Article
Biochemistry & Molecular Biology
Yue Liang, Ping Wang, Yueyang Shi, Bihong Cui, Jinlai Meng
Summary: This study revealed that MEG3 regulates trophoblast function and inflammation through the Wnt/beta-Catenin/NLRP3 axis, providing new insights into the pathogenesis of preeclampsia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Obstetrics & Gynecology
Yi Zhang, Yuxin Ran, Yunpeng Ma, Hua Huang, Ying Chen, Hongbo Qi
Summary: PE is a life-threatening pregnancy complication associated with diminished trophoblast migration and invasion. Elevated levels of SFRP5 were found in the serum of PE patients, while SFRP5 expression was not detected in placental tissues. Furthermore, SFRP5 inhibits trophoblast migration and invasion potentially via the inhibition of the Wnt/beta-catenin signaling pathway.
REPRODUCTIVE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xueqin Jia, Shiying Yang, Xia Wang, Jianbing Ruan, Wenhua Huang
Summary: This study identified the impact of HOXB3 in preeclampsia and found that its overexpression can promote trophoblast cell proliferation and migration by regulating the Notch1 and β-catenin pathways. The study also showed that suppressing the Wnt/β-catenin pathway can alleviate the effects of HOXB3. These findings provide a novel approach for preeclampsia therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Yan Li, Bao-xiang Xing, Yi-hao Wang, Sha Yu, Han Zhao, Qing-qing Lv, Cai-xia Lu
Summary: The study found that CTHRC1 expression levels were lower in placental tissues of preeclampsia patients compared to women with normal pregnancies. Down-regulation of CTHRC1 impairs trophoblast cell proliferation, migration, and invasion abilities. CTHRC1 may promote trophoblast cell migration and invasion through the Wnt/beta-catenin signaling pathway.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Guo-Dong Han, Yuan Sun, Hong-Xia Hui, Ming-Yue Tao, Yang-Qing Liu, Jing Zhu
Summary: Our research aimed to explore the potential involvement of miR-1224 in the progression of gastric cancer (GC). We found that miR-1224 was lowly expressed in GC specimens and cell lines, and its overexpression inhibited cell proliferation, migration, and invasion in GC cells. Additionally, SATB1 was identified as a direct target of miR-1224 in GC, and the expression of beta-catenin and c-myc was significantly inhibited in miR-1224-overexpression cells. Our findings suggest that miR-1224 has the potential to be a therapeutic target and novel biomarker for GC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu'uhevaha J. Kaitu'u-Lino, Kenji Onda, Natalie J. Hannan
Summary: The study demonstrated that both esomeprazole MH and MTH could reduce key factors associated with preeclampsia, but esomeprazole MH was more efficacious in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Chenrui Cao, Yimin Dai, Zhiyin Wang, Guangfeng Zhao, Honglei Duan, Xiangyu Zhu, Jingmei Wang, Mingming Zheng, Qiao Weng, Limin Wang, Wenjing Gou, Haili Zhang, Chanjuan Li, Dan Liu, Yali Hu
Summary: This study investigates the expression and function of Junctional adhesion molecule-C (JAM-C) in normal pregnancy and preeclampsia (PE). The results demonstrate that JAM-C plays a role in normal placentation and the upregulation of JAM-C contributes to the development of PE.
Article
Immunology
Zhongmei Yang, Xiaoyan Jia, Qinyin Deng, Mengdie Luo, Yan Hou, Jun Yue, Jie Mei, Zhao Wu, Nan Shan
Summary: This study investigated the mechanistic basis of hUCMSCs-derived extracellular vesicles loaded with TFCP2 in the activities of EVT cells in preeclampsia. It was found that hUCMSCs-EVs overexpressing TFCP2 activated the Wnt/beta-catenin pathway, promoting the proliferative, migratory, and invasive potential of EVT cells. These findings suggest that hUCMSCs-EVs overexpressing TFCP2 may be instrumental for the therapeutic targeting and clinical management of preeclampsia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Biochemistry & Molecular Biology
Liu Li, Shuo Wang, Ming Wang, Guoqing Qi, Hongliang Zhao
Summary: This study found that USP5 was lowly expressed in the placentas of PE patients and H/R-induced trophoblast cells. Overexpression of USP5 promoted trophoblast cell proliferation and up-regulated the Wnt/beta-catenin signaling pathway. Conversely, silence of USP5 resulted in opposite effects.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lijun Huang, Zhaowei Tu, Liudan Wei, Wei Sun, Yifan Wang, Shilei Bi, Fang He, Lili Du, Jingsi Chen, Julia Kzhyshkowska, Haibin Wang, Dunjin Chen, Shuang Zhang
Summary: The interaction between trophoblasts, stroma cells, and immune cells at the maternal-fetal interface is crucial for successful pregnancy outcomes. However, efficient experimental models are lacking to investigate this complex interplay. To address this challenge, a reliable method for generating placenta villi organoids (PVOs) from different pregnancies is developed, enabling the analysis of cellular components and genetic alterations. PVOs derived from patients with preeclampsia exhibit specific pathological features. The development of PVOs can provide insights into placenta development and placenta-related diseases.
Article
Biotechnology & Applied Microbiology
Liu Jinyu, Wang Shuying, Zheng Panchan, Chen Dan, Chen Chao, Yang Xingyu, Cheng Weiwei
Summary: The expression of BST2 and MMP2 is significantly downregulated in preeclampsia. Overexpression of BST2 can upregulate MMP2 expression and enhance the migration and invasion capacity of trophoblast cells. Knockdown of BST2 or MMP2 has opposite effects. These results suggest that the downregulation of BST2 may play a role in the pathogenesis of preeclampsia.
Article
Biochemistry & Molecular Biology
Kaiyu Kubota, Khursheed Iqbal, Michael J. Soares
Summary: The study identified SATB1 downstream targets and found that TDH plays a role in trophoblast cell development. The dysregulation of TDH affected cell proliferation, gene expression, and colony size in TS cells. These findings demonstrate the importance of regulatory pathways in controlling TS cell dynamics and ultimately impacting pregnancy outcomes and postnatal health.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biochemistry & Molecular Biology
Hamid-Reza Kohan-Ghadr, Brooke Armistead, Mikaela Berg, Sascha Drewlo
Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)