Shared mechanisms among neurodegenerative diseases: from genetic factors to gene networks

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

(2018) Nicholas J. Kramer et al.   NATURE GENETICS

Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology

(2017) Jose A. Santiago et al.   Frontiers in Aging Neuroscience

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

(2017) Le Shu et al.   PLoS Genetics

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

(2016) Irene López González et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

(2016) Ritchie Ho et al.   NATURE NEUROSCIENCE

Gene expression profiles and protein-protein interaction networks in amyotrophic lateral sclerosis patients with C9orf72 mutation

(2016) Meena Kumari Kotni et al.   Orphanet Journal of Rare Diseases

Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

(2016) J V Sanchez-Mut et al.   Translational Psychiatry

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

(2015) Neelroop N. Parikshak et al.   NATURE REVIEWS GENETICS

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases

(2015) Ping Li et al.   PLoS One

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

(2014) M. Narayanan et al.   Molecular Systems Biology

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

(2014) Matthew D Li et al.   Acta Neuropathologica Communications

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia

(2012) Marka van Blitterswijk et al.   CURRENT OPINION IN NEUROLOGY

Gene expression profiling in human neurodegenerative disease

(2012) Johnathan Cooper-Knock et al.   Nature Reviews Neurology

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors

(2010) Taye H Hamza et al.   JOURNAL OF HUMAN GENETICS

An estimate of amyotrophic lateral sclerosis heritability using twin data

(2010) A. Al-Chalabi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

The "etiome": identification and clustering of human disease etiological factors

(2009) Yueyi I Liu et al.   BMC BIOINFORMATICS

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

(2009) Christiaan GJ Saris et al.   BMC GENOMICS

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY