IN NEUROENDOCRINOLOGY