The rhomboid protease family: a decade of progress on function and mechanism

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Structural and mechanistic basis of Parl activity and regulation

(2011) D V Jeyaraju et al.   CELL DEATH AND DIFFERENTIATION

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

(2011) Guang Shi et al.   HUMAN MOLECULAR GENETICS

Invasion and intracellular survival by protozoan parasites

(2011) L. David Sibley   IMMUNOLOGICAL REVIEWS

Insights into Substrate Gating in H. influenzae Rhomboid

(2011) Cory L. Brooks et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Rhomboid Protease in a Lipid Environment

(2011) Kutti R. Vinothkumar   JOURNAL OF MOLECULAR BIOLOGY

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

(2010) Olivier A. Pierrat et al.   ACS Chemical Biology

Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis

(2010) Sinisa Urban   BIOCHEMICAL JOURNAL

Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Rhomboid Protease PARL

(2010) Anthony E. Civitarese et al.   Cell Metabolism

The structural basis for catalysis and substrate specificity of a rhomboid protease

(2010) Kutti R Vinothkumar et al.   EMBO JOURNAL

Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis

(2010) Leigh A. Baxt et al.   EUKARYOTIC CELL

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode

(2010) J. M. Santos et al.   SCIENCE

Rhomboid 4 (ROM4) Affects the Processing of Surface Adhesins and Facilitates Host Cell Invasion by Toxoplasma gondii

(2010) Jeffrey S. Buguliskis et al.   PLoS Pathogens

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins

(2009) A. Oberai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhomboid Protease Dynamics and Lipid Interactions

(2009) Ana-Nicoleta Bondar et al.   STRUCTURE

Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis

(2009) Prakash Srinivasan et al.   PLoS Pathogens

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells

(2008) Sinisa Urban et al.   BIOLOGICAL CHEMISTRY

A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis

(2008) Y. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

(2008) A. J. Whitworth et al.   Disease Models & Mechanisms

Microneme Rhomboid Protease TgROM1 Is Required for Efficient Intracellular Growth ofToxoplasma gondii

(2008) Fabien Brossier et al.   EUKARYOTIC CELL

An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion

(2008) L. A. Baxt et al.   GENES & DEVELOPMENT

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

(2008) Jyh-Rong Chao et al.   NATURE

Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration

(2008) Özlem Doğan Ekici et al.   PROTEIN SCIENCE

Rhomboids: 7 years of a new protease family

(2008) Matthew Freeman   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of Trafficking Determinants for Polytopic Rhomboid Proteases in Toxoplasma gondii

(2008) Lilach Sheiner et al.   TRAFFIC