Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

NMDA and kainate receptor expression, long-term potentiation, and neurogenesis in the hippocampus of long-lived Ames dwarf mice

(2011) Sunita Sharma et al.   AGE

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

(2011) Shi Zhang et al.   Journal of Neuroinflammation

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

(2011) C Lee et al.   ONCOGENE

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain

(2011) Edoardo Parrella et al.   TheScientificWorldJOURNAL

Continuous and Cyclic Progesterone Differentially Interact with Estradiol in the Regulation of Alzheimer-Like Pathology in Female 3×Transgenic-Alzheimer’s Disease Mice

(2010) Jenna C. Carroll et al.   ENDOCRINOLOGY

Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neurodegeneration

(2010) Sunita Sharma et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity

(2009) M. M. Masternak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice

(2009) Peter R. Mouton et al.   NEUROSCIENCE LETTERS

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

(2008) Luigi Fontana et al.   AGING CELL

Validation of a 2-day water maze protocol in mice

(2008) Maria Gulinello et al.   BEHAVIOURAL BRAIN RESEARCH

Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity

(2008) Ángela Fontán-Lozano et al.   MOLECULAR NEUROBIOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit

(2007) David L. Hwang et al.   GROWTH HORMONE & IGF RESEARCH

Hippocampus of Ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels

(2007) Matthew Schrag et al.   HIPPOCAMPUS

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

(2007) Pu Wu et al.   NEUROBIOLOGY OF AGING