Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
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Title
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 28, Pages E5549-E5558
Publisher
Proceedings of the National Academy of Sciences
Online
2017-06-27
DOI
10.1073/pnas.1705134114
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- (2011) Brian M. Barth et al. JOURNAL OF NEUROSCIENCE RESEARCH
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- (2011) María Mittelbrunn et al. Nature Communications
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- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane
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- (2010) Simone Filosto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology
- (2009) Catherine Pavoine et al. CARDIOVASCULAR RESEARCH
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