The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch

(2017) Christian Kranjec et al.   JOURNAL OF PATHOLOGY

Notch1 Overexpression Correlates to Improved Survival in Cancer of the Oropharynx

(2017) Azeem S. Kaka et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Notch4+ cancer stem-like cells promote the metastatic and invasive ability of melanoma

(2016) Xian Lin et al.   CANCER SCIENCE

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

(2016) Genta Sawada et al.   GASTROENTEROLOGY

Association of Notch4 with metastasis in human oral squamous cell carcinoma

(2016) Harishankar MK et al.   LIFE SCIENCES

Notch 2 signaling contributes to cell growth, anti-apoptosis and metastasis in laryngeal squamous cell carcinoma

(2016) You Zou et al.   Molecular Medicine Reports

Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells

(2016) WEN-RUI WU et al.   ONCOLOGY REPORTS

Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer

(2016) Pawan Upadhyay et al.   Oncotarget

HES1 mRNA expression is associated with survival in sinonasal squamous cell carcinoma

(2016) Markus Wirth et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma

(2016) Kou Kayamori et al.   PLoS One

Notch2 as a promising prognostic biomarker for oesophageal squamous cell carcinoma

(2016) Cong Wang et al.   Scientific Reports

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

(2016) Zhi-Li Zhao et al.   Scientific Reports

Delta-like ligand 4-targeted nanomedicine for antiangiogenic cancer therapy

(2015) Ya-Rong Liu et al.   BIOMATERIALS

Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features

(2015) E. M. Rettig et al.   Cancer Prevention Research

NOTCH Mutations: Multiple Faces in Human Malignancies

(2015) L. Mao   Cancer Prevention Research

Differential effects of targeting Notch receptors in a mouse model of liver cancer

(2015) Erik G. Huntzicker et al.   HEPATOLOGY

Identification of genomic mutations associated with clinical outcomes of induction chemotherapy in patients with head and neck squamous cell carcinoma

(2015) Chan-Young Ock et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

(2015) Bruno M. Simões et al.   Cell Reports

Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance

(2015) Andre Luiz Vettore et al.   Genome Medicine

Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis

(2015) Xun Yuan et al.   Scientific Reports

CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma

(2014) T Fukusumi et al.   BRITISH JOURNAL OF CANCER

Notch1 Mutations Are Drivers of Oral Tumorigenesis

(2014) E. Izumchenko et al.   Cancer Prevention Research

The Cancer Genome Atlas findings in head and neck cancer

(2014) Gilberto de Castro et al.   CURRENT OPINION IN ONCOLOGY

A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma

(2014) Ana De Jesus-Acosta et al.   INVESTIGATIONAL NEW DRUGS

Expression pattern of Notch intracellular domain (NICD) and Hes-1 in preneoplastic and neoplastic human oral squamous epithelium: their correlation with c-Myc, clinicopathological factors and prognosis in Oral cancer

(2014) Ravindran Gokulan et al.   MEDICAL ONCOLOGY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2014) Daria A. Gaykalova et al.   PLoS One

Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix

(2014) Richa Tripathi et al.   PLoS One

Activation of the NOTCH Pathway in Head and Neck Cancer

(2013) W. Sun et al.   CANCER RESEARCH

Common and Complex Notch1 Mutations in Chinese Oral Squamous Cell Carcinoma

(2013) Xiaomeng Song et al.   CLINICAL CANCER RESEARCH

The pathological significance of Notch1 in oral squamous cell carcinoma

(2013) Ryoji Yoshida et al.   LABORATORY INVESTIGATION

NOTCH3 Is a Prognostic Factor That Promotes Glioma Cell Proliferation, Migration and Invasion via Activation of CCND1 and EGFR

(2013) Mohammad A. Y. Alqudah et al.   PLoS One

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

(2013) C. R. Pickering et al.   Cancer Discovery

TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells

(2012) Sung Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A phase II study of RO4929097 in metastatic colorectal cancer

(2012) Jonathan R. Strosberg et al.   EUROPEAN JOURNAL OF CANCER

Suppression of tongue squamous cell carcinoma growth by inhibition of Jagged1in vitroandin vivo

(2012) Tong-han Zhang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Elevated DLL4 expression is correlated with VEGF and predicts poor prognosis of nasopharyngeal carcinoma

(2012) Jia-Xing Zhang et al.   MEDICAL ONCOLOGY

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Promoter methylation and loss ofp16INK4agene expression in head and neck cancer

(2011) Semra Demokan et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma

(2011) Cheuk-Him Man et al.   JOURNAL OF PATHOLOGY

Delta-Like Ligand 4–Notch Blockade and Tumor Radiation Response

(2011) Stanley K. Liu et al.   JNCI-Journal of the National Cancer Institute

Cancer: The flipside of Notch

(2011) Demetrios Kalaitzidis et al.   NATURE

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Association of High Levels of Jagged-1 and Notch-1 Expression with Poor Prognosis in Head and Neck Cancer

(2010) Jen-Tsun Lin et al.   ANNALS OF SURGICAL ONCOLOGY

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Notch signaling in human tongue carcinoma

(2010) Tong-Han Zhang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer

(2009) Yu-Chih Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins

(2009) M. L. Poeta et al.   CLINICAL CANCER RESEARCH

Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer

(2009) Young-Hoon Joo et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Signaling: A Potential Therapeutic Target in Prostate Cancer

(2008) M. Villaronga et al.   CURRENT CANCER DRUG TARGETS

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Head and neck cancer

(2008) Athanassios Argiris et al.   LANCET