Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

(2015) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

The Insulin-Like Growth Factor System in Bone

(2012) Masanobu Kawai et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Gli1 Protein Participates in Hedgehog-mediated Specification of Osteoblast Lineage during Endochondral Ossification

(2012) Hironori Hojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway

(2012) Yu Shi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

(2012) P. Dalle Pezze et al.   Science Signaling

Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts

(2011) Shengyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner

(2008) W. Yu et al.   DEVELOPMENT