A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors

(2014) Marta Martínez-Díez et al.   BIOCHEMICAL PHARMACOLOGY

New Interfacial Microtubule Inhibitors of Marine Origin, PM050489/PM060184, with Potent Antitumor Activity and a Distinct Mechanism

(2013) Benet Pera et al.   ACS Chemical Biology

Total Synthesis of the Tubulin Inhibitor WF-1360F Based on Macrocycle Formation through Ring-Closing Alkyne Metathesis

(2013) Christian M. Neuhaus et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds

(2013) María Jesús Martín et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody–drug conjugates

(2013) Rachel S. Zolot et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Structural plasticity of tubulin assembly probed by vinca-domain ligands

(2012) Fanomezana M. Ranaivoson et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

The Promise of Antibody–Drug Conjugates

(2012) Beverly A. Teicher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolution

(2010) Franck J. Fourniol et al.   JOURNAL OF CELL BIOLOGY

Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules

(2010) M. Lopus et al.   MOLECULAR CANCER THERAPEUTICS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Tubulin: A Target for Antineoplastic Drugs into the Cancer Cells but also in the Peripheral Nervous System

(2009) Annalisa Canta et al.   CURRENT MEDICINAL CHEMISTRY

Structural insight into the inhibition of tubulin by vinca domain peptide ligands

(2008) Anthony Cormier et al.   EMBO REPORTS