Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

Expression Profiles of Cytokines in the Brains of Alzheimer's Disease (AD) Patients Compared to the Brains of Non-Demented Patients with and without Increasing AD Pathology

(2018) Kaori Morimoto et al.   JOURNAL OF ALZHEIMERS DISEASE

An Updated Meta-Analysis of the Association between SORL1 Variants and the Risk for Sporadic Alzheimer's Disease

(2018) Chunhui Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

(2017) Claudia Schwab et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Serum sTNFR1 Level Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease

(2017) Breno Satler Diniz et al.   JOURNAL OF ALZHEIMERS DISEASE

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

(2015) Leon M. Tai et al.   JOURNAL OF NEUROCHEMISTRY

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

(2015) Erdinç Dursun et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Go with your gut: microbiota meet microglia

(2015) Kira Irving Mosher et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Periodontal disease associates with higher brain amyloid load in normal elderly

(2015) Angela R. Kamer et al.   NEUROBIOLOGY OF AGING

TREM2 variants and risk of Alzheimer’s disease: a meta-analysis

(2015) Yanjun Lu et al.   NEUROLOGICAL SCIENCES

Complex Deregulation and Expression of Cytokines and Mediators of the Immune Response in Parkinson's Disease Brain is Region Dependent

(2014) Paula Garcia-Esparcia et al.   BRAIN PATHOLOGY

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals

(2014) Lisa L. Barnes et al.   JOURNAL OF INFECTIOUS DISEASES

Immune responses in rapidly progressive dementia: a comparative study of neuroinflammatory markers in Creutzfeldt-Jakob disease, Alzheimer's disease and multiple sclerosis

(2014) Katharina Stoeck et al.   Journal of Neuroinflammation

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

CR1 in Alzheimer's Disease

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease

(2014) Evan Dorey et al.   Neuroscience Bulletin

Subtype and Regional-Specific Neuroinflammation in Sporadic Creutzfeldt–Jakob Disease

(2014) Franc Llorens et al.   Frontiers in Aging Neuroscience

Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

(2014) Adam C. Naj et al.   JAMA Neurology

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region

(2013) William T. Wissemann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

CD33 in Alzheimer's Disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

(2013) Agustín Ruiz et al.   NEUROBIOLOGY OF AGING

Herpes virus in Alzheimer's disease: relation to progression of the disease

(2013) Ilaria Carbone et al.   NEUROBIOLOGY OF AGING

Effect of Proinflammatory Gene Polymorphisms on the Risk of Alzheimer's Disease

(2013) Andrea Flex et al.   Neurodegenerative Diseases

Patterns of microglial cell activation in frontotemporal lobar degeneration

(2013) Suzannah B. Lant et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population

(2013) Kun Nie et al.   NEUROSCIENCE LETTERS

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

(2013) Akinori Miyashita et al.   PLoS One

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD

(2013) Qi Shi et al.   Virology Journal

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease

(2012) Pamela Sparks Stein et al.   Alzheimers & Dementia

Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients

(2012) Dariusz Koziorowski et al.   CYTOKINE

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

(2012) Peter Holmans et al.   HUMAN MOLECULAR GENETICS

Infections as a risk factor for Parkinson's disease: a case–control study

(2012) Hristina Vlajinac et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness

(2012) Rui Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Reduced T helper and B lymphocytes in Parkinson's disease

(2012) Claire H. Stevens et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammatory phenotype in early Alzheimer's disease

(2012) Tiffany L. Sudduth et al.   NEUROBIOLOGY OF AGING

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes

(2012) Philipp Mahlknecht et al.   Proteome Science

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

(2011) Christiane Reitz   ARCHIVES OF NEUROLOGY

Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly

(2011) F. Sardi et al.   AUTOIMMUNITY REVIEWS

Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han Chinese population

(2011) Xiang Xu et al.   BRAIN RESEARCH

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome

(2011) W. J. Lukiw et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation

(2011) Arianna Bellucci et al.   Neurodegenerative Diseases

Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden

(2011) Xinjun Li et al.   Neurodegenerative Diseases

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

Cytokine expression and microglial activation in progressive supranuclear palsy

(2011) Rafael Fernández-Botrán et al.   PARKINSONISM & RELATED DISORDERS

Neurodegeneration and Inflammation in Parkinson's disease

(2011) Sudarshan Phani et al.   PARKINSONISM & RELATED DISORDERS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region

(2011) Erin M. Hill-Burns et al.   PLoS One

History of Innate Immunity in Neurodegenerative Disorders

(2011) Patrick L. McGeer et al.   Frontiers in Pharmacology

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Inflammation and Alzheimer’s disease

(2010) Young-Jung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of the human leucocyte antigen region with susceptibility to Parkinson's disease

(2010) M. Saiki et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Imaging Approaches to Parkinson Disease

(2010) D. J. Brooks   JOURNAL OF NUCLEAR MEDICINE

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

The probable relation between Toxoplasma gondii and Parkinson's disease

(2010) Ozlem Miman et al.   NEUROSCIENCE LETTERS

The Role of Inflammatory Cytokines in Cognition and Other Non-Motor Symptoms of Parkinson's Disease

(2010) M. Menza et al.   PSYCHOSOMATICS

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

(2009) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease?

(2009) Kie Honjo et al.   Alzheimers & Dementia

Peripheral Cytokines and Chemokines in Alzheimer’s Disease

(2009) Kang Soo Lee et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

(2009) Orestes Vicente Forlenza et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

NSAID Use and the Risk of Parkinsonʼs Disease

(2009) Ali Samii et al.   DRUGS & AGING

Biomarkers of inflammation and amyloid-β phagocytosis in patients at risk of Alzheimer disease

(2009) Milan Fiala et al.   EXPERIMENTAL GERONTOLOGY

Increased serum levels of soluble tumor necrosis factor-α receptor-1 in patients with Parkinson's disease

(2009) Paula Scalzo et al.   JOURNAL OF NEUROIMMUNOLOGY

Macrophage-Mediated Degradation of  -Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

(2009) L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex

(2009) Elaine Leung et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Autoimmune disease and risk for Parkinson disease: A population-based case-control study

(2009) K. Rugbjerg et al.   NEUROLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Neuroinflammation in the living brain of Parkinson's disease

(2009) Yasuomi Ouchi et al.   PARKINSONISM & RELATED DISORDERS

The influence of microglia on the pathogenesis of Parkinson's disease

(2009) Caitríona M. Long-Smith et al.   PROGRESS IN NEUROBIOLOGY

Viral parkinsonism

(2008) Haeman Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Peripheral cytokines profile in Parkinson’s disease

(2008) M. Reale et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation-related genes and the risk of Parkinson’s disease: a multilocus approach

(2008) J. Infante et al.   EUROPEAN JOURNAL OF NEUROLOGY

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory markers in AD and MCI patients with different biomarker profiles

(2008) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Interleukin-10 (IL10) and tumor necrosis factor α (TNF) gene polymorphisms in Parkinson's disease patients

(2008) M. Bialecka et al.   PARKINSONISM & RELATED DISORDERS

Serum inflammatory biomarkers in Parkinson's disease

(2008) M. Dufek et al.   PARKINSONISM & RELATED DISORDERS

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY

SORL1 variants and risk of late-onset Alzheimer’s disease

(2007) Yonghong Li et al.   NEUROBIOLOGY OF DISEASE