Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

(2016) Sofiya Milman et al.   Cell Metabolism

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

(2016) C Daniel De Magalhaes Filho et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

(2016) Brian T. O’Neill et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice

(2016) Christopher J. Romero et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

(2016) Vikram Narayan et al.   Cell Systems

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging

(2015) Zayna Chaker et al.   AGING CELL

Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I

(2015) Adam B. Salmon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans

(2015) Christian Sell   MOLECULAR ENDOCRINOLOGY

Minireview: Were the IGF Signaling Inhibitors All Bad?

(2015) Heather Beckwith et al.   MOLECULAR ENDOCRINOLOGY

Can aging be 'drugged'?

(2015) Celine E Riera et al.   NATURE MEDICINE

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

(2015) Ryan R. White et al.   Nature Communications

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis

(2015) Brian T. O’Neill et al.   Cell Reports

Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice

(2014) Icíar Paula López et al.   TRANSGENIC RESEARCH

Reductions in serum IGF-1 during aging impair health span

(2013) Zhenwei Gong et al.   AGING CELL

Longevity effect of IGF-1R+/−mutation depends on genetic background-specific receptor activation

(2013) Jie Xu et al.   AGING CELL

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone

(2013) Johanna G. Miquet et al.   CELL CYCLE

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

(2013) Leonard Girnita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Carbohydrate Sensitive Rat as a Model of Obesity

(2013) Nachiket A. Nadkarni et al.   PLoS One

IGF-1R as an anti-cancer target--trials and tribulations

(2013) Helen X. Chen et al.   Chinese Journal of Cancer

Indirect calorimetry in laboratory mice and rats: principles, practical considerations, interpretation and perspectives

(2012) Patrick C. Even et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung Morphogenesis

(2012) Ralph Epaud et al.   PLoS One

IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway

(2011) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prolonged exposure to GH impairs insulin signaling in the heart

(2011) J G Miquet et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner

(2011) Hayden-William Courtland et al.   PLoS One

Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

(2011) Andreas F. Kolb et al.   PLoS One

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

(2010) Mahendra D. Mavalli et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples

(2010) J. Xu et al.   JOURNAL OF ENDOCRINOLOGY

Assessment of spatial memory in mice

(2010) Sunita Sharma et al.   LIFE SCIENCES

Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neurodegeneration

(2010) Sunita Sharma et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model

(2010) Christopher J. Romero et al.   MOLECULAR ENDOCRINOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Spatial memory: Theoretical basis and comparative review on experimental methods in rodents

(2009) Carrillo-Mora Paul et al.   BEHAVIOURAL BRAIN RESEARCH

Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma

(2009) Paul Haluska et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Biological effects of growth hormone on carbohydrate and lipid metabolism

(2009) Archana Vijayakumar et al.   GROWTH HORMONE & IGF RESEARCH

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

(2009) A Gualberto et al.   ONCOGENE

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth

(2008) N. Kloting et al.   DIABETES

Lymphoid neogenesis and immune infiltration in aged liver

(2008) Pallavi Singh et al.   HEPATOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY