Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta

PlGF (Placental Growth Factor) Testing in Clinical Practice: Evidence From a Canadian Tertiary Maternity Referral Center

(2021) Kelsey McLaughlin et al.   HYPERTENSION

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

(2020) Brooke Armistead et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Placental regulation of energy homeostasis during human pregnancy

(2020) Brooke Armistead et al.   ENDOCRINOLOGY

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

(2019) Elizabeth A. Phipps et al.   Nature Reviews Nephrology

Preeclampsia

(2019) Sarosh Rana et al.   CIRCULATION RESEARCH

Pharmacological activation of peroxisome proliferator-activated receptor gamma (PPAR-γ) protects against hypoxia-associated fetal growth restriction

(2019) Sydney L. Lane et al.   FASEB JOURNAL

Human placenta and trophoblast development: key molecular mechanisms and model systems

(2019) Martin Knöfler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Placental Basis of Fetal Growth Restriction

(2019) Rebecca L. Zur et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Oxidative Stress in Preeclampsia and Placental Diseases

(2018) Rajaa Aouache et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

(2018) Hakimeh Mohammadi et al.   Scientific Reports

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

(2018) Richard Brust et al.   Nature Communications

Trophoblast lineage specification, differentiation and their regulation by oxygen tension

(2017) Ching-Wen Chang et al.   JOURNAL OF ENDOCRINOLOGY

Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

(2017) Ruth Ganss   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ANGPTL4 mediates the protective role of PPARγ activators in the pathogenesis of preeclampsia

(2017) Lei Liu et al.   Cell Death & Disease

FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia

(2017) Ami Ashar-Patel et al.   Scientific Reports

Circulating Antiangiogenic Factors and Myocardial Dysfunction in Hypertensive Disorders of PregnancyNovelty and Significance

(2016) Sajid Shahul et al.   HYPERTENSION

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

(2016) Harald Zeisler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia

(2016) Harald Zeisler et al.   OBSTETRICS AND GYNECOLOGY

HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models

(2015) Ivan V. Kulakovskiy et al.   NUCLEIC ACIDS RESEARCH

Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications

(2014) Xiujun Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

The balancing act – PPAR-γ’s roles at the maternal-fetal interface

(2014) Leena Kadam et al.   Systems Biology in Reproductive Medicine

PPAR-γRegulates Trophoblast Differentiation in the BeWo Cell Model

(2014) Khrystyna Levytska et al.   PPAR Research

Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study

(2013) JE Myers et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Inhibition of peroxisome proliferator-activated receptor γ: a potential link between chronic maternal hypoxia and impaired fetal growth

(2013) Colleen G. Julian et al.   FASEB JOURNAL

Detecting endogenous SUMO targets in mammalian cells and tissues

(2013) Janina Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypoxia and Trophoblast Differentiation: A Key Role for PPARγ

(2013) Veronique Tache et al.   STEM CELLS AND DEVELOPMENT

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling

(2013) Martin Knöfler et al.   Frontiers in Genetics

High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples

(2012) Richard E. Leach et al.   HUMAN REPRODUCTION

Effects of Reduced Gcm1 Expression on Trophoblast Morphology, Fetoplacental Vascularity, and Pregnancy Outcomes in Mice

(2012) Shannon A. Bainbridge et al.   HYPERTENSION

Transcriptionally Active Syncytial Aggregates in the Maternal Circulation May Contribute to Circulating Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

(2012) Augustine Rajakumar et al.   HYPERTENSION

Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis

(2012) Matthias Ruebner et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Revisiting the housekeeping genes of human placental development and insufficiency syndromes

(2012) S. Drewlo et al.   PLACENTA

Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity

(2011) Véronique Taché et al.   HUMAN PATHOLOGY

Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth

(2011) Jiska Jebbink et al.   HYPERTENSION

Peroxisome Proliferator-Activated Receptor-γ as a Potential Therapeutic Target in the Treatment of Preeclampsia

(2011) Fergus P. McCarthy et al.   HYPERTENSION

Evidence Implicating Peroxisome Proliferator-Activated Receptor-γ in the Pathogenesis of Preeclampsia

(2011) Fergus P. McCarthy et al.   HYPERTENSION

Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling

(2011) S. DREWLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: Gestational diabetes mellitus, intrauterine growth restriction and preeclampsia

(2010) S.J. Holdsworth-Carson et al.   PLACENTA

Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast

(2009) D Baczyk et al.   CELL DEATH AND DIFFERENTIATION

A Recently Evolved Novel Trophoblast-Enriched Secreted Form of fms-Like Tyrosine Kinase-1 Variant Is Up-Regulated in Hypoxia and Preeclampsia

(2009) Christie P. Thomas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PPARγ Regulates Trophoblast Proliferation and Promotes Labyrinthine Trilineage Differentiation

(2009) Mana M. Parast et al.   PLoS One

Glial Cell Missing 1 Regulates Placental Growth Factor (PGF) Gene Transcription in Human Trophoblast1

(2007) Miao Chang et al.   BIOLOGY OF REPRODUCTION