Insulin-like growth factors: actions on the skeleton

Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses

(2017) Jean-Christophe François et al.   ENDOCRINOLOGY

Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms

(2017) Peter Rotwein   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF-1 Receptor Expression on Circulating Osteoblast Progenitor Cells Predicts Tissue-Based Bone Formation Rate and Response to Teriparatide in Premenopausal Women With Idiopathic Osteoporosis

(2017) Adi Cohen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass

(2017) Zhongbo Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice

(2017) Joohyun Lim et al.   Bone Research

Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice

(2016) Nicole M. Ashpole et al.   AGE

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

(2016) A. Dauber et al.   EMBO Molecular Medicine

DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH

(2016) Zhongbo Liu et al.   FASEB JOURNAL

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies

(2016) Zhongbo Liu et al.   GROWTH HORMONE & IGF RESEARCH

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models

(2016) Shoshana Yakar et al.   GROWTH HORMONE & IGF RESEARCH

The Relationship Between Calciotropic Hormones, IGF-1, and Bone Mass Across Pubertal Stages

(2016) Maria Matar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency

(2016) María T. Muñoz-Calvo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone

(2015) Kari B. Clifton et al.   BONE

Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth

(2015) Shufang Wu et al.   ENDOCRINOLOGY

IGF-1 Receptor Insufficiency Leads to Age-Dependent Attenuation of Osteoblast Differentiation

(2015) Lee-Chuan C. Yeh et al.   ENDOCRINOLOGY

Parathyroid Hormone Levels in Healthy Children and Adolescents

(2015) Stefano Stagi et al.   Hormone Research in Paediatrics

A New HomozygousIGF1RVariant Defines a Clinically Recognizable Incomplete Dominant form of SHORT Syndrome

(2015) Paolo Prontera et al.   HUMAN MUTATION

PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

(2015) Emel Esen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development

(2015) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts

(2015) Muriel Babey et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

(2015) Nicole M Ashpole et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Mineral Accrual Is Associated With Parathyroid Hormone and 1,25-Dihydroxyvitamin D Levels in Children and Adolescents

(2015) Mark D. DeBoer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study

(2015) Emily Krantz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly

(2015) Cristina Capatina et al.   JOURNAL OF ENDOCRINOLOGY

Paternally Inherited IGF2 Mutation and Growth Restriction

(2015) Matthias Begemann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

(2015) Yu Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ephrin B2/EphB4 Mediates the Actions of IGF-I Signaling in Regulating Endochondral Bone Formation

(2014) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osx-Cre Targets Multiple Cell Types besides Osteoblast Lineage in Postnatal Mice

(2014) Jianquan Chen et al.   PLoS One

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity

(2013) K.-H. William Lau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Serum IGF-1 Is Insufficient to Restore Skeletal Size in the Total Absence of the Growth Hormone Receptor

(2013) Yingjie Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A Novel Deletion ofIGF1in a Patient With Idiopathic Short Stature Provides Insight IntoIGF1Haploinsufficiency

(2013) Lara Batey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An experimental model of partial insulin-like growth factor-1 deficiency in mice

(2013) I. Castilla-Cortazar et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading

(2012) Takuo Kubota et al.   ACTA ASTRONAUTICA

Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice

(2012) Matilda H.-C. Sheng et al.   BONE

Homozygous mutation of the IGF1 receptor gene in a patient with severe pre- and postnatal growth failure and congenital malformations

(2012) Marie-Hélène Gannagé-Yared et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Identification of a Novel HeterozygousIGF1Splicing Mutation in a Large Kindred with Familial Short Stature

(2012) John S. Fuqua et al.   Hormone Research in Paediatrics

Vertebral Fracture Assessment in Acromegaly

(2012) Miguel Madeira et al.   JOURNAL OF CLINICAL DENSITOMETRY

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

(2012) Emmanuelle Renard et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

IGF-1 and BRCA1 signalling pathways in familial cancer

(2012) Haim Werner et al.   LANCET ONCOLOGY

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression

(2011) Sebastien Elis et al.   AGING CELL

IGF1R mutations as cause of SGA

(2011) J. Klammt et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Selective osteoblast overexpression of IGF-I in mice prevents low protein-induced deterioration of bone strength and material level properties

(2011) Tara C. Brennan-Speranza et al.   BONE

Unbound (bioavailable) IGF1 enhances somatic growth

(2011) S. Elis et al.   Disease Models & Mechanisms

High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly

(2011) M J E Wassenaar et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice

(2011) Emily J. Mason et al.   GROWTH HORMONE & IGF RESEARCH

IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway

(2011) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I

(2011) Mohamed El Kholy et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Liver-Derived IGF-I Contributes to GH-Dependent Increases in Lean Mass and Bone Mineral Density in Mice with Comparable Levels of Circulating GH

(2011) Sarah M. Nordstrom et al.   MOLECULAR ENDOCRINOLOGY

Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer

(2011) H Werner   ONCOGENE

Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner

(2011) Hayden-William Courtland et al.   PLoS One

Immobilization and bone structure in humans

(2010) Harri Sievänen   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification of IGFBP-3 fragments generated by KLK2 and prevention of fragmentation by KLK2-inhibiting peptides

(2010) Can Hekim et al.   BIOLOGICAL CHEMISTRY

Insulin-Like Growth Factor-I Treatment in Primary Growth Hormone Insensitivity: Effect of Recombinant Human IGF-I (rhIGF-I) and rhIGF-I/rhIGF-Binding Protein-3 Complex

(2010) P. Tonella et al.   Hormone Research in Paediatrics

Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women

(2010) Laura J. Ghiron et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal unloading induces resistance to insulin-like growth factor I

(2010) Daniel D. Bikle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age

(2010) J. Pfeilschifter et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation

(2010) Liang Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sex-specific regulation of body size and bone slenderness by the acid labile subunit

(2010) Hayden-William Courtland et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Short Stature Associated with a Novel Heterozygous Mutation in theInsulin-Like Growth Factor 1Gene

(2010) H. A. van Duyvenvoorde et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Early activation of the β-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase

(2009) Ana Santos et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Rapid Signal Transducer and Activator of Transcription-5 Phosphorylation in the Resting Cells of the Growth Plate and in the Liver by Growth Hormone and Feeding

(2009) Evelien F. Gevers et al.   ENDOCRINOLOGY

Human Acid-Labile Subunit Deficiency: Clinical, Endocrine and Metabolic Consequences

(2009) Horacio M. Domené et al.   HORMONE RESEARCH

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parallel-plate fluid flow systems for bone cell stimulation

(2009) Carmen Huesa et al.   JOURNAL OF BIOMECHANICS

Serum IGF-1 Determines Skeletal Strength by Regulating Subperiosteal Expansion and Trait Interactions

(2009) Shoshana Yakar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1)

(2009) J Christopher Fritton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated withIGF1Mutation Demonstrates Its Critical Role in Growth and Brain Development

(2009) Irène Netchine et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dihydrotestosterone is a determinant of calcaneal bone mineral density in men

(2009) Ramachandran Ilangovan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

IGF2 modulates the microenvironment for osteoclastogenesis

(2008) Kimihisa Nakao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gender-Specific Changes in Bone Turnover and Skeletal Architecture inIgfbp-2-Null Mice

(2008) V. E. DeMambro et al.   ENDOCRINOLOGY

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

(2008) Shoshana Yakar et al.   FASEB JOURNAL

Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 Gene

(2008) R. Murphy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prevalence of Vertebral Fractures in Men with Acromegaly

(2008) Gherardo Mazziotti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activityin Vivo

(2008) Yun Ning et al.   MOLECULAR ENDOCRINOLOGY