Article
Obstetrics & Gynecology
Yi Zhang, Yuxin Ran, Yunpeng Ma, Hua Huang, Ying Chen, Hongbo Qi
Summary: PE is a life-threatening pregnancy complication associated with diminished trophoblast migration and invasion. Elevated levels of SFRP5 were found in the serum of PE patients, while SFRP5 expression was not detected in placental tissues. Furthermore, SFRP5 inhibits trophoblast migration and invasion potentially via the inhibition of the Wnt/beta-catenin signaling pathway.
REPRODUCTIVE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xueqin Jia, Shiying Yang, Xia Wang, Jianbing Ruan, Wenhua Huang
Summary: This study identified the impact of HOXB3 in preeclampsia and found that its overexpression can promote trophoblast cell proliferation and migration by regulating the Notch1 and β-catenin pathways. The study also showed that suppressing the Wnt/β-catenin pathway can alleviate the effects of HOXB3. These findings provide a novel approach for preeclampsia therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yue Liang, Ping Wang, Yueyang Shi, Bihong Cui, Jinlai Meng
Summary: This study revealed that MEG3 regulates trophoblast function and inflammation through the Wnt/beta-Catenin/NLRP3 axis, providing new insights into the pathogenesis of preeclampsia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Zhongmei Yang, Xiaoyan Jia, Qinyin Deng, Mengdie Luo, Yan Hou, Jun Yue, Jie Mei, Zhao Wu, Nan Shan
Summary: This study investigated the mechanistic basis of hUCMSCs-derived extracellular vesicles loaded with TFCP2 in the activities of EVT cells in preeclampsia. It was found that hUCMSCs-EVs overexpressing TFCP2 activated the Wnt/beta-catenin pathway, promoting the proliferative, migratory, and invasive potential of EVT cells. These findings suggest that hUCMSCs-EVs overexpressing TFCP2 may be instrumental for the therapeutic targeting and clinical management of preeclampsia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liu Li, Shuo Wang, Ming Wang, Guoqing Qi, Hongliang Zhao
Summary: This study found that USP5 was lowly expressed in the placentas of PE patients and H/R-induced trophoblast cells. Overexpression of USP5 promoted trophoblast cell proliferation and up-regulated the Wnt/beta-catenin signaling pathway. Conversely, silence of USP5 resulted in opposite effects.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Changcun Zhang, Qiping Han, E. Luoji
Summary: The involvement and potential mechanism of action of ubiquitin-specific peptidase 22 (USP22) in the pathogenesis of preeclampsia (PE) were investigated. USP22 expression was significantly reduced in PE placental tissue compared to control tissues. USP22 promoted trophoblast cell proliferation, increased cell motility, and enhanced angiogenesis capacity. USP22 regulated cell proliferation and migration through the Wnt/3-catenin pathway.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yong Chen, Lanning Jia, Ke Zhao, Zuoyu Chen, Yue Han, Xianghui He
Summary: Anaplastic thyroid carcinoma (ATC) is an aggressive tumor with limited treatment options. This study found that collagen triple helix repeat containing-1 (CTHRC1) was upregulated in ATC tissues and correlated with poor survival in thyroid carcinoma patients. Knockdown of CTHRC1 decreased ATC cell proliferation, migration, and invasion abilities by suppressing the Wnt/β-catenin pathway and epithelial-mesenchymal transition (EMT) at the protein level.
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Chenrui Cao, Yimin Dai, Zhiyin Wang, Guangfeng Zhao, Honglei Duan, Xiangyu Zhu, Jingmei Wang, Mingming Zheng, Qiao Weng, Limin Wang, Wenjing Gou, Haili Zhang, Chanjuan Li, Dan Liu, Yali Hu
Summary: This study investigates the expression and function of Junctional adhesion molecule-C (JAM-C) in normal pregnancy and preeclampsia (PE). The results demonstrate that JAM-C plays a role in normal placentation and the upregulation of JAM-C contributes to the development of PE.
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxin Chen, Yingying Meng, Yanhong Yu, Wen Li, Yongmei Shen, Shanshan Li, Ying Chang, Wei Sun
Summary: This study found that the level of LMO2 was decreased in both cytotrophoblast and interstitial extravillous trophoblast in human preeclampsia placentas, and its functions differed in promoting cell migration and proliferation in different trophoblast subtypes. The findings suggest LMO2 as a potential novel target for prediction, prevention, and treatment of preeclampsia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)