Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Reduced VDAC1 Protects Against Alzheimer's Disease, Mitochondria, and Synaptic Deficiencies

(2018) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

(2017) Michael V. Airola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

(2017) Doris Höglinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes

(2017) David P. Hoogerheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch

(2017) Eduardo N. Maldonado   Frontiers in Oncology

Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

(2016) T. Walter et al.   CHEMICAL COMMUNICATIONS

Ceramide channel: Structural basis for selective membrane targeting

(2016) Meenu N. Perera et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer';s Disease

(2016) Sankha Shubhra Chakrabarti et al.   Current Alzheimer Research

A Central Role for ATP Signalling in Glial Interactions in the CNS

(2016) Andrea Rivera et al.   CURRENT DRUG TARGETS

Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β

(2016) Elizabeth Roundhill et al.   FASEB JOURNAL

Novel insights into role of miR-320a-VDAC1 axis in astrocyte-mediated neuronal damage in neuroAIDS

(2016) Mahar Fatima et al.   GLIA

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Alterations in voltage-sensing of the mitochondrial permeability transition pore in ANT1-deficient cells

(2016) Judit Doczi et al.   Scientific Reports

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner

(2016) Yanfang Rui et al.   Molecular Brain

Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain

(2016) Kazuki Harada et al.   Frontiers in Neuroscience

A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction

(2016) Michael A. Kennedy et al.   Scientific Reports

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions

(2015) Per Haberkant et al.   ACS Chemical Biology

Ceramide induced mitophagy and tumor suppression

(2015) Mohammed Dany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3

(2015) Ji Na Kong et al.   MOLECULAR BIOLOGY OF THE CELL

Fat & fabulous: Bifunctional lipids in the spotlight

(2014) Per Haberkant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

VDAC phosphorylation, a lipid sensor influencing the cell fate

(2014) Cécile Martel et al.   MITOCHONDRION

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

(2014) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

(2014) A. E. Prota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo

(2014) Tasleem Arif et al.   Molecular Therapy-Nucleic Acids

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes

(2013) Pallabi Sarkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

In Vivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids

(2013) Per Haberkant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ATP Transport through VDAC and the VDAC–Tubulin Complex Probed by Equilibrium and Nonequilibrium MD Simulations

(2013) Sergei Yu. Noskov et al.   BIOCHEMISTRY

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

(2013) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motility of astrocytic mitochondria is arrested by Ca2+-dependent interaction between mitochondria and actin filaments

(2012) Elena Kremneva et al.   CELL CALCIUM

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Lipid Composition Regulates Tubulin Interaction with Mitochondrial Voltage-dependent Anion Channel

(2012) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of an apical ceramide-enriched compartment regulating ciliogenesis

(2012) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

(2012) Erhard Bieberich   NEUROCHEMICAL RESEARCH

Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics

(2012) H. Beck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of C6-ceramide-interacting proteins in D6P2T Schwannoma cells

(2012) Venkatesh Kota et al.   PROTEOMICS

Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity

(2011) Ana-Marija Domijan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

ATP: A ubiquitous gliotransmitter integrating neuron–glial networks

(2011) Arthur M. Butt   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

(2010) Norman J. Haughey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane

(2010) Delphine Milhas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Quantifying colocalization by correlation: The Pearson correlation coefficient is superior to the Mander's overlap coefficient

(2010) Jeremy Adler et al.   CYTOMETRY PART A

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

Identification and Characterization of Murine Mitochondria-associated Neutral Sphingomyelinase (MA-nSMase), the Mammalian Sphingomyelin Phosphodiesterase 5

(2010) Bill X. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+Loading Capacity and Promotes Apoptosis

(2010) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

(2010) Qi Hou et al.   JOURNAL OF LIPID RESEARCH

Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

(2010) C. Muscoli et al.   JOURNAL OF NEUROSCIENCE

Fibrillar Amyloid- -Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

(2010) A. Jana et al.   JOURNAL OF NEUROSCIENCE

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

(2010) Bill X. Wu et al.   NEUROMOLECULAR MEDICINE

Is Amyotrophic Lateral Sclerosis a Mitochondrial Channelopathy?

(2010) Virginia Le Verche et al.   NEURON

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

(2009) Amadou K.S. Camara et al.   ANTIOXIDANTS & REDOX SIGNALING

Plasma membrane tubulin

(2009) J. Wolff   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein-lipid interactions: paparazzi hunting for snap-shots

(2009) Per Haberkant et al.   BIOLOGICAL CHEMISTRY

Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130

(2009) Sabrina Rivero et al.   EMBO JOURNAL

Regulation of primary cilia formation by ceramide

(2009) Guanghu Wang et al.   JOURNAL OF LIPID RESEARCH

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Ceramide-enriched membrane domains—Structure and function

(2008) Yang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VDAC regulation: role of cytosolic proteins and mitochondrial lipids

(2008) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

(2008) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-  Involves Protein Kinase C-  in Lung Epithelial Cells

(2008) C. J. Clarke et al.   MOLECULAR PHARMACOLOGY

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

(2008) T. K. Rostovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA