Journal
NEURON
Volume 67, Issue 4, Pages 523-524Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.08.010
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Funding
- NINDS NIH HHS [R01 NS042269-07, R01 NS042269] Funding Source: Medline
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SOD1 is a cause of the fatal, paralytic disorder ALS. Although mechanisms underlying mutant SOD1 neurotoxicity remain uncertain, this protein associates with mitochondria. In this issue of Neuron, Israelson et al. show that mutant SOD1 binds and inhibits the mitochondria! channel VDAC1. This finding sheds light onto possible molecular links between mutant SOD1, mitochondrial dysfunction, and spinal motor neuron degeneration in inherited ALS.
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